{"title":"UCHL1","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout UCHL1:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eUbiquitin C-terminal hydrolase L1 is a very plentiful protein found in the brain. It is estimated to make up 1 to 5 percent of the total neuron protein. The mutation and anomalous functions of this enzyme have been linked to numerous neurological disorders. This protein plays a significant role in the repair of axons and neurons after injury by getting rid of any unusual proteins by the Ubiquitin-proteasomes pathway and autophagy.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eUCHL1 Functions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eUbiquitin C-terminal hydrolase L1 is an essential element for neuronal development mechanisms. It has an inhibitory impact on complexes containing mTOR, hence regulating the degeneration and synthesis of protein.\u003cbr data-mce-fragment=\"1\"\u003eThe composition of this enzyme is significant and specific to cells and neurons of the diffuse neuroendocrine system and their neoplasms. The catalytic triad of this protein is made of a cysteine at the point of 90, an aspartate at 176 and a histidine at 161. This catalytic triad is all accountable for its hydrolase activity.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eUCHL1 Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eUCHL1 belongs to the peptidase C12 family. The protein has one of the most compound knot structures and a five-knot crossing created for protein. The knotted structure is said to enhance the protein's resistance to degeneration in the proteasome. This is also a good indication of neuroprotection or diagnostics.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eUCHL1 Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eUbiquitin C-terminal hydrolase L1 has been identified to display interactions with a-synuclein, a protein linked in the pathology of Parkinson's disease. It has also been shown to have an interaction with constitute photomorphogenic homolog subunit (COP9).\u003cbr data-mce-fragment=\"1\"\u003eBesides, this enzyme has most recently been identified to interact with parkin, the E3 ligase. Parkin has been found to bind and ubiquitinylate the Ubiquitin C-terminal hydrolase L1 to enhance the lysosomal degradation of the enzyme.\u003c\/p\u003e","products":[{"product_id":"uchl1-protein","title":"UCHL1 (1-126) Human","description":"\u003cp\u003eUbiquitin Carboxyl-Terminal Hydrolase L1 (1-126) Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003ePGP 9.5, UCHL1, PGP9.5, PARK5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"50µg","offer_id":43175024459860,"sku":"PRO-2823","price":200.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43175024492628,"sku":"PRO-2823","price":300.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175024525396,"sku":"PRO-2823","price":1500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-uchl1-protein-PRO-2823.png?v=1776713953"},{"product_id":"uchl1-human","title":"UCHL1 Human","description":"\u003cp\u003eUbiquitin Carboxyl-Terminal Hydrolase L1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eUbiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175026262100,"sku":"PRO-576","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43175026294868,"sku":"PRO-576","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175026327636,"sku":"PRO-576","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-uchl1-human-PRO-576.png?v=1776713944"},{"product_id":"uchl1-mouse","title":"UCHL1 Mouse","description":"\u003cp\u003eUbiquitin Carboxyl-Terminal Esterase L1 Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eUbiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1,\nNeuron cytoplasmic protein 9.5, PGP 9.5, PGP9.5, Ubiquitin thioesterase L1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175028293716,"sku":"PRO-2235","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175028326484,"sku":"PRO-2235","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175028359252,"sku":"PRO-2235","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-uchl1-mouse-PRO-2235.png?v=1776713947"},{"product_id":"uchl-1-mouse","title":"UCHL1 Mouse, Active","description":"\u003cp\u003eUbiquitin Carboxyl-Terminal Esterase L1 Mouse Recombinant, Active\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eUbiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1,\nNeuron cytoplasmic protein 9.5, PGP 9.5, PGP9.5, Ubiquitin thioesterase L1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175029112916,"sku":"PRO-2424","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175029145684,"sku":"PRO-2424","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175029178452,"sku":"PRO-2424","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-uchl-1-mouse-PRO-2424.png?v=1776713935"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_0ea152ac-66f3-47a2-bdfc-f51105ea4d0f.png?v=1700648069","url":"https:\/\/prospecbio.com\/collections\/uchl1.oembed","provider":"prospecbio","version":"1.0","type":"link"}