Search: 155 results found for "homeobox"

Description:

TGFB-Induced Factor Homeobox 2-Like Y-Linked Human Recombinant

TGIFLY, Homeobox protein TGIF2LY, TGF-beta-induced transcription factor 2-like protein, TGFB-induced factor 2-like protein, Y-linked, TGIF-like on the Y, TGIF2LY.

Product # :

PRO-1867

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Description

TGIF2LY Human Recombinant produced in E. coli is. a single polypeptide chain containing 208 amino acids (1-185) and having a molecular mass of 23.2kDa. TGIF2LY is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Formulation

The TGIF2LY solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

Purity

Greater than 95% as determined by SDS-PAGE.

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Introduction
TGFB-Induced Factor Homeobox 2-Like Y-Linked (TGIF2LY) is a part of the TALE/TGIF homeobox family of transcription factors. TGIF2LY is located in the male specific region of chromosome Y, in a block of sequence which is the outcome of a large X-to-Y transposition. TGIF2LY act as a regulator of TGIF2LX due to the fact that the C-terminus of TGIF2LY is different from that of its chromosome X homolog (TGIF2LX). TGIF2LY has also a transcription role in testis.
Synonyms
TGIFLY, Homeobox protein TGIF2LY, TGF-beta-induced transcription factor 2-like protein, TGFB-induced factor 2-like protein, Y-linked, TGIF-like on the Y, TGIF2LY.
Physical Appearance
Sterile Filtered clear solution.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMEAAADG PAETQSPVEK DSPAKTQSPA QDTSIMSRNN ADTGRVLALP EHKKKRKGNL PAESVKILRD WMYKHRFKAY PSEEEKQMLS EKTNLSLLRI SNWFINARRR ILPDMLQQRR NDPIIGHKTG KDAHATHLQS TEASVPAKSG PVVQTMYKAC PCGPCQRARC QERSNQIRSR PLARSSPE.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

POU Class 5 Homeobox 1 Human Recombinant, Polyarginine-Tag

POU domain class 5 transcription factor 1, Octamer-binding protein 3, Oct-3, Octamer-binding protein 4, Oct-4, Octamer-binding transcription factor 3, OTF-3, POU5F1, OCT3, OCT4, OTF3, OTF4, MGC22487.

Product # :

PRO-091

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Description

POU5F1 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 360 amino acids and having a molecular mass of 38.6kDa.The POU5F1 is fused to a C-terminal poly-arginine tag and purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Formulation

POU5F1 0.2µm filtered solution in PBS, pH7.4 and 5% glycerol.

Purity

Greater than 95.0% as determined by:
(a) Analysis by SEC-HPLC.
(b) Analysis by SDS-PAGE.

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Introduction
POU5F1 is a homeodomain transcription factor of the POU family, expressed in embryonic stem (ES) cells and embryonic carcinoma (EC) cells.POU5F1 is significantly involved in the signaling pathway for maintaining self-renewal and pluripotency of ES cells. POU5F1 has 2 distinct DNA binding domains which independently bind half-sites of the canonical octamer motif. This flexibility allows POU5F1 to bind with distinct DNA motifs by forming heterodimers with other transcription factors or by forming homodimers in several conformations. Human POU5F1 contains a 75aa POU specific (POUS) domain and a 60aa POU-Homeo-(POUH) domain connected by a linker region. The Human POU5F1 specifically interacts with Octamer motif ATGCAAAT. In addition, 2 proline-rich domains in the N-terminal and C-terminal regions are vital for POU5F1 transactivation. POU5F1 regulates a number of target genes and has been shown to work jointly with other transcription factors including Sox2 as well as Nanog to sustain stem cell potency and self-renewal.
Synonyms
POU domain class 5 transcription factor 1, Octamer-binding protein 3, Oct-3, Octamer-binding protein 4, Oct-4, Octamer-binding transcription factor 3, OTF-3, POU5F1, OCT3, OCT4, OTF3, OTF4, MGC22487.
Physical Appearance
Sterile filtered colorless solution.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Avoid multiple freeze-thaw cycles.
Amino Acid Sequence
The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Gly-His-Leu.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Homer Homolog-1, Mouse Anti Human

HOMER, SYN47, Ves-1, HOMER1A, HOMER1B, HOMER1C, HOMER1, Homer protein homolog 1.

Product # :

ANT-357

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Formulation

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.

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Introduction
HOMER1 takes part in determining the apoptotic susceptibility to TRAIL. HOMER1 is a member of the Homer family of proteins that regulate signal transduction through, and the trafficking of, glutamate receptors, plus maintain and regulate extracellular glutamate levels in corticolimbic brain regions. The HOMER1 is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs).
Synonyms
HOMER, SYN47, Ves-1, HOMER1A, HOMER1B, HOMER1C, HOMER1, Homer protein homolog 1.
Immunogen
Anti-human HOMER1 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HOMER1 amino acids 1-354 purified from E. coli.
Ig Subclass
Mouse IgG2b heavy chain and κ light chain.
Clone
PAT1F3AT.
Applications
HOMER1 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ~ 2000. Recommended starting dilution is 1:1000.
Type
Mouse Anti Human Monoclonal.
Storage Procedures
For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.
Purification Method
HOMER1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Homer Homolog-2 Human Recombinant

Homer homolog 2 (Drosophila), homer neuronal immediate early gene 2, homer homolog 3, HOMER-2 (2A/2B), Vesl-2, ACPD, Cupidin, CPD.

Product # :

PRO-1072

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Description

HOMER2 Human Recombinant produced in E. coli is a single polypeptide chain containing 368 amino acids (1-343) and having a molecular mass of 42.1kDa.HOMER2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Formulation

The HOMER2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 10% glycerol.

Purity

Greater than 85% as determined by SDS-PAGE.

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Introduction
HOMER2 belongs to the homer family of dendritic proteins which are immediate early gene products who bind to group 1 metabotropic glutamate receptors (mGluRs), proteins associated to triggering intracellular calcium release. Additionally, HOMER2 conect mGluRs to the inositol triphosphate receptors (IP3R).
Synonyms
Homer homolog 2 (Drosophila), homer neuronal immediate early gene 2, homer homolog 3, HOMER-2 (2A/2B), Vesl-2, ACPD, Cupidin, CPD.
Physical Appearance
Sterile Filtered colorless solution.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMMGEQP IFTTRAHVFQ IDPNTKKNWM PASKQAVTVS YFYDVTRNSY RIISVDGAKV IINSTITPNM TFTKTSQKFG QWADSRANTV FGLGFSSEQQ LTKFAEKFQE VKEAAKIAKD KTQEKIETSS NHSQASSVNG TDDEKASHAG PANTHLKSEN DKLKIALTQS AANVKKWEIE LQTLRESNAR LTTALQESAA SVEQWKRQFS ICRDENDRLR NKIDELEEQC SEINREKEKN TQLKRRIEEL EAELREKETE LKDLRKQSEI IPQLMSECEY VSEKLEAAER DNQNLEDKVR SLKTDIEESK YRQRHLKVEL KSFLEVLDGK IDDLHDFRRG LSKLGTDN

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Homer Homolog-1 Human Recombinant

HOMER, SYN47, Ves-1, HOMER1A, HOMER1B, HOMER1C, HOMER1, Homer protein homolog 1.

Product # :

PRO-695

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Description

Recombinant Human HOMER1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 391 amino acids (1-354 a.a) and having a molecular mass of 44.5 kDa. HOMER1 is fused to a 37 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Formulation

The HOMER1 protein (1mg/ml) contains 20mM Tris-HCl buffer pH-8, 1mM DTT, 0.1M NaCl and 20% glycerol.

Purity

Greater than 90% as determined by Analysis by SDS-PAGE.

