{"title":"Synaptosomal Associated Protein","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SNAP \/ Synaptosomal Associated Protein:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSynaptosomal-Associated Protein, 25kDa (SNAP-25) is one of the SNARE proteins and forms part of the trans-SNARE complex. As such, its main function is to govern vesicle fusion. This is mainly, although not uniquely, through exocytosis.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSNAP Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe primary function of SNAP-25 is to regulate the fusion of vesicles with the target membrane. It also plays a role in synaptogenesis, neuronal plasticity, postsynaptic receptor trafficking, and spine morphogenesis and density.\u003cbr data-mce-fragment=\"1\"\u003eSNAP-25 also influences non-neural processes including metabolism. Issues with SNAP-25 are linked with several neurodevelopmental disorders. These include attention deficit hyperactivity disorder (ADHD), schizophrenia, Alzheimer's disease, bipolar disorder, epilepsy, and neuroticism. It is linked with neonatal development and learning disabilities.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSynaptosomal Associated Protein Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe SNAP-25 gene is located in position 12.2 of the p arm of chromosome 20 (20p12.2). It has 10 exons. The SNAP-25 protein is a 25 kDa protein. It consists of 206 amino acids.\u003cbr data-mce-fragment=\"1\"\u003eThe SNAP-25 protein is divided into two forms. These are SNAP25a and SNAP25b. Both are structured as an N-terminal α-helix, a random coil linker region with four cysteines, and a C-terminal α-helix. In SNAP25a, the four cysteines are clustered towards the center. In SNAP25b the four cysteines are clustered towards the C-terminus.\u003cbr data-mce-fragment=\"1\"\u003eSNAP25a is diffuse whereas SNAP25b is only located in terminals and varicosities.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSNAP Interaction\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eCurrently, SNAP-25 is known to have 13 interactions. These are:\u003cbr data-mce-fragment=\"1\"\u003eCPLX1\u003cbr data-mce-fragment=\"1\"\u003eITSN1\u003cbr data-mce-fragment=\"1\"\u003eKIF5B\u003cbr data-mce-fragment=\"1\"\u003eSNAPAP\u003cbr data-mce-fragment=\"1\"\u003eSTX11\u003cbr data-mce-fragment=\"1\"\u003eSTX1A\u003cbr data-mce-fragment=\"1\"\u003eSTX2\u003cbr data-mce-fragment=\"1\"\u003eSTX4\u003cbr data-mce-fragment=\"1\"\u003eSTY1\u003cbr data-mce-fragment=\"1\"\u003eSyntaxin 3\u003cbr data-mce-fragment=\"1\"\u003eTRIM9\u003cbr data-mce-fragment=\"1\"\u003eVAMP2\u003cbr data-mce-fragment=\"1\"\u003eSynaptotagmin (in the presence of Ca2+)\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSynaptosomal Associated Protein Mechanism of action\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSNAP-25 forms a tight complex that bonds the synaptic vesicle and plasma membranes.\u003c\/p\u003e","products":[{"product_id":"napa-human","title":"NAPA Human","description":"\u003cp\u003eN-Ethylmaleimide-Sensitive Factor Attachment Protein, Alpha Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSNAPA, SNAP-alpha.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174170361940,"sku":"PRO-250","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174170394708,"sku":"PRO-250","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174170427476,"sku":"PRO-250","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-napa-human-PRO-250.png?v=1776444715"},{"product_id":"snap23-human","title":"SNAP23 Human","description":"\u003cp\u003eSynaptosomal-associated protein 23 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSNAP23A, SNAP23B, HsT17016, Synaptosomal-associated protein 23, Vesicle-membrane fusion protein SNAP-23, SNAP23.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174265225300,"sku":"PRO-659","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174265258068,"sku":"PRO-659","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174265290836,"sku":"PRO-659","price":2900.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-snap23-human-PRO-659.png?v=1776710362"},{"product_id":"snap25-celegans","title":"SNAP25 C.elegans","description":"\u003cp\u003eSynaptosomal-associated protein 25kDa C.elegans Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSuper-Protein, SUP, RIC4, SEC9, SNAP, RIC-4, SNAP25, SNAP-25, Synaptosomal-associated protein 25, Synaptosomal-associated 25 kDa protein, FLJ23079, bA416N4.2, dJ1068F16.2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43174267551828,"sku":"PRO-396","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174267584596,"sku":"PRO-396","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174267617364,"sku":"PRO-396","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-snap25-celegans-PRO-396.png?v=1776710371"},{"product_id":"snap25b-human","title":"SNAP25 Human","description":"\u003cp\u003eSynaptosomal-associated protein 25kda Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSuper-Protein, SUP, RIC4, SEC9, SNAP, RIC-4, SNAP25, SNAP-25, Synaptosomal-associated protein 25, Synaptosomal-associated 25 kDa protein, FLJ23079, bA416N4.2, dJ1068F16.2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174268469332,"sku":"PRO-635","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174268502100,"sku":"PRO-635","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174268534868,"sku":"PRO-635","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-snap25b-human-PRO-635.png?v=1776710380"},{"product_id":"snap25-human","title":"SNAP25 Human, His","description":"\u003cp\u003eSynaptosomal-associated protein 25kDa Human Recombinant, His Tag\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSuper-Protein, SUP, RIC4, SEC9, SNAP, RIC-4, SNAP25, SNAP-25, Synaptosomal-associated protein 25, Synaptosomal-associated 25 kDa protein, FLJ23079, bA416N4.2, dJ1068F16.2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43174269517908,"sku":"PRO-573","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174269550676,"sku":"PRO-573","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174269583444,"sku":"PRO-573","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-snap25-human-PRO-573.png?v=1776710375"},{"product_id":"snapin-human","title":"SNAPIN Human","description":"\u003cp\u003eSNAP Associated Protein Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSNAPAP, SNARE-associated protein Snapin, Synaptosomal-associated protein 25-binding protein, SNAP-associated protein, SNAPIN, SNAP25BP.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43174271549524,"sku":"PRO-663","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174271582292,"sku":"PRO-663","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174271615060,"sku":"PRO-663","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-snapin-human-PRO-663.png?v=1776710389"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_03660324-9ae3-4e6d-88f6-3f0ce24e4751.png?v=1700647687","url":"https:\/\/prospecbio.com\/collections\/synaptosomal-associated-protein.oembed","provider":"prospecbio","version":"1.0","type":"link"}