ATP Synthase Mitochondrial

ATP Synthase Mitochondrial

ATP Synthase Mitochondrial

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  • View Data Sheet

    Description:

    ATP Synthase Mitochondrial Fo Complex Subunit D Human Recombinant

    ATP Synthase H+ Transporting, Mitochondrial Fo Complex Subunit D, ATP Synthase D Chain Mitochondrial, ATP Synthase H+ Transporting Mitochondrial F1F0 Subunit D, ATPase Subunit D, My032 Protein, ATPQ.

    Product # :

    PRO-1631

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    • description
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    Description

    ATP5H Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 184 amino acids (1-161) and having a molecular mass of 20.9kDa.ATP5H is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The ATP5H solution contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

    Purity

    Greater than 85% as determined by SDS-PAGE.

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    • Introduction

      ATP5H is a member of the ATPase d subunit family and encodes the d subunit of the F0 complex. Electron transport complexes of the respiratory chain create a proton gradient across the membrane which induces ATP5H to transform ADP to ATP. Two alternatively spliced isoforms of ATP5H, encoded by a gene that maps to human chromosome 17q25.1, are known. ATP5H is restricted to mitochondrial inner membrane.

    • Synonyms

      ATP Synthase H+ Transporting, Mitochondrial Fo Complex Subunit D, ATP Synthase D Chain Mitochondrial, ATP Synthase H+ Transporting Mitochondrial F1F0 Subunit D, ATPase Subunit D, My032 Protein, ATPQ.

    • Physical Appearance

      Sterile filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMAGRKLA LKTIDWVAFA EIIPQNQKAI ASSLKSWNET LTSRLAALPE NPPAIDWAYY KANVAKAGLV DDFEKKFNAL KVPVPEDKYT AQVDAEEKED VKSCAEWVSL SKARIVEYEK EMEKMKNLIP FDQMTIEDLN EAFPETKLDK KKYPYWPHQP IENL

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Atp5H Human
  • View Data Sheet

    Description:

    Synthase Transporting Mitochondrial Fo Complex B1 Human Recombinant

    ATP Synthase Proton-Transporting Mitochondrial F(0) Complex Subunit B1, ATP Synthase H+ Transporting, Mitochondrial Fo Complex Subunit B Isoform 1, ATPase Subunit B, ATP Synthase B Chain Mitochondrial, Cell Proliferation-Inducing Protein 47, PIG47.

    Product # :

    PRO-1839

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    Description

    ATP5F1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 197 amino acids (83-256) and having a molecular mass of 22.6 kDa. ATP5F1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The ATP5F1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

    Purity

    Greater than 80% as determined by SDS-PAGE.

    More Info

    • Introduction

      ATP5F1 is a mitochondrial ATP synthase subunit catalyzes ATP synthesis, using an electrochemical gradient of protons all through the inner membrane for the duration of the oxidative phosphorylation. ATP synthase is comprised of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, including the proton channel. The catalytic segment of mitochondrial ATP synthase contains 9 subunits: 3 alpha, 3 beta, and one unit of gamma, delta, and epsilon. The proton route is known to have 9 subunits (a, b, c, d, e, f, g, F6 and 8).

    • Synonyms

      ATP Synthase Proton-Transporting Mitochondrial F(0) Complex Subunit B1, ATP Synthase H+ Transporting, Mitochondrial Fo Complex Subunit B Isoform 1, ATPase Subunit B, ATP Synthase B Chain Mitochondrial, Cell Proliferation-Inducing Protein 47, PIG47.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSLILYALS KEIYVISAET FTALSVLGVM VYGIKKYGPF VADFADKLNE QKLAQLEEAK QASIQHIQNA IDTEKSQQAL VQKRHYLFDV QRNNIAMALE VTYRERLYRV YKEVKNRLDY HISVQNMMRR KEQEHMINWV EKHVVQSIST QQEKETIAKC IADLKLLAKK AQAQPVM

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Atp5F1 Human
  • View Data Sheet

    Description:

    ATP Synthase Gamma Chain, Mitochondria Human Recombinant

    ESE3, ESE3B, ESEJ, F-ATPase gamma subunit, ATP5C1, ATP5CL1, ATP5C, ATP synthase subunit gamma, mitochondrial.

    Product # :

    PRO-1494

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    Description

    ATP5C1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 296 amino acids (26-298 a.a.) and having a molecular mass of 32.6kDa.ATP5C1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    ATP5C1 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.4M Urea and 10% glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      ATP synthase subunit gamma, mitochondrial isoform L (liver) (ATP5C1) is a member of the ATPase gamma chain family. ATP5C1 catalyzes ATP synthesis by using an electrochemical gradient of protons across the inner membrane throughout oxidative phosphorylation. The catalytic portion of mitochondrial ATP synthase is comprised of 5 different subunits (alpha, beta, gamma, delta, and epsilon) gathered with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3.

    • Synonyms

      ESE3, ESE3B, ESEJ, F-ATPase gamma subunit, ATP5C1, ATP5CL1, ATP5C, ATP synthase subunit gamma, mitochondrial.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSATLKDIT RRLKSIKNIQ KITKSMKMVA AAKYARAERE LKPARIYGLG SLALYEKADI KGPEDKKKHL LIGVSSDRGL CGAIHSSIAK QMKSEVATLT AAGKEVMLVG IGDKIRGILY RTHSDQFLVA FKEVGRKPPT FGDASVIALE LLNSGYEFDE GSIIFNKFRS VISYKTEEKP IFSLNTVASA DSMSIYDDID ADVLQNYQEY NLANIIYYSL KESTTSEQSA RMTAMDNASK NASEMIDKLT LTFNRTRQAV ITKELIEIIS GAAALD.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Atp5C1 Human


About ATP Synthase Mitochondrial:

The ATP synthase is a form of enzyme which helps to form the energy storage molecule known as adenosine triphosphate (ATP). It does so primarily by making use of adenosine diphosphate (ADP), along with some inorganic phosphate (P). The reaction that is produced overall by this process can be described as: ADP + Pi + 2H+out ⇌ ATP + H2O + 2H+in

ATP Synthase Mitochondrial Structure & Function
It is located within the thylakoid membrane and the inner mitochondrial membrane, and it consists of two regions FO and F1. The former causes a rotation of the latter, being made of c-ring and subunits a, two b, and F6. The F1 region is hydrophilic, and hydrolyzes ATP. The other is a water insoluble protein with eight subunits and a transmembrane ring, which causes neighbouring subunits to rotate.

ATP Synthase Mitochondrial Physiological Role
Like other enzymes, the action that this produce is also reversible. With large enough quantities of ATP, a transmembrane proton gradient is produced, which is in turn to be used by fermenting bacteria without an electron transport chain, and this drives flagella along with the transport of nutrients into a cell.
In the respiring bacteria in physiological conditions, ATP synthase generally runs in the opposite direction, thus creating ATP using the proton motive force created by the electron transport chain as its energy. This overall process is generally referred to as oxidative phosphorylation.

ATP Synthase Mitochondrial Inhibitors
There have been a variety of inhibitors discovered for the ATP, some of which may prove to be of some therapeutic usage, such as peptide inhibitors, polyphenolic phytochemicals, polyketides, and organotin compounds.