{"title":"Tripartite Motif","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout TRIM \/ Tripartite Motif:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eTRIM proteins are heterodimeric, with two distinct subunits; RING domain and B-box 1 or 2. TRIM was discovered in 1993 by researchers looking for proteins that interact with the vacuolar H+ ATPase (V-ATPase) and bind ubiquitin. TRIM-containing protein heterodimers are characterized by TRIM (Tripartite Motif) domains, consisting of an N-terminal RING domain, B-box 1, and B-box 2 motifs that form a contiguous structure with the RING motif in the central region.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTRIM Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eTRIM proteins play critical roles as E3 ubiquitin-protein ligases involved in the ubiquitination and proteolysis of target proteins. TRIM was later found to mediate TRIM5α induced restriction of HIV-1, TRIM22 caused degradation of Smoothened receptor (SMO), TRIM25 mediated degradation of activated STAT1, TRIM21 mediated degradation of Cdc25C, and TRIM15 mediated degradation of MLL2.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTripartite Motif Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eTRIM5α is a retrovirus restriction factor that functions as an intracellular \"spike\" protein expressed in the cytosol of cells following infection by the HIV-1 virus. TRIM5α specifically targets and restricts the development of HIV-1 by inducing a post-transcriptional gene silencing (PTGS) process. TRIM5α determines the virus by targeting viral capsid (CA) protein, and TRIM22 is an essential component of TRIF-dependent signaling that plays a minor role in antiviral defense by inducing the degradation of activated STAT1. TRIM22 is essential in TRIF-dependent signaling and a not so important TRIM in antiviral defense. TRIM25, TRIM21, and TRIM15 are E3 ubiquitin ligases that promote degradation of their substrates via the ubiquitin-26S proteasome system.\u003cbr data-mce-fragment=\"1\"\u003eTRIM21 regulates Cdc25C ubiquitination during the metaphase to anaphase transition. TRIM15 regulates MLL2 stability, which is essential in Hox gene cluster transcription regulation and leukemia treatment. TRIM proteins play critical roles as E3 ubiquitin-protein ligases involved in the ubiquitination and degradation of target proteins.\u003c\/p\u003e","products":[{"product_id":"trim21-human","title":"TRIM21 Human","description":"\u003cp\u003eTripartite Motif Containing 21 (RO52) Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003e52 kDa Ro protein, Sjoegren syndrome type A antigen, SS-A, Ro(SS-A), 52 kDa ribonucleoprotein autoantigen Ro\/SS-A, Tripartite motif-containing protein 21, RING finger protein 81, TRIM21, RNF81, RO52, SSA1, SSA, RO-52.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174894862420,"sku":"PRO-328","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174894895188,"sku":"PRO-328","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174894927956,"sku":"PRO-328","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-trim21-human-PRO-328.png?v=1776713295"},{"product_id":"ro52-human","title":"TRIM21 Human Biotin","description":"\u003cp\u003eTripartite Motif Containing 21 (RO52) Human Recombinant, Biotinylated\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003e52 kDa Ro protein, Sjoegren syndrome type A antigen, SS-A, Ro(SS-A), 52 kDa ribonucleoprotein autoantigen Ro\/SS-A, Tripartite motif-containing protein 21, RING finger protein 81, TRIM21, RNF81, RO52, SSA1, SSA, RO-52.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"50µg","offer_id":43174895779924,"sku":"PRO-2559","price":600.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174895812692,"sku":"PRO-2559","price":900.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174895845460,"sku":"PRO-2559","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-ro52-human-PRO-2559.png?v=1776709730"},{"product_id":"trim28-human","title":"TRIM28 Human","description":"\u003cp\u003eTripartite Motif Containing 28 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eTranscription intermediary factor 1-beta, TIF1-beta, E3 SUMO-protein ligase TRIM28, KRAB-associated protein 1, KAP-1, KRAB-interacting protein 1, KRIP-1, Nuclear corepressor KAP-1, RING finger protein 96, Tripartite motif-containing protein 28, TRIM28, KAP1, RNF96, TIF1B, Tripartite motif containing 28, RNF96, TF1B.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174896631892,"sku":"PRO-1697","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174896664660,"sku":"PRO-1697","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174896697428,"sku":"PRO-1697","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-trim28-human-PRO-1697.png?v=1776713300"},{"product_id":"trim33-human","title":"TRIM33 Human","description":"\u003cp\u003eTripartite Motif Containing 33 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eE3 ubiquitin-protein ligase TRIM33, Ectodermin homolog, RET-fused gene 7 protein, Protein Rfg7, Transcription intermediary factor 1-gamma, TIF1-gamma, Tripartite motif-containing protein 33, TRIM33, KIAA1113, RFG7, TIF1G, ECTO, PTC7, TF1G, TIFGAMMA, TIF1GAMMA.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174897647700,"sku":"PRO-1506","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174897680468,"sku":"PRO-1506","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174897713236,"sku":"PRO-1506","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-trim33-human-PRO-1506.png?v=1776713305"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_094ed423-0c05-4599-9818-aa38b94cd290.png?v=1700648056","url":"https:\/\/prospecbio.com\/collections\/tripartite-motif.oembed","provider":"prospecbio","version":"1.0","type":"link"}