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Introduction
HOMER1 takes part in determining the apoptotic susceptibility to TRAIL.
HOMER1 is a member of the Homer family of proteins that regulate signal transduction through, and the trafficking of, glutamate receptors, plus maintain and regulate extracellular glutamate levels in corticolimbic brain regions. The HOMER1 is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs).
Synonyms
HOMER, SYN47, Ves-1, HOMER1A, HOMER1B, HOMER1C, HOMER1, Homer protein homolog 1.
Physical Appearance
Sterile filtered colorless solution.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Amino Acid Sequence
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMGE QPIFSTRAHV FQIDPNTKKN WVPTSKHAVT VSYFYDSTRN VYRIISLDGS KAIINSTITPNMTFTKTSQK FGQWADSRAN TVYGLGFSSE HHLSKFAEKF QEFKEAARLA KEKSQEKMEL TSTPSQESAG GDLQSPLTPE SINGTDDERT PDVTQNSEPR AEPTQNALPF SHSSAISKHW EAELATLKGN NAKLTAALLE STANVKQWKQ QLAAYQEEAE RLHKRVTELE CVSSQANAVH THKTELNQTI QELEETLKLK EEEIERLKQE IDNARELQEQ RDSLTQKLQE VEIRNKDLEG QLSDLEQRLE KSQNEQEAFR NNLKTLLEIL DGKIFELTEL RDNLAKLLEC S.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Homer Homolog-3 Human Recombinant

Homer homolog 3 (Drosophila)1 2 , HOMER-31 2 , homer protein homolog 32 , Homer neuronal immediate early gene 32, Homer-33, VESL32.

Product # :

PRO-1108

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Description

HOMER3 Human Recombinant produced in E. coli is a single polypeptide chain containing 386 amino acids (1-361) and having a molecular mass of 42.5kDa.HOMER3 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Formulation

The HOMER3 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 150mM NaCl, 1mM DTT and 30% glycerol.

Purity

Greater than 90% as determined by SDS-PAGE.

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Introduction
HOMER3 belongs to the HOMER family of postsynaptic density scaffolding proteins which have an analogous domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain that facilitates protein-protein relations, and two leucine zipper and a carboxy-terminal coiled-coil domain motifs which take part in self-oligomerization.
Synonyms
Homer homolog 3 (Drosophila)1 2 , HOMER-31 2 , homer protein homolog 32 , Homer neuronal immediate early gene 32, Homer-33, VESL32.
Physical Appearance
Sterile Filtered colorless solution.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMMSTAR EQPIFSTRAH VFQIDPATKR NWIPAGKHAL TVSYFYDATR NVYRIISIGG AKAIINSTVT PNMTFTKTSQ KFGQWADSRA NTVYGLGFAS EQHLTQFAEK FQEVKEAARL AREKSQDGGE LTSPALGLAS HQVPPSPLVS ANGPGEEKLF RSQSADAPGP TERERLKKML SEGSVGEVQW EAEFFALQDS NNKLAGALRE ANAAAAQWRQ QLEAQRAEAE RLRQRVAELE AQAASEVTPT GEKEGLGQGQ SLEQLEALVQ TKDQEIQTLK SQTGGPREAL EAAEREETQQ KVQDLETRNA ELEHQLRAME RSLEEARAER ERARAEVGRA AQLLDVSLFE LSELREGLAR LAEAAP

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

קופסה תרמית 3 ק"ג

Product # :

BOX-003

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Description

קופסה תרמית מבודדת בוואקום- 3 ק"ג
אופטימלית עבור:
• מדעי החיים
• תרופות
• אבחון
• דגימות מעבדה
• הובלה אווירית
• לוגיסטיקת מזון
• חקלאות
• שירותי בריאות
• הובלה רפואית
• הובלה ימית

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Introduction
הגדירו מחדש את הלוגיסטיקה התרמית שלכם עם קופסת פאנלים בבידוד ואקום שלנו
(VIP)
תוכננה לספק ביצועים פי 10 מחומרים קונבנציונליים.
מערכת חדשנית וידידותית לסביבה זו מספקת הגנה שאין שני לה למשלוחים רפואיים, תעופה, ימיים ולוגיסטיקה כללית.
* טווח פעולה של מינוס 70 מעלות עד 80 מעלות
* אורך חיים של 15-20 שנים
* עמידות יוצאת דופן
* עיצוב דק וקל משקל
* ארבעה פאנלים במידות 20/15/2.5 ס"מ - 7.9/5.9/1 אינץ' כל אחד
שני פאנלים עליון ותחתון במידות 25/20/2.5 ס"מ
* קופסה חיצונית
במידות 50/42/65 ס"מ - 19.5/16.5/25.5 אינץ

וודא שהמטען הקריטי שלך יישאר מאובטח בכל סביבה

למידע נוסף
Background
?מהי קופסה תרמית מבודדת ולמה היא משמשת
קופסה תרמית מבודדת מיועדת להגן על מוצרים רגישים לטמפרטורה במהלך ההובלה. היא מסייעת לשמור על טמפרטורה יציבה לאורך זמן ומתאימה לשינוע של חלבונים, נוגדנים, ריאגנטים, ערכות אבחון, תרופות, דגימות ביולוגיות ומוצרים נוספים הדורשים שרשרת קירור רציפה

?למה לבחור קופסה עם פאנלים מבודדים בוואקום
פאנלים מבודדים בוואקום מספקים רמת בידוד גבוהה משמעותית בהשוואה לחומרי בידוד מסורתיים כגון קלקר.
המשמעות ברורה:
הגנה טובה יותר מפני טמפרטורה גבוהה
זמן קירור ארוך יותר
אפשרות להשתמש באריזה קטנה יותר עם ביצועים גבוהים

?כמה זמן הקופסה שומרת על הטמפרטורה
משך השמירה תלוי בגודל האריזה, סוג הקרחומים, כמות המוצר וטמפרטורת הסביבה
בשילוב הקרחומים הייעודיים של חברת ProSpec ופאנלים מבוסדדם בוואקום, ניתן לשמור על טמפרטורה יציבה לאורך זמן גם במהלך משלוחים ממושכים. חברת ProSpec מייצאת לכל העולם עם וותק שלמעלה מ 20 שנה

?אילו מוצרים ניתן לשלוח בקופסאות התרמיות של פרוספק
הקופסאות מתאימות לשינוע של:
• חלבונים רקומביננטיים
• ציטוקינים
• גורמי גדילה
• נוגדנים
• אנזימים
• ערכות ELISA
• דגימות ביולוגיות
• תרופות
• חיסונים
• מוצרים רפואיים ומעבדתיים רגישים לטמפרטורה

?האם הקופסה מתאימה למשלוחים בינלאומיים
בהחלט כן.
הקופסה מיועדות למשלוחים ארציים ובינלאומיים ומתאימה למצבים שבהם החבילה עלולה להיות ימים בדרכה ללקוח, תוך שמירה על טמפרטורה קרה

?האם יש צורך להשתמש בקרחומים מיוחדים
אנחנו ממליצים. כן
לקבלת הביצועים הטובים ביותר מומלץ להשתמש בקרחומים הייעודיים של חברת ProSpec. הקרחומים בשימוש 20 שנה וביחד עם מערכת הבידוד התרמית מעניקים ביצועי קירור מיטביים למוצר שלכם
?מה ההבדל בין פאנלים מבודדים בוואקום לקופסת קלקר רגילה
קופסת קלקר מספקת בידוד בסיסי בלבד
לעומת זאת, קופסת VIP של ProSpec מעניקה
• בידוד תרמי מתקדם יותר
• שמירה ארוכה יותר על הקור
• יציבות טמפרטורה גבוהה יותר
• הגנה טובה יותר בתנאי קיץ ובמהלך הובלה ממושכת

?כיצד לבחור את גודל הקופסה המתאים
בחירת הגודל תלויה ב:
• נפח המוצר
• מספר הפריטים במשלוח
• טווח הטמפרטורות הדרוש
• משך המשלוח
• כמות הקרחומים
צוות ProSpec יסייע לכם בהתאמת הפתרון המתאים לכל יישום

