{"title":"Synaptobrevin","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout VAMP \/ Synaptobrevin:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSynaptobrevins (synaptobrevin isotypes 1-2) belong to the vesicle-associated membrane protein (VAMP) family. They are small integral membrane proteins of secretory vesicles. Synaptobrevin is one of the SNAP REceptor (SNARE) proteins used in exocytosis.\u003cbr data-mce-fragment=\"1\"\u003eMutations in the VAMP proteins are associated with neurodevelopmental disorders. These include autism, epilepsy, movement disorders, and synaptopathy.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eVAMP Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eAs one of the SNARE proteins, the main function of Synaptobrevin is to mediate the fusion of vesicles with the target membrane. This is mainly through exocytosis. The SNARE proteins can, however, also mediate the fusion of vesicles with membrane-bound compartments, for example, lysosomes.\u003cbr data-mce-fragment=\"1\"\u003eFor clinical (and cosmetic) reasons, most attention has been paid to the SNARES that mediate the neurotransmitter release of synaptic vesicles in neurons. This includes Synaptobrevin. This protein is known to be degraded by tetanospasmin. Tetanospasmin is derived from Clostridium tetani. This is the bacteria that causes tetanus.\u003cbr data-mce-fragment=\"1\"\u003eIn the cosmetic field (and, to some extent, the medical one) Synaptobrevin is also noted as being a target for the botulinum toxin. This is produced by the Clostridium botulinum, itself a relative of the Clostridium tetani bacterium.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSynaptobrevin Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSynaptobrevin is structured as an α-helix (Alpha helix). This type of structure is also known as a 3.613-helix. Synaptobrevin forms one of the four α-helices in the SNARE complex. The other three are syntaxin (one) and SNAP-25 (two, in neurons).\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eVAMP Interaction\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSynaptobrevin is best known for its interaction with Synaptophysin. This interaction promotes the formation of functional SNARE complexes. It, therefore, plays a key role in modulating synaptic efficiency.\u003cbr data-mce-fragment=\"1\"\u003eSynaptobrevin is present in several human proteins. These are:\u003cbr data-mce-fragment=\"1\"\u003eSEC22A\u003cbr data-mce-fragment=\"1\"\u003eSEC22B\u003cbr data-mce-fragment=\"1\"\u003eSYBL1\u003cbr data-mce-fragment=\"1\"\u003eVAMP1\u003cbr data-mce-fragment=\"1\"\u003eVAMP2\u003cbr data-mce-fragment=\"1\"\u003eVAMP3\u003cbr data-mce-fragment=\"1\"\u003eVAMP4\u003cbr data-mce-fragment=\"1\"\u003eVAMP5\u003cbr data-mce-fragment=\"1\"\u003eVAMP8\u003cbr data-mce-fragment=\"1\"\u003eYKT6\u003c\/p\u003e","products":[{"product_id":"vamp1-human","title":"VAMP1 Human","description":"\u003cp\u003eSynaptobrevin-1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eVesicle-associated membrane protein 1, SYB1, VAMP-1, Synaptobrevin-1, VAMP1, DKFZp686H12131.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175089373268,"sku":"PRO-577","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175089406036,"sku":"PRO-577","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175089438804,"sku":"PRO-577","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-vamp1-human-PRO-577.png?v=1776714217"},{"product_id":"vamp2-human","title":"VAMP2 Human","description":"\u003cp\u003eSynaptobrevin-2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eVesicle-associated membrane protein 2, SYB2, VAMP-2, Synaptobrevin-2, VAMP2, FLJ11460.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175091929172,"sku":"PRO-578","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175091961940,"sku":"PRO-578","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175091994708,"sku":"PRO-578","price":3000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-vamp2-human-PRO-578.png?v=1776714225"},{"product_id":"synaptobrevin-2-human","title":"VAMP2 Human, (1-94)","description":"\u003cp\u003eSynaptobrevin-2 Human Recombinant, (1-94)\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eVesicle Associated Membrane Protein 2, Vesicle-Associated Membrane Protein 2, Synaptobrevin 2, VAMP-2, SYB2, Synaptobrevin-2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43175093108820,"sku":"PRO-2644","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43175093141588,"sku":"PRO-2644","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43175093174356,"sku":"PRO-2644","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-synaptobrevin-2-human-PRO-2644.png?v=1776711434"},{"product_id":"vamp2-mouse-3","title":"VAMP2 Mouse","description":"\u003cp\u003eSynaptobrevin-2 Recombinant Mouse\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eVesicle-associated membrane protein 2, VAMP-2, Synaptobrevin-2, Vamp2, Syb2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43175093960788,"sku":"PRO-2415","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43175093993556,"sku":"PRO-2415","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43175094026324,"sku":"PRO-2415","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-vamp2-mouse-3-PRO-2415.png?v=1776714232"},{"product_id":"vamp3-human","title":"VAMP3 Human","description":"\u003cp\u003eSynaptobrevin-3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eVAMP3, VAMP-3, Cellubrevin, Vesicle-Associated Membrane Protein 3, Synaptobrevin-3, CEB, SYB3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175096156244,"sku":"PRO-652","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43175096189012,"sku":"PRO-652","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175096221780,"sku":"PRO-652","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-vamp3-human-PRO-652.png?v=1776714242"},{"product_id":"vamp4-human","title":"VAMP4 Human","description":"\u003cp\u003eVesicle-associated membrane protein 4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eVesicle-associated membrane protein 4, VAMP-4, VAMP4, VAMP24.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175097008212,"sku":"PRO-714","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175097040980,"sku":"PRO-714","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175097073748,"sku":"PRO-714","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-vamp4-human-PRO-714.png?v=1776714246"},{"product_id":"vamp5-human","title":"VAMP5 Human","description":"\u003cp\u003eVesicle-associated membrane protein 5 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eVAMP5, Vesicle-associated membrane protein 5, VAMP-5, Myobrevin, 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