{"title":"TIGAR","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout TIGAR:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eTIGAR is a newly discovered enzyme that largely regulates glucose breakdown in human cells. In addition to its role in controlling glucose degradation, TIGAR activity can allow a cell to repair DNA and degrade its own organelles. Finally, TIGAR has the ability to shield a cell from death. Since its discovery in 2005 by Kuang-Yu Jen and Vivian G. Cheung, TIGAR has piqued the scientific community's interest due to its active role in various malignancies. The p53 tumor suppressor protein normally activates TIGAR production in the body when a cell has suffered low DNA damage or stress. TIGAR is under the control of other proteins in some malignancies. The goal is that future studies into TIGAR will lead to new cancer treatments.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTIGAR Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eTIGAR has a tertiary structure similar to the histidine phosphatase fold and is approximately 30kDa. The core of TIGAR is a — sandwich composed of a six-stranded sheet encircled by four helices. To complete the enzyme, more helices and a lengthy loop are added around the core. TIGAR has a structurally similar active site to PhoE (a bacterial phosphatase enzyme) and a functionally similar active site to fructose-2,6-bisphosphatase.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTIGAR Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eTIGAR activation can have a variety of biological impacts. TIGAR works as a direct regulator of fructose-2,6-bisphosphate levels and hexokinase 2 activity, resulting in a cascade of metabolic reactions within the cell. TIGAR is a fructose bisphosphatase that activates p53, limiting glucose transporter expression and controlling the expression of hexokinase and phosphoglycerate mutase. TIGAR also inhibits Phosphofructokinase (PFK) by lowering the amount of fructose-2,6, bisphosphate, which inhibits glycolysis and promotes the pentose phosphate pathway.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e \u003c\/p\u003e","products":[{"product_id":"tigar-human","title":"C12ORF5 Human","description":"\u003cp\u003eChromosome 12 Open Reading Frame 5 Human\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eFructose-2,6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator, TIGAR, C12orf5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174535594068,"sku":"PRO-1791","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174535626836,"sku":"PRO-1791","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174535659604,"sku":"PRO-1791","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-tigar-human-PRO-1791.png?v=1776712355"},{"product_id":"c12orf5-human","title":"C12ORF5 Human, His","description":"\u003cp\u003eChromosome 12 Open Reading Frame 5 Human Recombinant, His Tag\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProbable fructose-2,6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator, TIGAR, C12orf5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174536544340,"sku":"PRO-051","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174536577108,"sku":"PRO-051","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174536609876,"sku":"PRO-051","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-c12orf5-human-PRO-051.png?v=1776678455"},{"product_id":"tigar-human-tat","title":"C12ORF5 Human, TAT","description":"\u003cp\u003eChromosome 12 Open Reading Frame 5 Human-TAT\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eFructose-2,6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator, TIGAR, C12orf5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174537396308,"sku":"PRO-1580","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174537429076,"sku":"PRO-1580","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174537461844,"sku":"PRO-1580","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-tigar-human-tat-PRO-1580.png?v=1776712360"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_f397c6ed-ead8-4f04-bffb-8527d876ac41.png?v=1700646453","url":"https:\/\/prospecbio.com\/collections\/tigar.oembed","provider":"prospecbio","version":"1.0","type":"link"}