?האם הקופסאות מתאימות גם לקיץ ולתנאי חום קיצוניים
כן.בהחלט
אנחנו משנעים משלוחים לכל העלום בכל עונות השנה ונוכחנו לראות שהקופסאות הבנויות מפאנלים מבודדים בוואקום מפחיתים משמעותית את חדירת החום מהסביבה, ולכן מספקים הגנה טובה יותר גם כאשר הטמפרטורה החיצונית גבוהה במיוחד

?למה לבחור בפתרונות האריזה התרמית של פרוספק
האריזות שלנו פותחו לאחר שנים של ייצוא משלוחים המכילים מוצרים רגישי טמפרטורה
היתרונות כוללים:
• בידוד באמצעות Vacuum Insulated Panels (VIP)
• מערכת קרחומים ייעודית
• שמירה ממושכת על טמפרטורה מבוקרת
• התאמה למוצרים רגישים במיוחד
• הפחתת הסיכון לחריגות טמפרטורה במהלך ההובלה
• פתרון אמין לשמירה על איכות המוצר עד להגעתו ליעד

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Vacuum Insulated Thermal Box, 3kg

Product # :

BOX-002

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Description

Vacuum Insulated Thermal Box, 3kg

Optimized for:
• Life Science
• Pharmaceuticals
• Diagnostics
• Lab Samples
• Air Freight
• Food Logistics
• Agriculture
• Healthcare
• Medical Freight
• Marine Freight

about & Applications

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Introduction
Redefine your thermal logistics with our Vacuum Insulation Panels (VIP) Box.

Engineered to deliver 10x the performance of conventional materials.
This innovative, eco-friendly system provides unmatched protection for medical, aviation, marine, and general logistics shipments.

* Operating range of -70°C to +80°C
* service life of 15–20 years
* Extreme durability
* Thin, lightweight design
* 4 VIP side panels: 20cm x 15cm x 2.5cm
* 2 VIP lid & bottom panels: 25cm x 20cm x 2.5cm
* External box measuring 25.5" x 21.5" x 20.5" / 65cm × 55cm × 52cm

Ensure your critical cargo remains secure in any environment.

For more information
Background
1. What is an insulated shipping box?
An insulated shipping box is designed to protect temperature-sensitive products during transportation by minimizing heat transfer. It helps maintain a stable internal temperature, making it ideal for shipping laboratory reagents, recombinant proteins, antibodies, enzymes, vaccines, pharmaceuticals, biological samples, and other cold-chain products.

2. What makes ProSpec insulated shipping boxes different?
ProSpec insulated shipping boxes are built using Vacuum Insulated Panel (VIP) technology, which provides significantly higher thermal insulation than conventional foam or EPS (expanded polystyrene) boxes. Combined with ProSpec's specialized gel packs, they deliver superior temperature stability and extended cooling performance for critical laboratory and pharmaceutical shipments.

3. Why are Vacuum Insulated Panels (VIP) better than traditional foam insulation?
Vacuum Insulated Panels offer one of the highest thermal insulation values available for cold-chain packaging. Compared to conventional insulated boxes, VIP technology provides:
• Longer temperature retention
• Better protection against external heat
• More consistent internal temperatures
• Smaller package size with superior insulation performance
• Reduced risk of temperature excursions during transport

4. What products can be shipped in ProSpec insulated boxes?
ProSpec thermal shipping solutions are suitable for transporting:
• Recombinant proteins
• Growth factors
• Cytokines
• Antibodies
• Enzymes
• ELISA kits
• Cell culture reagents
• Biological samples
• Vaccines
• Diagnostic reagents
• Pharmaceutical products
• Temperature-sensitive laboratory materials

5. How long can an insulated shipping box maintain cold temperatures?
The cooling duration depends on several factors, including the box size, ambient temperature, shipping duration, product volume, and the number of cooling packs used.
When used with ProSpec's specialized gel packs and VIP insulation, the system is designed to maintain stable temperatures for extended shipping periods, helping protect valuable temperature-sensitive products throughout transit.

6. Are ProSpec insulated boxes suitable for international shipping?
Yes.
ProSpec insulated shipping boxes are designed for both domestic and international transportation. They help maintain required temperatures during long transit times, customs clearance, and unexpected shipping delays, making them ideal for global cold-chain logistics.

7. Can ProSpec insulated boxes maintain temperatures between 2°C and 8°C?
Yes.
When properly configured with the appropriate number and type of ProSpec cooling packs, the packaging system can be designed to support refrigerated temperature ranges such as 2–8°C, depending on shipment conditions, duration, and ambient temperatures.

8. Why should I use ProSpec cooling packs instead of standard ice packs?
ProSpec cooling packs are specifically selected to work together with the company's VIP insulated packaging system. This combination helps maximize cooling efficiency, improves temperature stability, and provides more reliable cold-chain protection compared to standard consumer-grade ice packs.

9. How do I choose the right insulated shipping box?
Selecting the appropriate insulated shipping box depends on several factors, including:
• Product dimensions
• Number of items
• Required storage temperature
• Shipping duration
• Destination climate
• Quantity of cooling packs required
ProSpec can help determine the optimal packaging configuration for your shipping application.

10. Why choose ProSpec thermal packaging solutions?
ProSpec thermal packaging are specifically developed for laboratories, biotechnology companies, pharmaceutical manufacturers, diagnostic companies, and research organizations that require reliable cold-chain transportation.
Key advantages include:
• Advanced Vacuum Insulated Panel (VIP) technology
• Superior thermal insulation
• Long-lasting temperature protection
• High-performance cooling pack solutions
• Reduced risk of temperature excursions
• Reliable protection for valuable temperature-sensitive products
• Suitable for domestic and international shipments

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Vacuum Insulated Thermal Box, 2kg

Product # :

BOX-001

Price :

Quantity :

Shipping Method :

Shipped with Ice Packs

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about & Applications

Description

Vacuum Insulated Thermal Box, 2kg

Optimized for:
• Life Science
• Pharmaceuticals
• Diagnostics
• Lab Samples
• Air Freight
• Food Logistics
• Agriculture
• Healthcare
• Medical Freight
• Marine Freight

about & Applications

More Info

Introduction
Redefine your thermal logistics with our Vacuum Insulation Panels (VIP) Box.

Engineered to deliver 10x the performance of conventional materials.
This innovative, eco-friendly system provides unmatched protection for medical, aviation, marine, and general logistics shipments.

* Operating range of -70°C to +80°C
* service life of 15–20 years
* Extreme durability
* Thin, lightweight design
* 6 VIP panels measuring 20cm x 15cm x 2,5cm / 7.9" × 5.9" × 1" each
* External box measuring 50cm x 42 cm x 65cm / 19.5" x 16.5" x 25.5"

Ensure your critical cargo remains secure in any environment.
For more information
Background
1. What is a thermal box?
A thermal box is designed to protect temperature-sensitive products during transportation by minimizing heat transfer. It helps maintain a stable internal temperature, making it ideal for shipping laboratory reagents, recombinant proteins, antibodies, enzymes, vaccines, pharmaceuticals, biological samples, and other cold-chain products.

2. What makes ProSpec thermal box different?
ProSpec thermal box is built using Vacuum Insulated Panel (VIP) which provides higher thermal insulation than conventional foam or EPS (expanded polystyrene) boxes. Combined with ProSpec's specialized gel packs, they deliver superior temperature stability and extended cooling performance for critical laboratory and pharmaceutical shipments.

