- Name
- Description
- Cat#
- Pricings
- Quantity
Catalogue number
PKA-123
Synonyms
Serine/threonine-protein kinase STK11, Liver kinase B1, LKB1, hLKB1, Renal carcinoma antigen NY-REN-19, STK11, LKB1, PJS
Introduction
STK11, which controls cell polarity and functions as a tumour suppressor, belongs to the serine/threonine kinase family. Mutations in this gene have been linked to Peutz-Jeghers syndrome- an autosomal dominant disorder. It is characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms.
Description
STK11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 456 amino acids (1-433) and having a molecular mass of 51kDa.
STK11 is fused to a 23 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
The STK11 solution (0.5mg/ml) contains 10% Glycerol and 20mM Tris-HCl buffer (pH 8.0).
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMEVVDPQ QLGMFTEGEL MSVGMDTFIH RIDSTEVIYQ PRRKRAKLIG KYLMGDLLGE GSYGKVKEVL DSETLCRRAV KILKKKKLRR IPNGEANVKK EIQLLRRLRH KNVIQLVDVL YNEEKQKMYM VMEYCVCGMQ EMLDSVPEKR FPVCQAHGYF CQLIDGLEYL HSQGIVHKDI KPGNLLLTTG GTLKISDLGV AEALHPFAAD DTCRTSQGSP AFQPPEIANG LDTFSGFKVD IWSAGVTLYN ITTGLYPFEG DNIYKLFENI GKGSYAIPGD CGPPLSDLLK GMLEYEPAKR FSIRQIRQHS WFRKKHPPAE APVPIPPSPD TKDRWRSMTV VPYLEDLHGA DEDEDLFDIE DDIIYTQDFT VPGQVPEEEA SHNGQRRGLP KAVCMNGTEA AQLSTKSRAE GRAPNPARKA CSASSKIRRL SACKQQ
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.