Anterior Gradient Protein

Anterior Gradient Protein

Anterior Gradient Protein

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  • View Data Sheet

    Description:

    Anterior Gradient Protein 3 Homolog Human Recombinant

    Anterior gradient protein 3 homolog, AG-3, AG3, hAG-3, Breast cancer membrane protein 11, AGR3, BCMP11, UNQ642/PRO1272, HAG3, PDIA18.

    Product # :

    PRO-242

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    Description

    AGR3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids (22-166 a.a) and having a molecular mass of 19.5kDa.AGR3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    AGR3 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

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    • Introduction

      Anterior gradient protein 3 homolog precursor (AGR3) is a secreted cytoplasmic protein that is involved in metastasis induction and p53 tumor suppressor inhibition. AGR3 may function as molecular marker and potential therapeutic target for hormone-responsive breast tumors.

    • Synonyms

      Anterior gradient protein 3 homolog, AG-3, AG3, hAG-3, Breast cancer membrane protein 11, AGR3, BCMP11, UNQ642/PRO1272, HAG3, PDIA18.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMIAIKKE KRPPQTLSRG WGDDITWVQT YEEGLFYAQK SKKPLMVIHH LEDCQYSQAL KKVFAQNEEI QEMAQNKFIM LNLMHETTDK NLSPDGQYVP RIMFVDPSLT VRADIAGRYS NRLYTYEPRD LPLLIENMKK ALRLIQSEL.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Agr3 Human
  • View Data Sheet

    Description:

    Anterior Gradient Protein 2 Homolog Mouse Recombinant

    Agr2h, Gob-4, HAG-2, mAG-2, XAG-2, AG-2, Protein Gob-4, Secreted cement gland protein XAG-2 homolog.

    Product # :

    PRO-2395

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    Description

    AGR2 Mouse Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 180 amino acids (21-175) and having a molecular mass of 20.5kDa.AGR2 is fused to a 25 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The AGR2 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 1mM EDTA and 20% glycerol.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      AGR2 (Anterior gradient 2 homolog) is the human orthologue of the secreted Xenopus laevis Anterior Gradient protein (XAG-2). This is a small, possibly secreted molecule of yet weakly defined functions that is widely expressed in human tissues. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of EGF receptor.

    • Synonyms

      Agr2h, Gob-4, HAG-2, mAG-2, XAG-2, AG-2, Protein Gob-4, Secreted cement gland protein XAG-2 homolog.

    • Physical Appearance

      Sterile Filtered clear colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMKDTTV KSGAKKDPKD SRPKLPQTLS RGWGDQLIWT QTYEEALYRS KTSNRPLMVI HHLDECPHSQ ALKKVFAEHK EIQKLAEQFV LLNLVYETTD KHLSPDGQYV PRIVFVDPSL TVRADITGRY SNRLYAYEPS DTALLYDNMK KALKLLKTEL.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Agr2 Mouse
  • View Data Sheet

    Description:

    Anterior Gradient Protein 2 Homolog Human Recombinant

    Anterior gradient protein 2 homolog, Secreted cement gland protein XAG-2 homolog, AG-2, hAG-2, HPC8, AGR2, AG2, GOB-4, HAG-2, XAG-2.

    Product # :

    PRO-580

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    • description
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    • More Info

    Description

    AGR2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 191 amino acids (21-175 a.a.) and having a molecular mass of 21.9 kDa. AGR2 protein is fused to a 36 amino acid His-Tag at N-terminus and purified by standard chromatography.

    Source

    Escherichia Coli.

    Formulation

    The protein contains 20mM Tris-HCl pH 8.0, 1mM DTT, 1mM EDTA and 10% Glycerol.

    Purity

    Greater than 95.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      AGR2 (Anterior gradient 2 homolog) is the human orthologue of the secreted Xenopus laevis Anterior Gradient protein (XAG-2). This is a small, possibly secreted molecule of yet weakly defined functions that is widely expressed in human tissues. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of EGF receptor.

    • Synonyms

      Anterior gradient protein 2 homolog, Secreted cement gland protein XAG-2 homolog, AG-2, hAG-2, HPC8, AGR2, AG2, GOB-4, HAG-2, XAG-2.

    • Physical Appearance

      Sterile filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMRDT TVKPGAKKDT KDSRPKLPQT LSRGWGDQLI WTQTYEEALY KSKTSNKPLM IIHHLDECPH SQALKKVFAE NKEIQKLAEQ FVLLNLVYET TDKHLSPDGQ YVPRIMFVDP SLTVRADITG RYSNRLYAYE PADTALLLDN MKKALKLLKT EL.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Agr2 Human

About AGR / Anterior Gradient Protein:

Anterior gradient protein 2 homolog (AGR-2), is a protein found in the human body and in encoded by the AGR2 gene. This protein can also be known as secreted cement gland protein XAG-2 homolog. Anterior gradient homolog 2 was first discovered in Xenopus laevis which is known as the African clawed frog. Inside this animal, AGR plays an important role in cement gland differentiation.

Anterior Gradient Protein Function
In humans, cancer cells with a high level of AGR2 correlates with downregulation or the p53 response. The P53 response mediates the cellular response to DNA damage and triggers DNA repair and this is something that is crucial for the body. It also correlated with the downregulation of cell migration and cell transformation. It has also been observed in several cases that the AGR2 protein can repress cell growth as well as proliferation. This is something that could in theory reduce the risk of certain cancers.

AGR Structure
AGR2 is a protein disulfide isomerase and contains a single CXXS domain within the protein for both oxidation and reduction reactions. AGR2 forms intestinal mucin as well as other mixed disulphides in substrates. The interaction of AGR2 with Mucin 2 forms a heterodisulfide bond in MUC2.

Anterior Gradient Protein Interactions
It is important to note that AGR2 plays an important role in protein folding, and it contains a KTEL C-terminal motif that is similar to both KDEL and KVEL endoplasmic reticulum retention sequences.
AGR2 protein interacts with C4.4A and DAG-1 proteins. These proteins are associated with metastasis which is the spread of cancer cells from their origin in the body to other parts of the body. AGR2 has also been known to bind to reptin which is a tumour repressor.