3. Why are Vacuum Insulated Panels (VIP) better than traditional foam insulation?
Vacuum Insulated Panels offer one of the highest thermal insulation values available for cold-chain packaging. Compared to conventional insulated boxes, VIP technology provides:
• Longer temperature retention
• Better protection against external heat
• More consistent internal temperatures
• Smaller package size with superior insulation performance
• Reduced risk of temperature excursions during transport

4. What products can be shipped in ProSpec thermal box?
ProSpec thermal box is suitable for transporting:
• Recombinant proteins
• Growth factors
• Cytokines
• Antibodies
• Enzymes
• ELISA kits
• Cell culture reagents
• Biological samples
• Vaccines
• Diagnostic reagents
• Pharmaceutical products
• Temperature-sensitive laboratory materials

5. How long can the therma box maintain cold temperatures?
The cooling duration depends on several factors, including the box size, ambient temperature, shipping duration, product volume, and the number of cooling packs used.
When used with ProSpec's specialized gel packs and VIP insulation, the system is designed to maintain stable temperatures for extended shipping periods, helping protect valuable temperature-sensitive products throughout transit.

6. Is ProSpec thermal boxe suitable for international shipping?
Yes.
ProSpec insulated shipping boxes are designed for both domestic and international transportation. They help maintain required temperatures during long transit times, customs clearance, and unexpected shipping delays, making them ideal for global cold-chain logistics.

7. Can ProSpec thermal box maintain temperatures between 2°C-8°C?
Yes.
When properly configured with the appropriate number and type of ProSpec cooling packs, the packaging system can be designed to support refrigerated temperature ranges such as 2–8°C, depending on shipment conditions, duration, and ambient temperatures.

8. Why should I use ProSpec ice packs instead of standard ice packs?
ProSpec ice packs are specifically selected to work together with the company's therma box. This combination maximize cooling efficiency, improves temperature stability, and provides more reliable cold-chain protection compared to standard consumer-grade ice packs.

9. How do I choose the right thermal box ?
Selecting the appropriate insulated shipping box depends on several factors, including:
• Product dimensions
• Number of items
• Required storage temperature
• Shipping duration
• Destination climate
• Quantity of cooling packs required
ProSpec can determine the optimal packaging configuration for your shipping application.

10. Why choose ProSpec thermal box packaging solutions?
ProSpec thermal packaging are developed for laboratories, biotechnology companies, pharmaceutical manufacturers, diagnostic companies, and research organizations that require reliable cold-chain transportation.
Key advantages include:
• Advanced Vacuum Insulated Panel (VIP) technology
• Superior thermal insulation
• Long-lasting temperature protection
• High-performance cooling pack solutions
• Reduced risk of temperature excursions
• Reliable protection for valuable temperature-sensitive products
• Suitable for domestic and international shipments

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

מארז מבודד 2 ק"ג

Product # :

BOX-004

Price :

Quantity :

Shipping Method :

Shipped with Ice Packs

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Description

קופסה תרמית מבודדת בוואקום- 2 ק"ג
אופטימלית עבור:
• מדעי החיים
• תרופות
• אבחון
• דגימות מעבדה
• הובלה אווירית
• לוגיסטיקת מזון
• חקלאות
• שירותי בריאות
• הובלה רפואית
• הובלה ימית

about & Applications

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Introduction
הגדירו מחדש את הלוגיסטיקה התרמית שלכם עם קופסת פאנלים בבידוד ואקום שלנו
(VIP)
תוכננה לספק ביצועים פי 10 מחומרים קונבנציונליים.
מערכת חדשנית וידידותית לסביבה זו מספקת הגנה שאין שני לה למשלוחים רפואיים, תעופה, ימיים ולוגיסטיקה כללית.
* טווח פעולה של מינוס 70 מעלות עד 80 מעלות
* אורך חיים של 15-20 שנים
* עמידות יוצאת דופן
* עיצוב דק וקל משקל
* שישה פאנלים במידות 20/15/2.5 ס"מ - 7.9/5.9/1 אינץ' כל אחד
* קופסה חיצונית
במידות 50/42/65 ס"מ - 19.5/16.5/25.5 אינץ

וודא שהמטען הקריטי שלך יישאר מאובטח בכל סביבה

למידע נוסף
Background
?מהי קופסה תרמית מבודדת ולמה היא משמשת
קופסה תרמית מבודדת מיועדת להגן על מוצרים רגישים לטמפרטורה במהלך ההובלה. היא מסייעת לשמור על טמפרטורה יציבה לאורך זמן ומתאימה לשינוע של חלבונים, נוגדנים, ריאגנטים, ערכות אבחון, תרופות, דגימות ביולוגיות ומוצרים נוספים הדורשים שרשרת קירור רציפה

?למה לבחור קופסה עם פאנלים מבודדים בוואקום
פאנלים מבודדים בוואקום מספקים רמת בידוד גבוהה משמעותית בהשוואה לחומרי בידוד מסורתיים כגון קלקר.
המשמעות ברורה:
הגנה טובה יותר מפני טמפרטורה גבוהה
זמן קירור ארוך יותר
אפשרות להשתמש באריזה קטנה יותר עם ביצועים גבוהים

?כמה זמן הקופסה שומרת על הטמפרטורה
משך השמירה תלוי בגודל האריזה, סוג הקרחומים, כמות המוצר וטמפרטורת הסביבה
בשילוב הקרחומים הייעודיים של חברת ProSpec ופאנלים מבוסדדם בוואקום, ניתן לשמור על טמפרטורה יציבה לאורך זמן גם במהלך משלוחים ממושכים. חברת ProSpec מייצאת לכל העולם עם וותק שלמעלה מ 20 שנה

?אילו מוצרים ניתן לשלוח בקופסאות התרמיות של פרוספק
הקופסאות מתאימות לשינוע של:
• חלבונים רקומביננטיים
• ציטוקינים
• גורמי גדילה
• נוגדנים
• אנזימים
• ערכות ELISA
• דגימות ביולוגיות
• תרופות
• חיסונים
• מוצרים רפואיים ומעבדתיים רגישים לטמפרטורה

?האם הקופסה מתאימה למשלוחים בינלאומיים
בהחלט כן.
הקופסה מיועדות למשלוחים ארציים ובינלאומיים ומתאימה למצבים שבהם החבילה עלולה להיות ימים בדרכה ללקוח, תוך שמירה על טמפרטורה קרה

?האם יש צורך להשתמש בקרחומים מיוחדים
אנחנו ממליצים. כן
לקבלת הביצועים הטובים ביותר מומלץ להשתמש בקרחומים הייעודיים של חברת ProSpec. הקרחומים בשימוש 20 שנה וביחד עם מערכת הבידוד התרמית מעניקים ביצועי קירור מיטביים למוצר שלכם

?מה ההבדל בין פאנלים מבודדים בוואקום לקופסת קלקר רגילה
קופסת קלקר מספקת בידוד בסיסי בלבד
לעומת זאת, קופסת VIP של ProSpec מעניקה
• בידוד תרמי מתקדם יותר
• שמירה ארוכה יותר על הקור
• יציבות טמפרטורה גבוהה יותר
• הגנה טובה יותר בתנאי קיץ ובמהלך הובלה ממושכת

?כיצד לבחור את גודל הקופסה המתאים
בחירת הגודל תלויה ב:
• נפח המוצר
• מספר הפריטים במשלוח
• טווח הטמפרטורות הדרוש
• משך המשלוח
• כמות הקרחומים
צוות ProSpec יסייע לכם בהתאמת הפתרון המתאים לכל יישום

?האם הקופסאות מתאימות גם לקיץ ולתנאי חום קיצוניים
כן.בהחלט
אנחנו משנעים משלוחים לכל העלום בכל עונות השנה ונוכחנו לראות שהקופסאות הבנויות מפאנלים מבודדים בוואקום מפחיתים משמעותית את חדירת החום מהסביבה, ולכן מספקים הגנה טובה יותר גם כאשר הטמפרטורה החיצונית גבוהה במיוחד

?למה לבחור בפתרונות האריזה התרמית של פרוספק
האריזות שלנו פותחו לאחר שנים של ייצוא משלוחים המכילים מוצרים רגישי טמפרטורה
היתרונות כוללים:
• בידוד באמצעות Vacuum Insulated Panels (VIP)
• מערכת קרחומים ייעודית
• שמירה ממושכת על טמפרטורה מבוקרת
• התאמה למוצרים רגישים במיוחד
• הפחתת הסיכון לחריגות טמפרטורה במהלך ההובלה
• פתרון אמין לשמירה על איכות המוצר עד להגעתו ליעד

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Chromobox Homolog 3 Human Recombinant

Chromobox homolog 3 (Drosophila HP1 gamma), Heterochromatin protein 1 homolog gamma, Modifier 2 protein, HP1 gamma homolog, HECH, HP1Hs-gamma.

