PLGF1 Human, HEK

PIGF, PGF, PLGF-1.

PLGF1 Human Recombinant produced in HEK293 cells is a single, glycosylated polypeptide chain (a.a 19-149) containing 137 amino acids and having a molecular mass of 15.5kDa. PLGF1 is fused to a 6 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.

HEK293 cells.

Sterile Filtered colorless solution.

PLGF1 protein (0.5mg/ml) contains Phosphate-Buffered Saline (pH 7.4) and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. 
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Greater than 90.0% as determined by SDS-PAGE. 

Measured by its binding ability in a functional ELISA with Human VEGFR1/Flt-1.

LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECRPLREKMK PERCGDAVPR RHHHHHH.

SDS

Placental growth factor 1 (PLGF1), a member of the vascular endothelial growth factor (VEGF) family, plays a pivotal role in angiogenesis and vascular development. In its human recombinant form, PLGF1 serves as a valuable tool for dissecting the molecular intricacies of angiogenic signaling and exploring its potential applications in therapeutic interventions. This research embarks on an illuminating journey to unravel the diverse roles of PLGF1 Human Recombinant, shedding light on its structural attributes, signaling pathways, and its implications in both physiological vascular development and pathological conditions such as cancer. By delving into the properties of PLGF1, scientists aim to deepen our understanding of angiogenesis and pave the way for innovative strategies in vascular-targeted therapies.

Structural Insights into PLGF1 Human Recombinant:

PLGF1, a homodimeric glycoprotein, possesses a distinctive structural configuration crucial for its interactions with VEGF receptors. The human recombinant form allows for a controlled exploration of the three-dimensional intricacies of PLGF1, providing insights into its binding affinities and conformational dynamics. Understanding its structure is fundamental for deciphering how PLGF1 orchestrates angiogenic responses in different physiological and pathological contexts.

Angiogenic Signaling Pathways:

The primary function of PLGF1 lies in its ability to induce angiogenesis by binding to VEGF receptors on endothelial cells. This interaction triggers downstream signaling pathways that promote endothelial cell proliferation, migration, and the formation of new blood vessels. Studies involving PLGF1 Human Recombinant offer a detailed exploration of these signaling cascades, unraveling the molecular events that drive angiogenesis.

Physiological Roles in Vascular Development:

PLGF1 is a key player in physiological vascular development, particularly during embryogenesis and placental formation. The controlled expression of PLGF1 is critical for orchestrating the intricate processes of vascular patterning and remodeling. Understanding the physiological roles of PLGF1 sheds light on its significance in tissue development and repair.

Implications in Pathological Angiogenesis:

While PLGF1 is essential for normal vascular development, dysregulation of its expression is associated with pathological angiogenesis. In conditions such as cancer, PLGF1 can contribute to the formation of abnormal blood vessels that support tumor growth and metastasis. Investigations involving PLGF1 Human Recombinant provide insights into the mechanisms by which PLGF1 contributes to pathological angiogenesis, offering potential targets for anti-angiogenic therapies.

Challenges and Future Directions:

While the potential of PLGF1 Human Recombinant in understanding angiogenesis is evident, challenges persist. Fine-tuning its applications, understanding its interactions with other angiogenic factors, and deciphering the context-dependent nature of its functions are critical considerations for translational success. Additionally, developing strategies to selectively target PLGF1 in pathological conditions without compromising its physiological roles poses a challenge in the pursuit of therapeutic interventions.

PLGF1 Human Recombinant stands at the forefront of angiogenesis research, offering a controlled platform for scientific exploration. Its structural insights, angiogenic signaling functions, and implications in both physiological and pathological contexts position it as a key player in the evolving landscape of vascular biology. As researchers continue to delve into the molecular intricacies of PLGF1, they not only enhance our understanding of angiogenesis but also pave the way for transformative advancements in vascular-targeted therapies, shaping the future of precision medicine and anti-angiogenic interventions.