DNA-Damage Protein

About DNA-Damage Protein:

DNA damage proteins are collectively known as the DNA damage response, otherwise shortened to DDR. They are sophisticated cellular networks that continually monitor genome integrity.

DNA-Damage Protein Mechanism
One of the most common features of DNA damage response proteins is how they mobilize as a response to genotoxic stress. A number of complementary methodologies have developed that have supplied us with key insights with regard to the spatiotemporal dynamics of DDR protein assembly and disassembly at DNA strand break sites within eukaryotic cells.
A number of important advancements have also been made with regard to our comprehension of the molecular mechanisms that underpin these events. Significant advances have also been made when it comes to our comprehension of the molecular mechanisms that underlie these events, as post-translation modifications of DDR factors have been shown to play a critical role when it comes to the controlling of foci formation in response to DNA-damaging agents.

DNA-Damage Protein Function
DNA DSBs represent the most deleterious type of DNA damage, as they will not leave a complementary strand intact that could be utilized as a DNA repair template. If this is not repaired, they can end up resulting in translocations and chromosome breaks that have been linked with the likes of cancer predisposition, sterility, radiosensitivity, immunodeficiency, neurodegeneration, and developmental defects.