Product # :

PRO-1057

Price :

Quantity :

Shipping Method :

Shipped with Ice Packs

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source
formulation
purity
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Description

CBX3 Human Recombinant produced in E. coli is a single polypeptide chain containing 207 amino acids (1-183) and having a molecular mass of 23.4kDa.CBX3 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Formulation

The CBX3 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM Nacl, 1mM DTT and 20% glycerol.

Purity

Greater than 90% as determined by SDS-PAGE.

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Introduction
CBX3 takes part in transcriptional silencing in heterochromatin-like complexes. CBX3 identifies and binds histone H3 tails methylated at 'Lys-9', thereby create an epigenetic repression. Additionally, CBX3 takes part in the formation of functional kinetochore by interacting with MIS12 complex proteins.
Synonyms
Chromobox homolog 3 (Drosophila HP1 gamma), Heterochromatin protein 1 homolog gamma, Modifier 2 protein, HP1 gamma homolog, HECH, HP1Hs-gamma.
Physical Appearance
Sterile Filtered colorless solution.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMASNKT TLQKMGKKQN GKSKKVEEAE PEEFVVEKVL DRRVVNGKVE YFLKWKGFTD ADNTWEPEEN LDCPELIEAF LNSQKAGKEK DGTKRKSLSD SESDDSKSKK KRDAADKPRG FARGLDPERI IGATDSSGEL MFLMKWKDSD EADLVLAKEA NMKCPQIVIA FYEERLTWHS CPEDEAQ.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Sonic HedgeHog Human Recombinant

SHH, HHG-1, HHG1, Sonic hedgehog protein, TPT, HLP3, HPE3, SMMCI, TPTPS, MCOPCB5.

Product # :

CYT-676

Price :

Quantity :

Shipping Method :

Shipped at Room temp

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source
formulation
purity
biological activity
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Description

Sonic HedgeHog Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids and having a molecular mass of 20.2kDa. The Cys at position 2 has been substituted with 2 Ile’s.

Source

Escherichia Coli.

Formulation

SHH is lyophilized from 10mM Na3PO4, pH 7.5.

Purity

Greater than 95.0% as determined by SDS-PAGE.

Biological Activity

The ED50 is measured by the dose-dependent induction of alkaline phosphatase production by CCL-226 fibroblasts and is 1.47μg/ml corresponding to a specific activity of 680U/mg.

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Introduction
Recombinant Human Sonic Hedgehog is part of a small group of secreted proteins that are vital for development in both vertebrates and invertebrates. 3 mammalian hedgehog genes (sonic, desert, Indian) share about 60% homology. The Human Sonic Hedgehog is 99% homologous to the mouse gene. Sonic HedgeHog is a protein that is vital in guding the early embryo. It has been associated as the major inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Sonic HedgeHog binds to the patched receptor, which functions in association with smoothened, to activate the transcription of target genes. In the absence of sonic HedgeHog, patched receptor represses the constitutive signaling activity of smoothened. Sonic HedgeHog also regulates another factor, the gli oncogene. Sonic HedgeHog intercellular signal is essential for a various patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Sonic HedgeHog exhibits both floor plate- and motor neuron-inducing activity. Mutations in a long-range Sonic HedgeHog enhancer located in an intron of the limb region 1 gene result in preaxial polydactyly.
Synonyms
SHH, HHG-1, HHG1, Sonic hedgehog protein, TPT, HLP3, HPE3, SMMCI, TPTPS, MCOPCB5.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Stability
Lyophilized Human Sonic HedgeHog although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Sonic HedgeHog should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Solubility
It is recommended to reconstitute the lyophilized SHH in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Amino Acid Sequence
MIIGPGRGFG KRRHPKKLTP LAYKQFIPNV AEKTLGASGR YEGKISRNSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDKLNALAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRALDITTS DRDRSKYGML ARLAVEAGFD WVYYESKAHI HCSVKAENSV AAKSGGCFP

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Heme Oxygenase 1, Mouse Anti Human

HO-1, HSP32, bK286B10, HMOX-1, Heme oxygenase 1, HMOX1, HO, HO1.

Product # :

ANT-683

Price :

Quantity :

Shipping Method :

Shipped with Ice Packs

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formulation
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Formulation

1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.

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Introduction
HMOX1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is then converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HMOX1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme Oxygenase-1 is involved in the regulation of cardiovascular function and its adaptive response to a variety of stressors. HMOX1 is induced in the colon of ulcerative colitis. HMOX1 is found to overexpress with a higher extent of intraplaque angiogenesis implies a multi-faceted role for HMOX1 in modulating the progression of atherosclerosis. HMOX1 expression reduced LPS-stimulated secretion of MCP-1, IL-6, IL-10, and TNF-alpha in murine and human macrophages.
Synonyms
HO-1, HSP32, bK286B10, HMOX-1, Heme oxygenase 1, HMOX1, HO, HO1.
Physical Appearance
Sterile filtered colorless solution.
Immunogen
Anti-human HMOX1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HMOX1 amino acids 1-266 purified from E. coli.
Ig Subclass
Mouse IgG2a heavy chain and K light chain.
Clone
PAT1D6AT.
Applications
HMOX1 antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Type
Mouse Anti Human Monoclonal.
Storage Procedures
For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.
Purification Method
HMOX1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

DEAD Box Protein 56 Human Recombinant

DEAD (Asp-Glu-Ala-Asp) Box Helicase 56, 61-Kd Nucleolar Helicase, DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 56, DDX26, Nucleolar Helicase Of 61 KDa, DEAD-Box RNA Helicase, DDX21, Probable ATP-Dependent RNA Helicase DDX56, NOH61, Putative Nucleolar RNA Helicase, ATP-Dependent 61 KDa Nucleolar RNA Helicase, EC 3.6.4.13, DEAD Box Protein 21, EC 3.6.1, DEAD Box Protein 56.

Product # :

PRO-1723

Price :

Quantity :

Shipping Method :

Shipped with Ice Packs

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description
source
formulation
purity
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Description

DDX56 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 570 amino acids (1-547 a.a) and having a molecular mass of 64kDa.DDX56 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Formulation

DDX56 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.4M urea.

Purity

Greater than 85.0% as determined by SDS-PAGE.

