{"title":"U6 Small Nuclear RNA","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout LSM \/ U6 Small Nuclear RNA:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSmall Nuclear RNA is a category of Small RNA molecules located within the splicing speckles and the Cajal bodies of the cell nucleus in all eukaryotic animals. On the other hand, the U6 Small Nuclear RNA is the nucleolar snRNA element of small nuclear ribonucleoprotein. The U6 snRNA, also known as LSM, is an RNA- Protein compound that combines with other small nuclear ribonucleoproteins, unmodified precursor messenger RNA, also known as pre-mRNA, plus other proteins to gather a spliceosome. A spliceosome is a big RNA- protein molecular compound that plays a significant role in catalyzing the excision of introns from pre-mRNA.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eLSM Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe U6 small nuclear RNA is made of many protein elements. And apart from that, this spliceosome has five uridine-rich small nuclear RNA that go through an elaborate series of conformational transitions to accurately identify the splice sites and catalyze intron removal.\u003cbr data-mce-fragment=\"1\"\u003eIn the mammalian cells, there are six main molecular species that are filled with proteins, creating small nuclear ribonucleoprotein molecules in precursor messenger RNA splicing as part of the spliceosome.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eU6 Small Nuclear RNA Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eAccording to many years of genetic and biochemical data, this protein forms most of the catalytic core of the spliceosome and is highly dynamic. It interacts with three small nuclear RNAs, namely the precursor messenger RNA substrate and more than twenty-five more protein partners during the splicing cycle.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eLSM Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe U6 small nuclear RNA is vital for and might participate in the catalysis of precursor messenger RNA splicing. Some nucleotides needed for U6 function and spicing have been identified in numerous mutation analyses in many systems.\u003c\/p\u003e","products":[{"product_id":"lsm1-human","title":"LSM1 Human","description":"\u003cp\u003eLSM1 Homolog, U6 Small Nuclear RNA Associated Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eU6 snRNA-associated Sm-like protein LSm1, Cancer-associated Sm-like, Small nuclear ribonuclear CaSm, LSM1, CASM, YJL124C.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175018987604,"sku":"PRO-259","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175019020372,"sku":"PRO-259","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175019053140,"sku":"PRO-259","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lsm1-human-PRO-259.png?v=1776701749"},{"product_id":"lsm12-human","title":"LSM12 Human","description":"\u003cp\u003eLSM12 Homolog, U6 Small Nuclear RNA Associated Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003ePNAS-135, Protein LSM12 homolog, LSM12.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175019937876,"sku":"PRO-1329","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175019970644,"sku":"PRO-1329","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43175020003412,"sku":"PRO-1329","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lsm12-human-PRO-1329.png?v=1776701753"},{"product_id":"lsm2-human","title":"LSM2 Human","description":"\u003cp\u003eLSM2 Homolog, U6 Small Nuclear RNA Associated Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLSM2 homolog U6 small nuclear RNA associated (S. cerevisiae), Small nuclear ribonuclear protein D homolog, chromosome 6 open reading frame 28, snRNP core Sm-like protein Sm-x5, C6orf28, YBL026W, Protein G7b, snRNP.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175021510740,"sku":"PRO-1069","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175021543508,"sku":"PRO-1069","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175021576276,"sku":"PRO-1069","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lsm2-human-PRO-1069.png?v=1776701762"},{"product_id":"lsm3-human","title":"LSM3 Human","description":"\u003cp\u003eLSM3 Homolog, U6 Small Nuclear RNA Associated Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLSM3 homolog U6 small nuclear RNA associated (S. cerevisiae), U6 snRNA-associated Sm-like protein LSm3, SMX4, USS2, YLR438C.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175022198868,"sku":"PRO-1060","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175022231636,"sku":"PRO-1060","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175022264404,"sku":"PRO-1060","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lsm3-human-PRO-1060.png?v=1776701766"},{"product_id":"lsm4-human","title":"LSM4 Human","description":"\u003cp\u003eLSM4 Homolog, U6 Small Nuclear RNA Associated Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eU6 snRNA-associated Sm-like protein LSm4, Glycine-rich protein, GRP, LSM4, YER112W.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175023181908,"sku":"PRO-065","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175023214676,"sku":"PRO-065","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175023247444,"sku":"PRO-065","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lsm4-human-PRO-065.png?v=1776701770"},{"product_id":"lsm5-human","title":"LSM5 Human","description":"\u003cp\u003eLSM5 Homolog, U6 Small Nuclear RNA Associated Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLSM5 homolog, U6 small nuclear RNA associated\n(S.cerevisiae), YER146W, U6 snRNA-associated Sm-like protein LSm5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175024951380,"sku":"PRO-795","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175024984148,"sku":"PRO-795","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175025016916,"sku":"PRO-795","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lsm5-human-PRO-795.png?v=1776701778"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_e9a982a3-848f-4c1f-8616-09d4ff627a6a.png?v=1700647617","url":"https:\/\/prospecbio.com\/collections\/u6-small-nuclear-rna.oembed","provider":"prospecbio","version":"1.0","type":"link"}