About NCF / Neutrophil Cytosolic Factor:
Neutrophil Cytosolic Factor Protein, also referred to as NCF or p47phox is a protein found in humans which is encoded by the NCF1 gene.
NCF Mechanism
The NCF protein is part of a process that develops the NADPH oxidase enzyme that plays a vital role in the human immune system.
However, there is evidence that gene mutations can account for up to a quarter of all chronic granulomatous disease cases. This can affect the immune system, which also puts the individual at risk of recurrent infections.
Another health condition is Williams syndrome, and this is caused by an altogether absence of the NCF in chromosome 7.
Neutrophil Cytosolic Factor Interactions
Studies have shown that Neutrophil Cytosolic Factor interacts with at least three proteins. These are Moesin, Neutrophil Cytosolic Factor 4 and RELA.
NCF Function
Without the NCF protein, the body would not stimulate phagocytes or begin creating NADPH oxidase. From here, several other compounds are generated, which include hydrogen peroxide and hypochlorous acid, two ingredients that are designed to kill infections.
By playing a part in creating this, NCF will contribute to eliminating foreign invaders to the body’s immune system. This allows you to remove possible infections and bacteria before it gets the chance the latch on, duplicate and spread throughout the body.
Neutrophil Cytosolic Factor Structure
NCF is a subunit of a group of proteins that creates an enzyme complex NADPH oxidase. Overall, 358 contain orthologs with the NCF1 human gene. These organisms include Rhesus monkeys, rats, chickens, zebrafish, and frogs.
Variations of NCF are linked to several health conditions, including those listed above. Other conditions can include autoimmune disease, as the body is not capable of providing the right level of defense against infections.