{"title":"Synaptotagmin","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SYT \/ Synaptotagmin:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSynaptotagmins (SYTs) are membrane-trafficking proteins. They regulate the speed and synchronicity of calcium-dependent neurotransmission. Eight out of the fifteen synaptotagmins directly bind to calcium. These are synaptotagmins 1, -2, -3, -5, -6, -7, -9, and -10 The other seven lack the necessary critical residues for calcium binding and hence operate indirectly.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSYT Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eIt is believed that Synaptotagmin plays a role in exocytosis. Specifically, the calcium-binding synaptotagmins bind to the SNARE complex. This results in the fusion clamp effect of complexin being released and hence allows vesicle fusion to occur. By extension, Synaptotagmin is therefore believed to play a role in recovery from injury.\u003cbr data-mce-fragment=\"1\"\u003eSynaptotagmin is also believed to have a significant influence on the development of neural connections and hence on the ability to learn. It has also been linked with bipolar disorder.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSynaptotagmin Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe Synaptotagmin-1 gene is located in position 21.2 of the q arm of chromosome 12 (12q21.2). The Synaptotagmin protein is formed as an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSYT Interaction\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSynaptotagmins interact with the intracellular loop I-II of neuronal voltage-sensitive sodium channels. They specifically interact with calcium either binding directly to it or acting as a sensor for its presence.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSynaptotagmin Mechanism of action\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eAlthough there is a large body of data on this subject, relatively little is known about the molecular mechanism of this highly regulated fusion machinery. It is, however, known that synaptotagmins react to Ca2+ influx by triggering the fusion of synaptic vesicles with the active zone in the presynaptic terminal.\u003c\/p\u003e","products":[{"product_id":"syt1-human","title":"SYT1 Human","description":"\u003cp\u003eSynaptotagmin I Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSynaptotagmin-1, Synaptotagmin I, SytI, p65, SYT1, SVP65, SYT.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174503186516,"sku":"PRO-239","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174503219284,"sku":"PRO-239","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174503252052,"sku":"PRO-239","price":1100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-syt1-human-PRO-239.png?v=1776711447"},{"product_id":"syt11-human","title":"SYT11 Human","description":"\u003cp\u003eSynaptotagmin XI Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSynaptotagmin\nXI, SytXI, Synaptotagmin 12, KIAA0080, SYT12, Synaptotagmin-11.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174503972948,"sku":"PRO-2301","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174504005716,"sku":"PRO-2301","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174504038484,"sku":"PRO-2301","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-syt11-human-PRO-2301.png?v=1776711452"},{"product_id":"syt13-human","title":"SYT13 Human","description":"\u003cp\u003eSynaptotagmin XIII Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSynaptotagmin XIII, KIAA1427, synaptotagmin-13, sytXIII.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174504857684,"sku":"PRO-1550","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174504890452,"sku":"PRO-1550","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174504923220,"sku":"PRO-1550","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-syt13-human-PRO-1550.png?v=1776711456"},{"product_id":"syt3-human","title":"SYT3 Human","description":"\u003cp\u003eSynaptotagmin III Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSynaptotagmin III, SYT3, SytIII, synaptotagmin-3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174505873492,"sku":"PRO-1937","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174505906260,"sku":"PRO-1937","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174505939028,"sku":"PRO-1937","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-syt3-human-PRO-1937.png?v=1776711461"},{"product_id":"syt4-human","title":"SYT4 Human","description":"\u003cp\u003eSynaptotagmin IV Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eHsT1192, KIAA1342, Synaptotagmin-4, Synaptotagmin IV, SytIV, SYT4.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174506922068,"sku":"PRO-1375","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174506954836,"sku":"PRO-1375","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174506987604,"sku":"PRO-1375","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-syt4-human-PRO-1375.png?v=1776711465"},{"product_id":"syt5-human","title":"SYT5 Human","description":"\u003cp\u003eSynaptotagmin V Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSynaptotagmin V, Synaptotagmin 5, synaptotagmin-5, sytV, SytV.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174508068948,"sku":"PRO-1738","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174508101716,"sku":"PRO-1738","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174508134484,"sku":"PRO-1738","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-syt5-human-PRO-1738.png?v=1776711470"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_1deefce0-ea8a-427c-8d12-9656b17fbe8c.png?v=1700648008","url":"https:\/\/prospecbio.com\/collections\/synaptotagmin.oembed","provider":"prospecbio","version":"1.0","type":"link"}