{"title":"TCL","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout TCL:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eTCL1A, also known as T-cell leukemia\/lymphoma protein 1A, and TCL1B, also known as T-cell leukemia\/lymphoma protein 1B, are both proteins in humans. These proteins are both notable for being implicated in the development of mature T cell leukemia, which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha or TCR-beta regulatory elements\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTCL Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe functions of TCL1A are to enhance the phosphorylation and activation of AKT1, AKT2, and AKT3, to promote the nuclear translocation of AKT 1, to enhance cell proliferation, and to stabilize mitochondrial membrane potential and promote cell survival. TCL1B acts as an Akt kinase co-activator and enhances the phosphorylation and activation of AKT1 and AKT2\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTCL Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe exact mechanisms by which TCL1A regulates tumor development in non-Hodgkin's lymphoma are not yet fully understood, but it is thought to play a role in the pathogenesis of other B-cell non-Hodgkin’s lymphoma malignancies. The mechanisms of TCL1B are thought to be analogous to the mechanisms of TCL1A.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTCL Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eTCL1A interacts with HIST3H2A (Histone H2A type 3), ATM (ATM Serine\/Threonine Kinase), AKT1 (AKT Serine\/Threonine Kinase 1), AKT2 (AKT Serine\/Threonine Kinase 2), and (AKT Serine\/Threonine Kinase 3). TCL1B also interacts with AKT, but furthermore, has interactions with MED1 (Mediator Complex Subunit 1) and MED28 ((Mediator Complex Subunit 28).\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eTCL Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eTCL1A structure is composed of a hydrophobic core surrounded by two 4-stranded β-sheets. One sheet is composed of shorter strands and the other of longer strands, both linked by a long and flexible loop between strands βD and βE.\u003c\/p\u003e","products":[{"product_id":"tcl1a-human","title":"TCL1A Human","description":"\u003cp\u003eT-cell Leukemia\/Lymphoma 1A Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eT-cell leukemia\/lymphoma protein 1A, Protein p14 TCL1, Oncogene TCL-1, Oncogene TCL1, TCL1A, TCL1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43174591987796,"sku":"PRO-726","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174592020564,"sku":"PRO-726","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174592053332,"sku":"PRO-726","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-tcl1a-human-PRO-726.png?v=1776711784"},{"product_id":"tcl1b-human","title":"TCL1B Human","description":"\u003cp\u003eT-cell Leukemia\/Lymphoma 1B Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eT-Cell Leukemia\/Lymphoma 1B, Oncogene TCL-1B, Syncytiotrophoblast-Specific Protein, SYN-1, TML1, T-Cell Leukemia\/Lymphoma Protein 1B, T-Cell Lymphoma\/Leukemia 1B, TCL1\/ MTCP1-Like 1, TCL1, Oncogene TCL1B, TCL1\/MTCP1-Like Protein 1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174592905300,"sku":"PRO-1749","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174592938068,"sku":"PRO-1749","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174592970836,"sku":"PRO-1749","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-tcl1b-human-PRO-1749.png?v=1776711788"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_e042ccc9-4734-45d3-866f-469ec012ee44.png?v=1700648024","url":"https:\/\/prospecbio.com\/collections\/tcl.oembed","provider":"prospecbio","version":"1.0","type":"link"}