{"title":"Tissue Factor Pathway Inhibitor","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout TFPI \/ Tissue Factor Pathway Inhibitor:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eTissue factor pathway inhibitor, also known as TFPI, is a single-chain polypeptide that can inhibit Factor Xa, which allows the Xa-TFPI complex to inhibit the FVIIa-tissue factor complex. It’s located on chromosome 2q31-q32.1 and has nine exons which span 70 kb. TFPI is present in human plasma in three forms: as an LDL\/VLDL-associated form, an HDL-associated form and a free form.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTFPI Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eAs a protease inhibitor with three Kunitz-type inhibitory domains, TFPI inhibits coagulation factor Xa through the K2 domain and factor VIIa-tissue factor complex through the K1 domain. In this way, TFPI blocks the first steps of the extrinsic coagulation pathway.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTissue Factor Pathway Inhibitor Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eTFPI has been found to block early events in blood coagulation through two distinct mechanisms. The first is the inhibition of TF–factor VIIa by Kunitz domains 1 and 2, which is mediated by TFPIβ on the endothelium. The second is the inhibition of early forms of prothrombinase by Kunitz domain 2 and the C-terminal region of TFPIα released from within platelets.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTFPI Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eTFPI interacts with the proteins SON (SON DNA And RNA Binding Protein), SRSF7 (Serine and Arginine Rich Splicing Factor 7), SRSF11 (Serine and Arginine Rich Splicing Factor 11), SAP18 (Sin3A Associated Protein 18), and SMU1 (SMU1 DNA Replication Regulator and Spliceosomal Factor). It has also been shown to interact with Factor X, an enzyme of the coagulation cascade.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTissue Factor Pathway Inhibitor Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eTFPI has nine exons that span 70 kb and has a relative molecular mass of 34,000 to 40,000 depending on the degree of proteolysis of the C-terminal region. It’s made up of a negatively charged amino-terminus, three Kunitz domains, and a highly positively charged carboxy-terminus.\u003c\/p\u003e","products":[{"product_id":"tfpi-human","title":"TFPI Human","description":"\u003cp\u003eTissue Factor Pathway Inhibitor Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eTissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor), Extrinsic Pathway Inhibitor, Tissue Factor Pathway Inhibitor, anti-convertin, TFPI1, EPI, LACI, TFI.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174624198740,"sku":"PRO-1702","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174624231508,"sku":"PRO-1702","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174624264276,"sku":"PRO-1702","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-tfpi-human-PRO-1702.png?v=1776711913"},{"product_id":"tfpi-protein","title":"TFPI Human, Sf9","description":"\u003cp\u003eTissue Factor Pathway Inhibitor Human Recombinant, Sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eTissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor), Extrinsic Pathway Inhibitor, Tissue Factor Pathway Inhibitor, anti-convertin, TFPI1, EPI, LACI, TFI.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174625214548,"sku":"PRO-2441","price":50.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174625247316,"sku":"PRO-2441","price":130.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174625280084,"sku":"PRO-2441","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-tfpi-protein-PRO-2441.png?v=1776711917"},{"product_id":"tfpi2-human","title":"TFPI2 Human","description":"\u003cp\u003eTissue Factor Pathway Inhibitor 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eTissue Factor Pathway Inhibitor 2, Placental Protein 5, TFPI-2, PP5, Retinal Pigment Epithelium Cell Factor 1, REF1, TFPI2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174626164820,"sku":"PRO-860","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174626197588,"sku":"PRO-860","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174626230356,"sku":"PRO-860","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-tfpi2-human-PRO-860.png?v=1776711921"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_41991b65-545d-4425-b7b8-ee6d033b7292.png?v=1700648032","url":"https:\/\/prospecbio.com\/collections\/tissue-factor-pathway-inhibitor.oembed","provider":"prospecbio","version":"1.0","type":"link"}