{"title":"TGFBR","description":"\u003ch3 class=\"highlited\"\u003e\u003cspan\u003eAbout TGFBR \/ TGFB Receptor:\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003eTGFBR or transforming growth factor beta receptors belong to the TGF beta receptor family. They exist in a variety of forms and have more ligands than receptors, suggesting that there are multiple ligand-receptor interactions.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTGFBR Function\u003c\/strong\u003e\u003cbr\u003eThe purpose of TGFBR is to stimulate the body to grow new tissues. It is found all over the body, including in bone, liver, brain, heart, kidneys, and testes. Researchers also believe that it is a signaling molecule too. There is evidence that it acts as a cytokine for the pancreas, sending signals to the rest of the body for how much energy is available in the bloodstream.\u003cbr\u003eWhile TGFBR is beneficial in small quantities (like most growth factors), it can be damaging when administered in high doses. Research suggests, for instance, that high levels of TGF factor beta can induce fibrosis of the kidneys and pancreas, leading to both kidney disease and diabetes.\u003cbr\u003eRecently, researchers and drug companies have been investigating ways to manipulate TGBR to address these diseases. The idea at present is to use TGFBR antagonists to reduce levels of the enzyme in tissues throughout the body, counteracting some of the adverse effects induced by excessively high levels. Experiments to date suggest that there may be a way to reverse renal fibrosis and restore healthy tissue function.\u003cbr\u003eOther research suggests that finding ways to inhibit TGFBR may also help to treat cancer. Samples from cancerous tissues show overexpression of TGFBR - presumably an adaptation by the tumor to accelerate its growth. Higher levels of TGFBR lead to faster cell division and growth and encourages the formation of more aggressive tumors that grow and spread faster. Inhibiting the TGFBR signaling pathways, therefore, could be a way to combat cancer, particularly at the end-stage of the disease.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTGFB Receptor Structure\u003c\/strong\u003e\u003cbr\u003eTGFBR has been categorized into a variety of distinct isoforms that are both homo and heterodimeric.\u003cbr\u003eResearchers classify three TGF beta factor superfamily receptors, which all have different structures and functions.\u003cbr\u003eTGF beta receptor 1, also sometimes called ALK5 and TGF beta receptor 2, both have similar ligand-binding preferences. The differences between them are subtle and only visible through a careful process of peptide mapping. Both of them have a high affinity for TGF-beta-1 and a low preference for TGF-beta-2.\u003cbr\u003eTGF beta receptor 3 likes to bind to homodimeric versions of TFG-beta-1 and TGF-beta-2. It will also link with the heterodimer TGF-beta-1.2 and TGF-beta-3.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTGFBR Mechanisms\u003c\/strong\u003e\u003cbr\u003eThe majority of TGFBRs resides in cells. However, following AKT activation in response to insulin or other growth factors, it soon makes its way to the surface to increase affinity for TGF-beta. Interestingly, research indicates that TGF-beta induces the translocation of its own receptors to the cell surface, enhancing the mechanism of action. They also discovered that TGF-beta-induced increases in receptor populations at the cell surface amplified the work of SMAD family members,\u003cbr\u003eThe role of bone morphogenic protein 4 is essential too. It increases AKT activation, which, in turn, increases the TGFBR levels at the cell surface. This finding provides a context for TGF-beta signaling during development.\u003c\/p\u003e","products":[{"product_id":"tgfbr1-human","title":"TGFBR1 Human","description":"\u003cp\u003eTransforming Growth Factor Beta Receptor I Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eTGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, tbetaR-I, TGFR-1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174657097812,"sku":"PKA-111","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174657130580,"sku":"PKA-111","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174657163348,"sku":"PKA-111","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-tgfbr1-human-PKA-111.png?v=1776712044"},{"product_id":"tgfbr1-protein","title":"TGFBR1 Human, Active","description":"\u003cp\u003eTransforming Growth Factor Beta Receptor 1 Human Recombinant, Active\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eTGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, tbetaR-I, TGFR-1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174658506836,"sku":"PKA-135","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174658539604,"sku":"PKA-135","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174658572372,"sku":"PKA-135","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-tgfbr1-protein-PKA-135.png?v=1776712049"},{"product_id":"tgfbr2-human","title":"TGFBR2 Human","description":"\u003cp\u003eTransforming Growth Factor Beta Receptor II Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eAAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII, TGFBR-2, TGF-beta receptor type-2, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TGF-beta type II receptor, TbetaR-II, TGFBR2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174659981396,"sku":"PKA-261","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174660014164,"sku":"PKA-261","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174660046932,"sku":"PKA-261","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-tgfbr2-human-PKA-261.png?v=1776712057"},{"product_id":"tgfbr2-human-his","title":"TGFBR2 Human, His","description":"\u003cp\u003eTransforming Growth Factor Beta Receptor II, His Tag Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eAAT3,\nFAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII, TGFBR-2, TGF-beta\nreceptor type-2, Transforming growth factor-beta receptor type II, TGF-beta\nreceptor type II, TGF-beta type II receptor, TbetaR-II, TGFBR2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174660702292,"sku":"PKA-088","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174660735060,"sku":"PKA-088","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174660767828,"sku":"PKA-088","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-tgfbr2-human-his-PKA-088.png?v=1776712053"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_361b86b9-06dc-4345-8925-dfd84d44804e.png?v=1700648036","url":"https:\/\/prospecbio.com\/collections\/tgfbr.oembed","provider":"prospecbio","version":"1.0","type":"link"}