{"title":"Syndecan","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SDC \/ Syndecan:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSyndecans are proteins that are believed to act as coreceptors, particularly for G protein-coupled receptors.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSDC Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eIt is thought that these core proteins carry three to five heparan sulfate and chondroitin sulfate chains. There are four members of the Syndecan family, with 1 and 3, and 2 and 4 making up subfamilies. This happened by gene duplication and changing course of evolution from a single ancestral gene.\u003cbr data-mce-fragment=\"1\"\u003eAll syndecans have an N-terminal signal peptide, an ectodomain, a short C-terminal cytoplasmic domain and a single hydrophobic transmembrane domain. They are anchored to plasma membrane through a 24\/25 amino acid hydrophopic transmembrane domain.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSyndecan Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eGlycosaminoglycans help the interaction of syndecans with extracellular ligands. The glycosaminoglycans have differen structures to accommodate the needs of the region, depending on the localization of the syndecan. From here, the syndecans are known to form homologous oligomers that are important for their future functions.\u003cbr data-mce-fragment=\"1\"\u003eThe four categories of functions of a syndecan are as follows:\u003cbr data-mce-fragment=\"1\"\u003e●Growth factor receptor activation\u003cbr data-mce-fragment=\"1\"\u003e●Matrix adhesion\u003cbr data-mce-fragment=\"1\"\u003e●Cell-cell adhesion\u003cbr data-mce-fragment=\"1\"\u003e●Tumor suppression and progressions through the prevention of cellular profileration of tumor cell lines.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSDC Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThey are under the class of proteoglycans which mean they can interact with a wide range of ligands. This includes things like fibroblast growth factors, transforming growth factor-beta fibronectin and vascular endothelial growth factor. Interactions that happen between fibronectin and some syndecans can be modulated by the extracellular matrix protein tenascin C.\u003c\/p\u003e","products":[{"product_id":"sdc1-human","title":"SDC1 Human","description":"\u003cp\u003eSyndecan-1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eHeparan Sulfate proteoglycan fibroblast growth factor receptor, syndecan proteoglycan 1, Syndecan 1, SYND1, CD138 antigen, SDC.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174079201364,"sku":"PRO-1065","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174079234132,"sku":"PRO-1065","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174079266900,"sku":"PRO-1065","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sdc1-human-PRO-1065.png?v=1776710009"},{"product_id":"sdc2-human","title":"SDC2 Human","description":"\u003cp\u003eSyndecan-2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSyndecan 2, Heparan Sulfate Proteoglycan 1 Cell Surface-Associated, Heparan Sulfate Proteoglycan Core Protein, Syndecan Proteoglycan 2, Fibroglycan, HSPG1, SYND2, HSPG, Cell Surface-Associated Heparan Sulfate Proteoglycan 1, CD362 Antigen, Syndecan-2, CD362, SDC2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174081265748,"sku":"PRO-2449","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174081298516,"sku":"PRO-2449","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174081331284,"sku":"PRO-2449","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sdc2-human-PRO-2449.png?v=1776445468"},{"product_id":"sdc4-human","title":"SDC4 Human","description":"\u003cp\u003eSyndecan-4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSDC-4, SYND4, SYND-4, Amphiglycan, Ryudocan core protein, Syndecan-4.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174082084948,"sku":"PRO-778","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174082117716,"sku":"PRO-778","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174082150484,"sku":"PRO-778","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sdc4-human-PRO-778.png?v=1776445478"},{"product_id":"sdcbp-human","title":"SDCBP Human","description":"\u003cp\u003eSyndecan Binding Protein Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSYCL, syntenin-1, Syndecan-binding protein 1, Scaffold protein Pbp1, MDA-9, Melanoma differentiation-associated protein 9, TACIP18, Pro-TGF-alpha cytoplasmic domain-interacting protein 18.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174083919956,"sku":"PRO-036","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174083952724,"sku":"PRO-036","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174083985492,"sku":"PRO-036","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sdcbp-human-PRO-036.png?v=1776445482"},{"product_id":"sdcbp2-human","title":"SDCBP2 Human","description":"\u003cp\u003eSyndecan Binding Protein 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSITAC, SITAC18, ST-2, Syntenin-2, Syndecan-binding protein 2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174084640852,"sku":"PRO-1297","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174084673620,"sku":"PRO-1297","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174084706388,"sku":"PRO-1297","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sdcbp2-human-PRO-1297.png?v=1776445487"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_7c644c71-91fd-4398-a339-2ffae106b9bd.png?v=1700647870","url":"https:\/\/prospecbio.com\/collections\/syndecan.oembed","provider":"prospecbio","version":"1.0","type":"link"}