LILRA3 Human

LILRA3, ILT6, LIR4, LIR-4, LILRA3, CD85e, Leukocyte immunoglobulin-like receptor subfamily A member 3, leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 1, CD85 antigen-like family member E, Immunoglobulin-like transcript 6, Leukocyte immunoglobulin-like receptor 4, Monocyte inhibitory receptor HM43/HM31.

LILRA3 Human Recombinant is a single, glycosylated, polypeptide chain (24-439 a.a) containing a total of 658 amino acids and having a molecular mass of 72.2 kDa.
LILRA3 is fused to a 239 a.a hIgG-his-Tag at C-terminus and is purified by proprietary chromatographic techniques.

HEK293 Cells.

Sterile Filtered colorless solution.

The LILRA3 solution (0.5mg/ml) contains 10% Glycerol and Phosphate-Buffered Saline (pH 7.4).

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.  For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Greater than 95.0% as determined by SDS-PAGE.

DGSGPLPKPT LWAEPGSVIT QGSPVTLRCQ GSLETQEYHL YREKKTALWI TRIPQELVKK GQFPILSITW EHAGRYCCIY GSHTAGLSES SDPLELVVTG AYSKPTLSAL PSPVVTSGGN VTIQCDSQVA FDGFILCKEG EDEHPQCLNS HSHARGSSRA IFSVGPVSPS RRWSYRCYGY DSRAPYVWSL PSDLLGLLVP GVSKKPSLSV QPGPVVAPGE KLTFQCGSDA GYDRFVLYKE WGRDFLQRPG RQPQAGLSQA NFTLGPVSRS YGGQYTCSGA YNLSSEWSAP SDPLDILITG QIRARPFLSV RPGPTVASGE NVTLLCQSQG GMHTFLLTKE GAADSPLRLK SKRQSHKYQA EFPMSPVTSA HAGTYRCYGS LSSNPYLLTH PSDPLELVVS GAAETLSPPQ NKSDSKAGEL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH.

SDS

Leukocyte Immunoglobulin Like Receptor A3 (LILRA3) acts as a soluble receptor for class I MHC antigens.  LILRA3 binds classical and non-classical HLA class I molecules and exhibits high affinity for monocyte surfaces, effectively suppressing LPS-induced TNF-alpha production. Unlike many of its family, LILRA3 has no transmembrane domain.