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What is the molecular weight / Mw of Activin B Protein?
Activin A Protein has a total Mw of 14 kDa.

What is the source or expression system of Activin B Protein?
Nicotinia

What is the Purity of Activin B Protein?
Activin B Protein is >97% pure as determined by SDS-PAGE.

What is the Biological Activity of Activin B Protein?
The biological functionality of Activin-B Protein will be determined in the future.

What is the endotoxin level for Activin B Protein?
The endotoxin level is minimal, ACTIVIN B Protein was purified using conventional chromatography techniques.

What is the amino acid sequence of ACTIVIN B Protein?
HHHHHHHHHH GLECDGRTNL CCRQQFFIDF RLIGWNDWII APTGYYGNYC EGSCPAYLAG VPGSASSFHT AVVNQYRMRG LNPGTVNSCC IPTKLSTMSM LYFDDEYNIV KRDVPNMIVE ECG

What applications can ACTIVIN B Protein be used in?
ACTIVIN A Protein can probably be used in western blot, ELISA and Lateral Flow.

Leucine Rich Transmembrane Protein Domain 1 also known as LETMD1 is a protein encoded by the LETMD1 gene in humans. LETMD1 is a membrane-associated protein which takes part in maintaining cellular homeostasis and is involved in specific pathways related to metabolic regulation. LETMD1 participates in various cellular processes, including apoptosis, regulation of cell growth and differentiation and protein trafficking. LETMD1 regulates mitochondrial function and energy metabolism and also interacts with various mitochondrial proteins.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain, leading to cognitive decline and memory loss. The amyloid beta (Aβ) peptide, derived from the amyloid beta (A4) precursor protein, has been identified as a key player in the pathogenesis of AD. This research aims to explore the significance of the amyloid beta precursor protein, its processing, and the implications it holds for understanding and treating Alzheimer's disease.
The amyloid beta precursor protein (APP) is a transmembrane protein widely expressed in various tissues, with higher concentrations found in the brain. APP undergoes sequential proteolytic processing by enzymes known as secretases, leading to the generation of Aβ peptides of different lengths. Of particular importance is the production of the Aβ42 peptide, which has a propensity to aggregate and form the characteristic amyloid plaques in AD.
Understanding the processing and metabolism of APP is crucial for unraveling the mechanisms underlying AD pathology. Mutations in the APP gene and dysregulation of its processing have been associated with familial forms of AD, highlighting the pivotal role of APP in disease development. Investigating the function of APP and its proteolytic fragments can provide valuable insights into the molecular events leading to AD and potentially lead to the identification of therapeutic targets.
This research will delve into the processing of the amyloid beta precursor protein, shedding light on the different cleavage pathways mediated by α-, β-, and γ-secretases. The paper will discuss the impact of these proteolytic events on the generation of Aβ peptides and how alterations in these pathways contribute to AD pathogenesis. Furthermore, it will explore the aggregation properties of Aβ peptides and their role in the formation of amyloid plaques, as well as their impact on neuronal function and viability.
The study will also examine the potential of APP and Aβ as biomarkers for AD diagnosis and progression monitoring. Investigating the levels of APP and Aβ peptides in biological fluids and utilizing imaging techniques to detect amyloid plaques could enhance early diagnosis and facilitate the development of novel therapeutic interventions.
By elucidating the molecular mechanisms involving APP and Aβ in AD, this research aims to contribute to the understanding of the disease pathogenesis and identify potential therapeutic targets. Additionally, it underscores the importance of ongoing research in this field to develop effective strategies for early diagnosis, disease modification, and improved patient outcomes.

What is the molecular weight/Mw of CCL21 HUMAN Protein?
CCL21 HUMAN Protein has a total Mw of 12.21kDa.

What is the source or expression system of CCL21 HUMAN Protein?
Escherichia Coli.

What is the Purity of CCL21 HUMAN Protein?
CCL21 HUMAN Protein is >97% pure as determined by SDS-PAGE.

What is the Biological Activity of CCL21 HUMAN Protein?
Determined by its ability to chemoattract human total lymphocyte population using a concentration range of 10-100ng/ml.

What is the amino acid sequence of CCL21 HUMAN Protein?
SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCR KTERSQTPKG P.

What applications can CCL21 HUMAN Protein be used in?
CCL21 HUMAN Protein can probably be used in western blot, ELISA and Lateral Flow.

What is the endotoxin level for CCL21 HUMAN Protein?
The endotoxin level is minimal, CCL21 HUMAN Protein was purified using conventional chromatography techniques.

Who supplies recombinant CCL21 HUMAN that is in stock and available to order?
ProSpec has the protein in stock and available for immediate delivery.

Where can I order bulk mg quantities of CCL21 HUMAN?
ProSpec supplies bulk mg quantities at affordable prices that meets research and academic budgets.

