{"title":"Vascular cell adhesion molecule","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout VCAM \/ Vascular Cell Adhesion Molecule:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe vascular cell adhesion molecule is a protein, and it is encoded in humans by a gene known as VCAM1. This functions as a cell adhesion molecule, and proves to be an extremely important process in many forms of life and physiological systems around the world.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eVCAM Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eLooking at the structure of the VCAM-1 gene, we can see six or seven immunoglobulin domains, and the expression on both large and small blood vessels, however this is only after the endothelial cells have been stimulated by cytokines. The molecule is alternatively spliced into two known RNA transcripts, and these transcripts are known to encode different isoforms in humans. The gene product is called a cell surface sialoglycoprotein, which is a type I membrane protein.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eVascular Cell Adhesion Molecule Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe primary function of the vascular cell adhesion molecule is to mediate the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. At the same time, the molecule is known to function in leukocyte-endothelial cell signal transduction. There is also a chance, although it is as yet unproven, that it may play a role in the development of atherosclerosis and therefore rheumatoid arthritis.\u003cbr data-mce-fragment=\"1\"\u003eSimilarly, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of integrins. This type of expression, which we would call VCAM-1 expression, is also known to occur in other cell types such as smooth muscle cells. It has also been shown to interact with EZR and Moesin, and it could exist on the surface of some subpopulations of mesenchymal stem cells (MSC).\u003c\/p\u003e","products":[{"product_id":"vcam1-human","title":"VCAM1 Human","description":"\u003cp\u003eVascular Cell Adhesion Molecule 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eVascular cell adhesion protein 1, V-CAM 1, INCAM-100, CD106, VCAM1, L1CAM, MGC99561, DKFZp779G2333.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175111163988,"sku":"PRO-386","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175111196756,"sku":"PRO-386","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175111229524,"sku":"PRO-386","price":3200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-vcam1-human-PRO-386.png?v=1776714312"},{"product_id":"vcam1-human-hek","title":"VCAM1 Human, HEK","description":"\u003cp\u003eVascular cell adhesion molecule 1 Human Recombinant, HEK\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eVascular cell adhesion protein 1, V-CAM 1, INCAM-100, CD106, VCAM1, L1CAM, MGC99561, DKFZp779G2333.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43175112179796,"sku":"PRO-1641","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43175112212564,"sku":"PRO-1641","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175112245332,"sku":"PRO-1641","price":1900.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-vcam1-human-hek-PRO-1641.png?v=1776714307"},{"product_id":"vcam1-human-sf9","title":"VCAM1 Human, sf9","description":"\u003cp\u003eVascular cell adhesion molecule 1 Human Recombinant, sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eVascular Cell Adhesion Molecule 1, CD106 Antigen,\nINCAM-100 , Vascular Cell Adhesion Protein 1, V-CAM 1, VCAM-1, CD106, L1CAM.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175113097300,"sku":"PRO-2367","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175113130068,"sku":"PRO-2367","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175113162836,"sku":"PRO-2367","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-vcam1-human-sf9-PRO-2367.png?v=1776714315"},{"product_id":"vcam1-mouse","title":"VCAM1 Mouse","description":"\u003cp\u003eVascular cell adhesion molecule 1 Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eV-CAM\n1, VCAM-1, CD106, Vcam1, Vcam-1, Vascular cell adhesion protein 1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175114440788,"sku":"PRO-2257","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175114473556,"sku":"PRO-2257","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175114506324,"sku":"PRO-2257","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-vcam1-mouse-PRO-2257.png?v=1776714320"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_f65adaaa-4962-424e-b998-d236a4ed36f1.png?v=1700648077","url":"https:\/\/prospecbio.com\/collections\/vascular-cell-adhesion-molecule.oembed","provider":"prospecbio","version":"1.0","type":"link"}