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KCNMB3 Human

KCNMB3 Human

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  • KCNMB3 Human

  • KCNMB3 Human Recombinant
  • PRO-2072
  • Shipped with Ice Packs

Catalogue number

PRO-2072

Synonyms

Potassium Channel Subfamily M Regulatory Beta Subunit 3, Potassium Large Conductance Calcium-Activated Channel, Subfamily M Beta Member 3, Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-3, Charybdotoxin Receptor Subunit Beta-3, Big Potassium Channel Beta Subunit 3, Maxi K Channel Subunit Beta-3, MaxiK Channel Beta-Subunit 3, BK Channel Beta Subunit 3, BK Channel Subunit Beta-3, K(VCA)BETA-3, SLO-BETA-3, BKBETA3, Hbeta3, KCNMB2, KCNMBL, Large Conductance, Voltage And Ca2+ Activated Potassium Channel Maxi K Beta 3 Subunit, Calcium-Activated Potassium Channel Regulatory Subunit, SLOBETA3, Calcium-activated potassium channel subunit beta-3.

Introduction

The KCNMB3 belongs to a family of 4 auxiliary beta subunits found in the mammalian genome, which associate with Slo1 alpha subunits and regulate BK channel function. In humans, the KCNMB3 gene is comprised of 4 N-terminal alternative exons which produce 4 functionally distinct beta3 subunits, beta3a-d. Three variants, beta3a-c, display kinetically distinct inactivation behaviors.

Description

KCNMB3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 149 amino acids (82-207 a.a) and having a molecular mass of 16.8kDa.
KCNMB3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

KCNMB3 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Purity

Greater than 85.0% as determined by SDS-PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSKPFMLSI QREESTCTAI HTDIMDDWLD CAFTCGVHCH GQGKYPCLQV FVNLSHPGQK ALLHYNEEAV QINPKCFYTP KCHQDRNDLL NSALDIKEFF DHKNGTPFSC FYSPASQSED VILIKKYDQ.

Safety Data Sheet

SDS

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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