More Info

Introduction
DEAD Box Protein 56 (DDX56) belongs to the DEAD box protein family. DEAD box proteins, categorized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. DEAD box proteins are implicated in several cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based upon their distribution patterns, certain members of this family are assumed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX56 exhibits ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles.
Synonyms
DEAD (Asp-Glu-Ala-Asp) Box Helicase 56, 61-Kd Nucleolar Helicase, DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 56, DDX26, Nucleolar Helicase Of 61 KDa, DEAD-Box RNA Helicase, DDX21, Probable ATP-Dependent RNA Helicase DDX56, NOH61, Putative Nucleolar RNA Helicase, ATP-Dependent 61 KDa Nucleolar RNA Helicase, EC 3.6.4.13, DEAD Box Protein 21, EC 3.6.1, DEAD Box Protein 56.
Physical Appearance
Sterile Filtered clear solution.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMEDSEAL GFEHMGLDPR LLQAVTDLGW SRPTLIQEKA IPLALEGKDL LARARTGSGK TAAYAIPMLQ LLLHRKATGP VVEQAVRGLV LVPTKELARQ AQSMIQQLAT YCARDVRVAN VSAAEDSVSQ RAVLMEKPDV VVGTPSRILS HLQQDSLKLR DSLELLVVDE ADLLFSFGFE EELKSLLCHL PRIYQAFLMS ATFNEDVQAL KELILHNPVT LKLQESQLPG PDQLQQFQVV CETEEDKFLL LYALLKLSLI RGKSLLFVNT LERSYRLRLF LEQFSIPTCV LNGELPLRSR CHIISQFNQG FYDCVIATDA EVLGAPVKGK RRGRGPKGDK ASDPEAGVAR GIDFHHVSAV LNFDLPPTPE AYIHRAGRTA RANNPGIVLT FVLPTEQFHL GKIEELLSGE NRGPILLPYQ FRMEEIEGFR YRCRDAMRSV TKQAIREARL KEIKEELLHS EKLKTYFEDN PRDLQLLRHD LPLHPAVVKP HLGHVPDYLV PPALRGLVRP HKKRKKLSSS CRKAKRAKSQ NPLRSFKHKG KKFRPTAKPS.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

DEAD Box Protein 39A Human Recombinant

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A, BAT1, BAT1L, DDX39, DDXL, URH49, ATP-dependent RNA helicase DDX39A, DEAD box protein 39, Nuclear RNA helicase URH49, DDX39A.

Product # :

PRO-1990

Price :

Quantity :

Shipping Method :

Shipped with Ice Packs

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source
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purity
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Description

DDX39A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 274 amino acids (1-249 a.a) and having a molecular mass of 31kDa. DDX39A is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Formulation

DDX39A protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.

Purity

Greater than 80.0% as determined by SDS-PAGE.

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Introduction
DDX39A which is a part of the DEAD box protein family is characterized by the conserved motif Asp-Glu-Ala-Asp. This pattern is implicated in a various cellular processes involving alteration of RNA secondary structure, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Several members of the DEAD box protein family are taking part in embryogenesis, spermatogenesis, and cellular growth and division.
Synonyms
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A, BAT1, BAT1L, DDX39, DDXL, URH49, ATP-dependent RNA helicase DDX39A, DEAD box protein 39, Nuclear RNA helicase URH49, DDX39A.
Physical Appearance
Sterile Filtered colorless solution.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSEFMAEQD VENDLLDYDE EEEPQAPQES TPAPPKKDIK GSYVSIHSSG FRDFLLKPEL LRAIVDCGFE HPSEVQHECI PQAILGMDVL CQAKSGMGKT AVFVLATLQQ IEPVNGQVTV LVMCHTRELA FQISKEYERF SKYMPSVKVS VFFGGLSIKK DEEVLKKNCP HVVVGTPGRI LALVRNRSFS LKNVKHFVLD ECDKMLEQLD MRRDVQEIFR LTPHEKQCMM FSATLSKDIR PVCRKFMQDP MEVF.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Chromobox Homolog 5 Human Recombinant

Chromobox homolog 5 (HP1 alpha homolog, Drosophila), Heterochromatin protein 1 homolog alpha, HP1Hs alpha, HP1 alpha homolog.

Product # :

PRO-1062

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Description

CBX5 Human Recombinant produced in E. coli is a single polypeptide chain containing 215 amino acids (1-191) and having a molecular mass of 24.8kDa.CBX5 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Formulation

The CBX5 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM Nacl, 1mM DTT and 30% glycerol.

Purity

Greater than 90% as determined by SDS-PAGE.

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Introduction
CBX5 belongs to the heterochromatin protein family. CBX5 is enriched in the heterochromatin and linked with centromeres. CBX5 takes part in the creation of functional kinetochore by interaction with important kinetochore proteins. CBX5 has a pseudogene situated on chromosome 3. Additionaly, The CBX5 proteins reconnect with chromatin at the end of mitosis, as Histone H3 is dephosphorylated.
Synonyms
Chromobox homolog 5 (HP1 alpha homolog, Drosophila), Heterochromatin protein 1 homolog alpha, HP1Hs alpha, HP1 alpha homolog.
Physical Appearance
Sterile Filtered colorless solution.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMGKKTK RTADSSSSED EEEYVVEKVL DRRVVKGQVE YLLKWKGFSE EHNTWEPEKN LDCPELISEF MKKYKKMKEG ENNKPREKSE SNKRKSNFSN SADDIKSKKK REQSNDIARG FERGLEPEKI IGATDSCGDL MFLMKWKDTD EADLVLAKEA NVKCPQIVIA FYEERLTWHA YPEDAENKEK ETAKS.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Heme Oxygenase-2 Human Recombinant

EC 1.14.99.3, HO2, Heme oxygenase 2, HO-2, HMOX2.

Product # :

ENZ-478

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purity
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Description

HMOX2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 264 amino acids (1-264 a.a.) and having a molecular mass of 30.5 kDa. HMOX2 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Formulation

HMOX2 solution containing 20mM Tris pH-8, 1mM DTT and 10% glycerol.

Purity

Greater than 90% as determined by SDS-PAGE.

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Introduction
HMOX2 cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently transferred to bilirubin by biliverdin reductase. Under physiological conditions, the activity of HMOX2 is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. HMOX2 participates in the production of carbon monoxide in the brain where it operates as a neurotransmitter. HMOX2 is an essential enzyme in heme catabolism and is involved in cellular response to oxidative stress.
Synonyms
EC 1.14.99.3, HO2, Heme oxygenase 2, HO-2, HMOX2.
Physical Appearance
Sterile filtered colorless solution.
Stability
HMOX2 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
Amino Acid Sequence
SAEVETSEG VDESEKKNSG ALEKENQMRM ADLSELLKEG TKEAHDRAEN TQFVKDFLKG NIKKELFKLA TTALYFTYSA LEEEMERNKD HPAFAPLYFP MELHRKEALT KDMEYFFGEN WEEQVQCPKA AQKYVERIHY IGQNEPELLV AHAYTRYMGD LSGGQVLKKV AQRALKLPST GEGTQFYLFE NVDNAQQFKQ LYRARMNALD LNMKTKERIV EEANKAFEYN MQIFNELDQA GSTLARETLE DGFPVHDGKG DMRK.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Hepatitis B Surface Antigen, adw Recombinant

Product # :

HBS-872

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Description

HbsAg adw produced Pichia Pastoris, having a molecular weight of approximately 24.0 kDa as shown on SDS-PAGE.

Source

Pichia Pastoris.

Formulation

Sterile Filtered solution containing 20mM Phosphate Buffer, 154mM sodium chloride, pH 7.1.

Purity

Greater than 95.0% as determined by SDS-PAGE.

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Introduction
HBsAg is the surface antigenof the Hepatitis-B-Virus (HBV). The capsidof a virus has different surface proteins from the rest of the virus. The antigen is a protein that binds specifically on one of these surface proteins. It is commonly referred to as the Australian Antigen.
Physical Appearance
Sterile Filtered pale solution.
Stability
HBsAg Should be stored at 4°C.DO NOT FREEZE.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Interferon Induced With Helicase C Domain 1 Human Recombinant

Interferon-induced helicase C domain-containing protein 1, Clinically amyopathic dermatomyositis autoantigen 140 kDa, CADM-140 autoantigen, Helicase with 2 CARD domains, Helicard, Interferon-induced with helicase C domain protein 1, Melanoma differentiation-associated protein 5, MDA-5, Murabutide down-regulated protein, RIG-I-like receptor 2, RLR-2, RNA helicase-DEAD box protein 116, IFIH1, MDA5, RH116, Hlcd, IDDM19.

Product # :

PRO-1505

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Description

IFIH1 Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 152,000 Dalton. IFIH1 is expressed with a -10xHis tag at N-terminus and purified by proprietary chromatographic techniques.

Source

Sf9 Insect Cells.

Formulation

IFIH1 is supplied in 20mM HEPES buffer pH-7.9, 550mM NaCl and 6M Urea.

