Peroxisomal Biogenesis Factor

Peroxisomal Biogenesis Factor

Peroxisomal Biogenesis Factor

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  • View Data Sheet

    Description:

    Peroxisomal Biogenesis Factor 26 Human Recombinant

    PBD7A, PBD7B, PEX26M1T, Pex26pM1T, Peroxisome assembly protein 26, PEX26.

    Product # :

    PRO-1544

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    Description

    PEX26 Human Recombinant produced in E. coli is a single polypeptide chain containing 269 amino acids (1-246) and having a molecular mass of 29.3kDa. PEX26 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The PEX26 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.

    Purity

    Greater than 90% as determined by SDS-PAGE.

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    • Introduction

      Peroxisomal Biogenesis Factor 26 (PEX26) which is a part of the peroxin-26 gene family is probably required for protein import into peroxisomes. PEX26 attaches PEX1 and PEX6 to peroxisome membranes to form heteromeric AAA ATPase complexes needed for the import of proteins into peroxisomes. Deficiencies in this gene are the cause of peroxisome biogenesis disorder complementation group 8. PBD is a group of peroxisomal disorders evolving from a failure of protein import into the peroxisomal membrane or matrix.

    • Synonyms

      PBD7A, PBD7B, PEX26M1T, Pex26pM1T, Peroxisome assembly protein 26, PEX26.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMKSDSST SAAPLRGLGG PLRSSEPVRA VPARAPAVDL LEEAADLLVV HLDFRAALET CERAWQSLAN HAVAEEPAGT SLEVKCSLCV VGIQALAEMD RWQEVLSWVL QYYQVPEKLP PKVLELCILL YSKMQEPGAV LDVVGAWLQD PANQNLPEYG ALAEFHVQRV LLPLGCLSEA EELVVGSAAF GEERRLDVLQ AIHTARQQQK QEHSGSEEAQ KPNLEGSVSH KFLSLPMLVR QLWDSAVSH.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Pex26 Human
  • View Data Sheet

    Description:

    Peroxisomal Biogenesis Factor 19 Human Recombinant

    Peroxisomal biogenesis factor 19, Peroxisomal farnesylated protein, HK33, 33kDa housekeeping protein, PXF, PMP1, PXMP1, Peroxin-19, D1S2223E, FLJ55296.

    Product # :

    PRO-925

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    Description

    PEX19 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 316 amino acids (1-296) and having a molecular mass of 34.6 kDa.The PEX19 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    The PEX19 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      PEX19 is vital for peroxisome biogenesis in Saccharomyces cerevisiae. PEX19 is limited to the outer surface of peroxisomes in liver cells and is has a part in the early stage of peroxisome membrane assembly, prior to the import of matrix protein.

    • Synonyms

      Peroxisomal biogenesis factor 19, Peroxisomal farnesylated protein, HK33, 33kDa housekeeping protein, PXF, PMP1, PXMP1, Peroxin-19, D1S2223E, FLJ55296.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MAAAEEGCSV GAEADRELEE LLESALDDFD KAKPSPAPPS TTTAPDASGP QKRSPGDTAK DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH LVEQFQKLSE AAGRVGSDMT SQQEFTSCLK ETLSGLAKNA TDLQNSSMSE EELTKAMEGL GMDEGDGEGN ILPIMQSIMQ NLLSKDVLYP SLKEITEKYP EWLQSHRESL PPEQFEKYQE QHSVMCKICE QFEAETPTDS ETTQKARFEM VLDLMQQLQD LGHPPKELAG EMPPGLNFDL DALNLSGPPG ASGEQC

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Pex19 Human

About PEX / Peroxisomal Biogenesis Factor protein:

The Peroxisomal Biogenesis Factor protein, PEX, is encoded by the gene PEX. This protein is a member of the peroxisome biogenesis factor family of proteins. It plays a vital role in liver development and lipid metabolism. The human PEX gene contains three exons and two introns, spans about 4 kb, and localizes to chromosome 6p22-p21.1 (6q24).

PEX Mechanism
The mechanisms by which PEX gene products take part in liver development and lipid metabolism are not precise.

Peroxisomal Biogenesis Factor Protein Structure
PEX proteins contain two domains, an amino-terminal peroxisomal targeting sequence (PTT) domain with about 275 residues long and a carboxy-terminal catalytic domain with a Rossman fold.

PEX Function
The function of this enzyme is to catalyse the formation of plasmalogens by adding a long-chain fatty acid. Octadecyl acetate (C18:0) in type I peroxisomes and C20:0 acetic acid is usually in type II peroxisomes.

Peroxisomal Biogenesis Factor Protein Interactions
PEX protein interacts with a set of proteins, including the peroxisomal membrane protein PMP22, PXMP-13, and CXXC-type zinc finger proteins. More research is needed to elucis the mechanism, structure, and function of PEX.

Importance of PEX
PEX protein plays a crucial role in lipid metabolism, and it implicates in several pathophysiological processes, including cancer, liver development, aging of the brain.

Peroxisomal Biogenesis Factor Protein Positioning
The PEX protein is in the peroxisome, a cellular organelle that plays several roles in lipid metabolism. You can find it an interactor of other proteins and transcription factors essential for liver development and lipid metabolism.