MUC1 ( 47 a.a.) Human

KL-6, ADMCKD1, ADMCKD, Ca15-3, CD227.

The MUC1Human is created as a recombinant protein with a 4kda N-terminal fusion of His Tag. The MUC1His-Tagged Fusion Protein, produced in E. coli, is a 10kDa protein containing 47 amino acid residues of the MUC1Human, 1094-1140 amino acids.

Escherichia Coli.

Filtered White lyophilized (freeze-dried) powder.

Each mg was lyophilized with 1xPBS, 0.4% SDS and 4mM DTT.

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture.

Store lyophilized MUC1at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Greater than 90% as determined by SDS-PAGE.

L R P G S V V V Q L T L A F R E G T I N V H D V E T Q F N Q Y K T E A A S R Y N L T I S D V

S G

SDS

Human Mucin-1 also known as MUC1, is a glycoprotein with extensive O-linked glycosylation of its extracellular domain.

MUC1 has alpha and beta subunits that form a heterodimeric complex.

The N-terminal alpha subunit roles in cell-adhesion and the C-terminal beta subunit is involved in cell signaling.

Mucins line the apical surface of epithelial cells in the stomach, lungs, intestines, eyes and other tissues.

Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface.

Overexpression of MUC1 can be related to various cancers.