{"title":"Toll Like Receptor","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout TLR \/ Toll Like Receptor:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eToll-like receptors, also known as TLRs are a class of proteins that function as part of the innate immune system. These single-pass membrane-spanning receptors are usually expressed on sentinel cells like macrophages and dendritic cells and include the family members TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13, though the last three are not found in humans.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTLR Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eToll-like receptors usually play the role of acting as a receptor for molecules that are largely shared by pathogens, which allows the immune system to recognize them. These receptors are often expressed on the membranes of leukocytes including dendritic cells, macrophages, natural killer cells, cells of the adaptive immunity T cells, and B cells, and non-immune cells (epithelial and endothelial cells, and fibroblasts).\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eToll Like Receptor Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe specific mechanisms of the TLR proteins differ from each member of the family and not all of the mechanisms are widely understood. For instance, the mechanism of TLR1 is that it recognizes peptidoglycan and (triacyl) lipopeptides in concert with TLR2 (as a heterodimer), and it mediates the production of cytokines essential for the development of effective immunity.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTLR Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe interactions of TLRs differ from each example, but they all tend to interact with a respective PAMP or DAMP as a homo- or heterodimer along with a co-receptor or accessory molecule. For instance, TLR1 interacts with TLR2, LPHN1, LPHN2, LPHN3, and DHX36\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eToll Like Receptor Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eHuman TLRs are all 700–1100 amino acids long and consist of extracellular, transmembrane, and cytoplasmic domains. The extracellular domain houses the ligand-binding site, and TLRs generally function as homodimers.\u003c\/p\u003e","products":[{"product_id":"tlr3-human","title":"TLR3 Human","description":"\u003cp\u003eToll Like Receptor 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eToll Like Receptor 3, Toll-Like Receptor 3, CD283 Antigen, CD283, IIAE2, Toll-like receptor 3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174728597588,"sku":"PRO-2511","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174728630356,"sku":"PRO-2511","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174728663124,"sku":"PRO-2511","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-tlr3-human-PRO-2511.png?v=1776712500"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_332417ff-470f-4b52-bfa1-31519f922d65.png?v=1700648047","url":"https:\/\/prospecbio.com\/collections\/toll-like-receptor.oembed","provider":"prospecbio","version":"1.0","type":"link"}