{"title":"TROVE Domain Family","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout TROVE2 \/ TROVE Domain Family:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe TROVE domain family is mainly found in the TEP1 and Ro60, protein components of ribonucleoproteins.\u003cbr data-mce-fragment=\"1\"\u003eThe TROVE domain family is a module of residues found in protein components (TEP1 and Ro60) of ribonucleoprotein particles. The TROVE domain family is also present in the ribonucleoprotein of bacteria. Additionally, it is associated with other domain families, such as the TEP1 N-terminal, VWFA, WD-40, and NACHT-NTPase domains.\u003cbr data-mce-fragment=\"1\"\u003eThe TROVE domain family is involved in binding three RNA components (Y RNA, telomerase RNA, and vault RNA). The TROVE domain family is made up of some absolute conserved residues, though there is little evidence to prove that they have enzymatic functions.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTROVE2 Characteristics\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe Ro60 human recombinant is a single, non-glycosylated polypeptide chain with a molecular mass of 60kDa. It is produced in the E. Coli.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTROVE Domain Family Functions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe TROVE domain family (TROVE2) is mainly involved in RNA binding. The second conserved area of the proteins is a component in the vWA domain family. The vWA domain in TEP1is found to be closely related to the vWA domain found in VPARP. The vWA domain induces interaction between vaults and may also bind as an unrecognized RNP component.\u003cbr data-mce-fragment=\"1\"\u003eTROVE2 binds several cytoplasmic RNA particles and stabilizes them from degradation. In patients with SLE, the proteins react with normal cellular SSA2 proteins.\u003cbr data-mce-fragment=\"1\"\u003eRibonucleoprotein components rely on a regular RNA binding module, the TROVE module. This module is found in bacterial ribonucleoproteins, which suggest that they have an ancient origin.\u003c\/p\u003e","products":[{"product_id":"trove2-bovine","title":"TROVE2 Bovine","description":"\u003cp\u003eTROVE Domain Family, Member 2, Bovine\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003e60 kDa SS-A\/Ro ribonucleoprotein, 60 kDa ribonucleoprotein Ro, RoRNP, 60 kDa Ro protein, Ro 60 kDa autoantigen, TROVE domain family member 2, Sjoegren syndrome type A antigen, SS-A, Sjoegren syndrome antigen A2, TROVE2, RO60, SSA2, RO-60.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174906986580,"sku":"PRO-111","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174907019348,"sku":"PRO-111","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174907052116,"sku":"PRO-111","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-trove2-bovine-PRO-111.png?v=1776713360"},{"product_id":"ro60-bovine","title":"TROVE2 Bovine, Biotin","description":"\u003cp\u003eTROVE Domain Family Member 2 Human Recombinant, Biotinlyated\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003e60 kDa SS-A\/Ro ribonucleoprotein, 60 kDa ribonucleoprotein Ro, RoRNP, 60 kDa Ro protein, Ro 60 kDa autoantigen, TROVE domain family member 2, Sjoegren syndrome type A antigen, SS-A, Sjoegren syndrome antigen A2, TROVE2, RO60, SSA2, RO-60.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"50µg","offer_id":43174908362836,"sku":"PRO-2561","price":600.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174908395604,"sku":"PRO-2561","price":900.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174908428372,"sku":"PRO-2561","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-ro60-bovine-PRO-2561.png?v=1776709735"},{"product_id":"trove2-his-human","title":"TROVE2 His Human","description":"\u003cp\u003eTROVE Domain Family Member 2 His Tag Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003e60 kDa SS-A\/Ro ribonucleoprotein, 60 kDa ribonucleoprotein Ro, RoRNP, 60 kDa Ro protein, Ro 60 kDa autoantigen, TROVE domain family member 2, Sjoegren syndrome type A antigen, SS-A, Sjoegren syndrome antigen A2, TROVE2, RO60, SSA2, RO-60.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174909280340,"sku":"PRO-110","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174909313108,"sku":"PRO-110","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174909345876,"sku":"PRO-110","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-trove2-his-human-PRO-110.png?v=1776713366"},{"product_id":"trove2-human","title":"TROVE2 Human","description":"\u003cp\u003eTROVE Domain Family Member 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003e60 kDa SS-A\/Ro ribonucleoprotein, 60 kDa ribonucleoprotein Ro, RoRNP, 60 kDa Ro protein, Ro 60 kDa autoantigen, TROVE domain family member 2, Sjoegren syndrome type A antigen, SS-A, Sjoegren syndrome antigen A2, TROVE2, RO60, SSA2, RO-60.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43174910165076,"sku":"PRO-329","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174910197844,"sku":"PRO-329","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174910230612,"sku":"PRO-329","price":1350.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-trove2-human-PRO-329.png?v=1776713371"},{"product_id":"ro60-human","title":"TROVE2 Human, His Biotin","description":"\u003cp\u003eTROVE Domain Family Member 2 Human Recombinant, His Tag Biotinylated\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003e60 kDa SS-A\/Ro ribonucleoprotein, 60 kDa ribonucleoprotein Ro, RoRNP, 60 kDa Ro protein, Ro 60 kDa autoantigen, TROVE domain family member 2, Sjoegren syndrome type A antigen, SS-A, Sjoegren syndrome antigen A2, TROVE2, RO60, SSA2, RO-60.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"50µg","offer_id":43174910984276,"sku":"PRO-2560","price":600.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174911017044,"sku":"PRO-2560","price":900.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174911049812,"sku":"PRO-2560","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-ro60-human-PRO-2560.png?v=1776709739"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_40596446-91ab-45ad-800d-6d556b17efae.png?v=1700648058","url":"https:\/\/prospecbio.com\/collections\/trove-domain-family.oembed","provider":"prospecbio","version":"1.0","type":"link"}