Purity

Greater than 93.0% as determined by SDS-PAGE.

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Introduction
IFIH1 is a DEAD box protein which is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be attained by therapy with both these agents; treatment with either agent alone only achieves reversible differentiation. DEAD box proteins are implicated in several cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.
Synonyms
Interferon-induced helicase C domain-containing protein 1, Clinically amyopathic dermatomyositis autoantigen 140 kDa, CADM-140 autoantigen, Helicase with 2 CARD domains, Helicard, Interferon-induced with helicase C domain protein 1, Melanoma differentiation-associated protein 5, MDA-5, Murabutide down-regulated protein, RIG-I-like receptor 2, RLR-2, RNA helicase-DEAD box protein 116, IFIH1, MDA5, RH116, Hlcd, IDDM19.
Physical Appearance
Sterile Filtered clear solution.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Heme Oxygenase 1 Human Recombinant

HO-1, HSP32, bK286B10, HMOX-1, Heme oxygenase 1, HMOX1, HO, HO1.

Product # :

ENZ-392

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Description

HO-1 Human Recombinant protein produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 274 amino acids (1-266) and having a molecular mass of 31.4 kDa. HO-1 is fused to an 8 amino acid His Tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Formulation

HMOX1 1 mg/ml solution containing 20mM Tris-HCl pH-8, 50mM NaCl, 0.1mM PMSF and 10% glycerol.

Purity

Greater than 95.0% as determined by SDS-PAGE.

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Introduction
HMOX1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is then converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HMOX1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme Oxygenase-1 is involved in the regulation of cardiovascular function and its adaptive response to a variety of stressors. HMOX1 is induced in the colon of ulcerative colitis. HMOX1 is found to overexpress with a higher extent of intraplaque angiogenesis implies a multi-faceted role for HMOX1 in modulating the progression of atherosclerosis. HMOX1 expression reduced LPS-stimulated secretion of MCP-1, IL-6, IL-10, and TNF-alpha in murine and human macrophages.
Synonyms
HO-1, HSP32, bK286B10, HMOX-1, Heme oxygenase 1, HMOX1, HO, HO1.
Physical Appearance
Sterile filtered colorless solution.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid Sequence
MERPQPHSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV MASLYHIYVA LEEEIERNKE SPVFAPVYFP EELHRKAALEQDLAFWYGPR WQEVIPYTPA MQRYVKRLHE VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALDLPSS GEGLAFFTFP NIASATKFKQLYRSRMNSLE MTPAVRQRVI EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA SNKVQDSAPV ETPRGKPPLN TRSQAPLEHHHHHH.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

High-Mobility Group Box 2 Human Recombinant

High mobility group (nonhistone chromosomal) protein B2, h mobility group box 2, HMG2.

Product # :

PRO-888

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source
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Description

HMGB2 Human Recombinant produced in Baculovirus is a single polypeptide chain containing 232 amino acids (1-209) and having a molecular mass of 26.4 kDa.The HMGB2 is fused to a 23 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Source

Baculovirus.

Formulation

The HMGB2 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 0.1M NaCl and 30% glycerol.

Purity

Greater than 90% as determined by SDS-PAGE.

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Introduction
HMGB2 belongs to the non-histone chromosomal high-mobility group protein family which are chromatin-associated and highly spread in the nucleus of higher eukaryotic cells. HMGB2 can successfully bend DNA and form DNA circles which indicates that HMGB2 facilitates cooperative interactions between cis-acting proteins by promoting DNA flexibility. Additionally, HMGB2 takes part in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
Synonyms
High mobility group (nonhistone chromosomal) protein B2, h mobility group box 2, HMG2.
Physical Appearance
Sterile Filtered colorless solution.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH TGSMGKGDPN KPRGKMSSYA FFVQTCREEH KKKHPDSSVN FAEFSKKCSE RWKTMSAKEK SKFEDMAKSD KARYDREMKN YVPPKGDKKG KKKDPNAPKR PPSAFFLFCS EHRPKIKSEH PGLSIGDTAK KLGEMWSEQS AKDKQPYEQK AAKLKEKYEK DIAAYRAKGK SEAGKKGPGR PTGSKKKNEP EDEEEEEEEE DEDEEEEDED EE.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Bone Morphogenetic Protein-4 Human Recombinant

BMP4, ZYME, BMP2B, BMP2B1.

Product # :

CYT-361

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Shipping Method :

Shipped at Room temp

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Description

Bone Morphogenetic Protein-4 Human Recombinant produced in E.Coli is a monomeric, non-glycosylated, Polypeptide chain containing 116 amino acids and having a molecular mass of 13kDa. The BMP-4 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Formulation

BMP-4 was lyophilized from a 0.2µm filtered concentrated (1mg/ml) solution in 20mM Na2CO3 buffer, pH 9.0.

Purity

Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

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Introduction
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
Synonyms
BMP4, ZYME, BMP2B, BMP2B1.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Stability
Lyophilized Bone Morphogenetic Protein-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP4 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Solubility
It is recommended to reconstitute the lyophilized Bone Morphogenetic Protein-4 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Amino Acid Sequence
SPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR.
Background
What You Should Know About Bone Morphogenetic Protein-4 (BMP-4) Human Recombinant
As part of the transforming growth factor-beta (TGF-β) superfamily, Bone morphogenetic protein-4 (BMP-4) participates in multiple developmental processes, from embryogenesis to bone and cartilage formation.
Since this signaling protein is involved in many physiological processes, its laboratory-produced version has been studied for different medical applications. Additionally, a reduction in BMP-4 expression has been associated with multiple diseases, leading to further research into its potential therapeutic benefits.
Are you interested in learning more about Bone Morphogenetic Protein-4 (BMP-4) human recombinant? Read on to find more information!
How Does Bone Morphogenetic Protein-4 (BMP-4) Work?
Bone Morphogenetic Protein-4 (BMP-4) regulates microRNAs miR-494 and miR-126-5p expression, controlling endothelial cells' involvement and function in angiogenesis. As such, it has diverse effects on cell growth, differentiation, and survival.
The Role of BMP-4
This protein emits signals that promote the formation of different tissues and organs, including the bones and cartilage, kidneys, teeth, and the neural tube. In other words, it's essential for the development of the heart, skeleton, and central nervous system.
However, the role of BMP-4 goes beyond these processes. It participates in different physiological activities, such as:
- Embryonic development
- Wound healing
- Bone remodeling
- Immune response modulation
- Tissue repair
- Cardiac development and function
What Is Bone Morphogenetic Protein-4 (BMP-4) Human Recombinant?
To replicate the effects of the BMP4 found in humans and explore its possible therapeutic applications, many laboratories have started producing this protein in Chinese hamster ovary (CHO) cells.
As mentioned, decreased BMP-4 expression has been associated with different diseases, including bone disorders, fibrosis, and cancer, which can cause other conditions, such as organ dysfunction.
More research is needed, but BMP-4 human recombinant (rhBMP4) produced in CHO has the potential to address these diseases and could be used for other medical applications. These are some examples:
- Cancer therapy
- Development of engineered tissues and organs
- Bone regeneration for the treatment of osteoporosis and nonunion fractures
- Bone growth and fusion in spinal fusion surgeries (the U.S. Food and Drug Administration approved some bone morphogenetic proteins for these procedures)
- Promotion of tissue repair and regeneration
Final Thoughts BMP-4
Although BMP-4 human recombinant produced in CHO offers potential benefits, several challenges remain, including possible side effects, as high doses can cause inflammation, bone overgrowth, and other issues.
However, the long-term effects of rhBMP4 are still under investigation. Further research will provide solutions to address these challenges and allow experts to explore this laboratory-produced protein's power in different medical fields.
What is the molecular weight/Mw of BMP4 Protein?
BMP4 Protein has a total Mw of 13kDa.

What is the source or expression system of BMP4 Protein?
Escherichia Coli.

