About ELP / Elongator Acetyltransferase Complex:
Elongator Acetyltransferase Complex, also known as ELP, associates with RNA polymerase II during transcriptional elongation. It’s a 6-subunit histone acetyltransferase that’s linked with ELP2, which functions as a core subunit of the complex.
The ELP2 was identified in 2002 by Hawkes et al., who discovered it through the mass spectrometric analysis method of looking at proteins that were purified with the elongator complex.
ELP Structure
Structurally, it has eight putative WD40 repeats and a C-terminal region. Homologically speaking, it connects with the signature-2 motif of RCC1. The mass of ELP2 is 95 kD by SDS-PAGE.
Elongator Acetyltransferase Complex Function
The elongator complex will copurify with ELP2 from HeLa cells. There are two forms of elongator complex; the holo-elongator and a 3-subunit core form. The first has a histone acetyltransferase that is active against histones H3 and H4. The second does not have histone acetyltransferase activity, even though it contains ELP3, a catalytic subunit. ELP2 and IKAP are also present in the core elongator complex, while ELP4, ELP5, and ELP6 were found in the active holo-elongator complex.
ELP Sequence
The ELP2 gene is mapped to 18q12.2, a chromosome. This is based on an alignment of the sequence of ELP2 with the genomic sequence. Looking at it from a lens of molecular genetics, we should look at it through a study of homozygosity mapping, which was conducted on 136 consanguineous families with segregating syndromic or nonsyndromic forms of autosomal recessive intellectual disability. A homozygous missense mutation of the ELP2 gene was identified in two families. The mutations segregated with the disorder in the family.