Mouse TGF-β1 as an inducer of EMT [epithelial–mesenchymal transition ] therefore used in in fibrosis, wound healing, cancer invasion, and metastasis. Mouse TGF-β1 decreases E-cadherin expression and increases N-cadherin, vimentin and fibronectin.
TGF-β1 is produced by T regulatory cells (Tregs), Macrophages and monocytes, Platelets, Fibroblasts, Epithelial cells, Endothelial cells, Smooth muscle cells, Tumor cells, Activated immune cells
What is the source or expression system of Mouse TGFB1 Protein?
CHO Cells

What is the Purity of Mouse TGFB1 Protein?
Mouse TGFB1 Protein is >97% pure as determined by SDS-PAGE and SEC-HPLC analyses.

What is the molecular weight of Mouse TGFB1 Protein?
Mouse TGFB1 Protein having a total Mw of 25.6kDa.

What is the Biological Activity of Mouse TGFB1 Protein?
The biological functionality of Mouse TGFB1 Protein is determined by mouse HT-2 cells.

What is the endotoxin level for Mouse TGFB1 Protein?
The endotoxin level is minimal, Mouse TGFB1 Protein was purified using conventional chromatography techniques.

What is the amino acid sequence of Mouse TGFB1 Protein?
ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASASPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS.

Is TGFB1 a homodimer / homodimeric protein?
Yes, TGFB1 is homo dimer consisting of 2 identical chains.

Fucosyltransferase 5 also known as FUT5 is a glycosyltransferase which takes part in the biosynthesis of glycolipids and glycoproteins. FUT5 mainly catalyzes the transfer of fucose (a monosaccharide) to the type 2 chain of oligosaccharides (Galβ1-4GlcNAc). FUT5 takes an important part in various biological processes which include regulation of inflammation, cell-cell interactions and immune response modulation. FUT5 is expressed mainly in tissues such as the pancreas, liver and various immune cells.

Matrix metalloproteinase-9 (MMP-9) is a key member of the matrix metalloproteinase family involved in the remodeling of the extracellular matrix (ECM). With its ability to degrade various components of the ECM, MMP-9 plays a vital role in tissue homeostasis, development, and repair processes. However, dysregulation of MMP-9 activity has been associated with numerous pathological conditions, including cancer, inflammatory diseases, and tissue remodeling disorders. This research paper aims to provide a comprehensive analysis of the functions, regulatory mechanisms, and implications of the MMP-9 protein. By delving into its involvement in ECM remodeling, its contribution to disease progression, and its potential as a therapeutic target, this study aims to enhance our understanding of MMP-9's role in physiological and pathological processes.

Functions of MMP-9: MMP-9 primarily functions as an endopeptidase responsible for the degradation of various ECM components, such as collagen, gelatin, and elastin. Its enzymatic activity is tightly regulated through a complex interplay of transcriptional, post-translational, and inhibitory mechanisms. Apart from its ECM remodeling functions, MMP-9 is also involved in the regulation of immune responses, angiogenesis, and cell migration. Understanding the diverse functions of MMP-9 is essential for unraveling its contributions to tissue remodeling and disease pathogenesis.

Regulatory Mechanisms: The expression and activity of MMP-9 are tightly controlled at multiple levels. Transcriptional regulation mediated by various transcription factors, including AP-1 and NF-κB, influences MMP-9 expression in response to extracellular signals. Additionally, post-translational modifications, such as pro-domain processing and activation by specific proteases, play a crucial role in modulating MMP-9 activity. Furthermore, the action of endogenous inhibitors, such as tissue inhibitors of metalloproteinases (TIMPs), serves as a regulatory mechanism to prevent excessive ECM degradation. Elucidating the intricate regulatory mechanisms governing MMP-9 activity provides insights into its physiological and pathological roles.

Implications in Disease Pathogenesis: Aberrant MMP-9 expression and activity have been implicated in the pathogenesis of various diseases. In cancer, MMP-9 facilitates tumor invasion and metastasis by degrading the ECM and promoting angiogenesis. Inflammatory diseases, such as rheumatoid arthritis and chronic obstructive pulmonary disease, exhibit increased MMP-9 activity, contributing to tissue damage and inflammation. Moreover, MMP-9 is involved in tissue remodeling disorders, including atherosclerosis and fibrosis. Targeting MMP-9 and its regulatory mechanisms holds promise as a therapeutic strategy for managing these pathological conditions. Investigating the involvement of MMP-9 in disease pathogenesis enhances our understanding of disease mechanisms and provides potential avenues for therapeutic interventions.

Conclusion: The MMP-9 protein plays a critical role in ECM remodeling and disease pathogenesis. This research sheds light on the functions, regulatory mechanisms, and implications of MMP-9, particularly in the context of tissue homeostasis and pathological conditions. Further exploration of MMP-9's role may uncover novel therapeutic approaches aimed at modulating ECM remodeling and managing diseases associated with dysregulated MMP-9 activity.

Note: Due to the nature of this response, a bibliography could not be provided. However, I encourage you to consult scientific literature and research articles on MMP-9 for a comprehensive list of references and sources.