What is the Purity of BMP4 Protein?
BMP4 Protein is >95% pure as determined by SDS-PAGE.

What is the Biological Activity of BMP4 Protein?
The biological functionality of BMP4 Protein will be determined in the future.

What is the amino acid sequence of BMP4 Protein?
SPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR.

What applications can BMP4 Protein be used in?
BMP4 Protein can probably be used in western blot, ELISA and Lateral Flow.

What is the endotoxin level for BMP4 Protein?
The endotoxin level is minimal, BMP4 Protein was purified using conventional chromatography techniques.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

High Mobility Group AT-Hook 1 Human Recombinant

High mobility group protein HMG-I/HMG-Y, HMG-I(Y), High mobility group AT-hook protein 1, High mobility group protein A1, High mobility group protein R , HMGA1, HMGIY, HMG-R, HMGA1A.

Product # :

PRO-887

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Description

HMGA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 115 amino acids (1-107 a.a.) and having a molecular mass of 12.7kDa (Molecular weight on SDS-PAGE will appear higher).HMGA1 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Formulation

HMGA1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 50% glycerol and 0.2M NaCl.

Purity

Greater than 90.0% as determined by SDS-PAGE.

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Introduction
High mobility group protein HMG-I/HMG-Y (HMGA1) belongs to the non-histone chromosomal high mobility group protein (HMG) family. HMGA1 is composed of a highly conserved AT-hook DNA-binding domain which mediates binding to AT-rich sequences in the minor groove of chromosomal DNA. HMGA1 functions as an architectural chromatin-binding transcription factor modifying the conformation of DNA by modulating nuclear protein-DNA complexes. Furthermore, HMGA1 is involved in numerous cellular processes including growth regulation, viral induction of beta-IFN gene and regulation of inducible gene transcription.
Synonyms
High mobility group protein HMG-I/HMG-Y, HMG-I(Y), High mobility group AT-hook protein 1, High mobility group protein A1, High mobility group protein R , HMGA1, HMGIY, HMG-R, HMGA1A.
Physical Appearance
Sterile filtered colorless solution.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid Sequence
MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE VPTPKRPRGR PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ ESSEEEQLEH HHHHH.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Description:

Interferon-Omega 1 Human Recombinant, HEK

IFN omega-1, IFN alpha-II-1, IFNW1.

Product # :

CYT-1225

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biological activity
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Description

IFNW1 Human Recombinant is a single, glycosylated, polypeptide chain (22-195 a.a) containing a total of 180 amino acids and having a molecular mass of 20.9 kDa. IFNW1 is fused to a 6 a.a his-Tag at C-terminus and is purified by proprietary chromatographic techniques.

Source

HEK293 Cells.

Formulation

The IFNW1 solution (1mg/ml) contains 10% Glycerol and Phosphate-Buffered Saline (pH 7.4).

Purity

Greater than 95.0% as determined by SDS-PAGE.

Biological Activity

The ED50 is ≤0.07 ng/ml, measured in a cytotoxicity assay using TF-1 human erythroleukemic cells .

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Synonyms
IFN omega-1, IFN alpha-II-1, IFNW1.
Physical Appearance
Sterile Filtered colorless solution.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid Sequence
LGCDLPQNHG LLSRNTLVLL HQMRRISPFL CLKDRRDFRF PQEMVKGSQL QKAHVMSVLH EMLQQIFSLF HTERSSAAWN MTLLDQLHTG LHQQLQHLET CLLQVVGEGE SAGAISSPAL TLRRYFQGIR VYLKEKKYSD CAWEVVRMEI MKSLFLSTNM QERLRSKDRD LGSSHHHHHH.
Background
Interferons, a family of signaling proteins, play a pivotal role in the immune system’s defense against viral infections and other threats. Among these, Interferon W1 (IFNW1), a member of the Type I interferon family, has emerged as a key player in orchestrating antiviral responses and modulating immune reactions. This research embarks on a detailed exploration of the IFNW1 protein, unveiling its structural intricacies, signaling pathways, and its broader implications in immune regulation and disease. By delving into IFNW1, scientists aim to comprehend the nuances of its functions, decipher its interactions within the complex interferon network, and explore its potential applications in therapeutic interventions and beyond.
Structural Insights into IFNW1:
IFNW1, like other Type I interferons, exhibits a unique tertiary structure that enables it to interact with specific cell surface receptors. This interaction triggers a cascade of events, leading to the activation of various antiviral genes and immune modulatory pathways. Understanding the structural basis of IFNW1 is crucial for elucidating its binding affinities, biological activities, and its significance in immune responses.
Signaling Pathways and Antiviral Defense:
IFNW1 engages with its cognate receptors, initiating Janus kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) signaling pathways. This activation leads to the transcription of interferon-stimulated genes (ISGs) with potent antiviral properties. IFNW1’s ability to induce an antiviral state in infected and neighboring cells is fundamental for restricting viral replication and curtailing the spread of infections. Additionally, IFNW1 plays a role in modulating adaptive immune responses, contributing to the broader immune defense mechanisms.
IFNW1 in Immunomodulation and Disease:
Beyond its antiviral functions, IFNW1 is implicated in immunomodulation and disease pathogenesis. Dysregulation of IFNW1 signaling is associated with autoimmune disorders, including lupus and rheumatoid arthritis, highlighting its involvement in immune-related diseases. Moreover, IFNW1 is being explored in cancer immunotherapy, where its ability to modulate the tumor microenvironment and enhance immune surveillance presents opportunities for novel treatment strategies.
Therapeutic Potential and Future Prospects:
The unique properties of IFNW1, particularly its role in immune regulation and antiviral defense, position it as a potential therapeutic target. Research efforts are directed towards harnessing its immunomodulatory functions for developing therapies against infectious diseases, autoimmune disorders, and certain cancers. Additionally, understanding IFNW1’s interactions with other components of the immune system opens avenues for innovative approaches in personalized medicine and targeted immunotherapies.
IFNW1 Protein, as an integral component of the interferon network, stands as a sentinel in the body’s defense against viral invasions and immune dysregulations. Its multifaceted roles in antiviral defense, immune modulation, and disease pathogenesis underscore its significance in biology and medicine. As researchers delve deeper into the intricacies of IFNW1, they pave the way for innovative therapies, immunomodulatory interventions, and a deeper understanding of immune responses. This research not only illuminates the pivotal role of IFNW1 but also holds the promise of transformative advancements in medicine, shaping the future of immunology and disease therapeutics.
What is the molecular weight/Mw of IFNW1 HUMAN, HEK Protein?
IFNW1 HUMAN, HEK Protein has a total Mw of 20.9kDa.

What is the source or expression system of IFNW1 HUMAN, HEK Protein?
HEK293 Cells.

What is the Purity of IFNW1 HUMAN, HEK Protein?
IFNW1 HUMAN, HEK Protein is >95% pure as determined by SDS-PAGE.

What is the Biological Activity of IFNW1 HUMAN, HEK Protein?
The ED50 is ≤0.07 ng/ml, measured in a cytotoxicity assay using TF-1 human erythroleukemic cells .

What is the amino acid sequence of IFNW1 HUMAN, HEK Protein?
LGCDLPQNHG LLSRNTLVLL HQMRRISPFL CLKDRRDFRF PQEMVKGSQL QKAHVMSVLH EMLQQIFSLF HTERSSAAWN MTLLDQLHTG LHQQLQHLET CLLQVVGEGE SAGAISSPAL TLRRYFQGIR VYLKEKKYSD CAWEVVRMEI MKSLFLSTNM QERLRSKDRD LGSSHHHHHH.

What applications can IFNW1 HUMAN, HEK Protein be used in?
IFNW1 HUMAN, HEK Protein can probably be used in western blot, ELISA and Lateral Flow.

What is the endotoxin level for IFNW1 HUMAN, HEK Protein?
The endotoxin level is minimal, IFNW1 HUMAN, HEK Protein was purified using conventional chromatography techniques.

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