{"title":"Synuclein","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SNCA \/ Synuclein:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSynucleins are soluble proteins found in all vertebrates that are largely expressed in brain tissue and some malignancies.\u003cbr data-mce-fragment=\"1\"\u003eThe term is a combination of the words \"synapse\" and \"nucleus,\" as discovered in the synapses of the electric ray's electromotor nucleus.\u003cbr data-mce-fragment=\"1\"\u003eThere are three known proteins in the synuclein family: alpha-synuclein, beta-synuclein, and gamma-synuclein. When alpha-synuclein was shown to be mutated in multiple families with autosomal dominant Parkinson's disease, researchers became interested in the synuclein family.\u003cbr data-mce-fragment=\"1\"\u003eA highly conserved alpha-helical lipid-binding motif shared by all synucleins is similar to the class-A2 lipid-binding domains of exchangeable apolipoproteins. Members of the synuclein family are not found outside of vertebrates, albeit they share some structural similarities with plant 'late-embryo-abundant' proteins.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSNCA Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eA-synuclein N-terminus has seven 11-residue repeats that are predicted to create an amphipathic alpha-helix. The repetitions are extremely conserved, both across species and among the three isoforms. The motif is also distinct, with no other sequences found outside of the synuclein family. Furthermore, this sequence has only been found in vertebrates, including the lamprey.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSynuclein Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eNone of the synuclein proteins have been shown to have normal cellular activities. Some evidence suggests that it plays a role in the regulation of membrane stability and\/or turnover. Alpha-synuclein mutations have been linked to early-onset familial Parkinson's disease, and the protein accumulates inappropriately in Parkinson's disease, Alzheimer's disease, Lewy body disease, and other neurodegenerative illnesses. The expression of the gamma-synuclein protein in breast cancers is a marker for tumor progression.\u003c\/p\u003e","products":[{"product_id":"snca-1-60-human","title":"SNCA 1-60 Human","description":"\u003cp\u003eAlpha Synuclein 1-60 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eAlpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, PD1, PARK1, PARK4, MGC110988, a-Synuclein, 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