{"title":"Surfeit","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SURF \/ Surfeit:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSurfeit locus protein 1 (SURF1) is a multi-pass protein believed to be used in the mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complexes (also known as Complex IV, COX, and\/or MITRAC complex). It thus plays a role in the regulation of the cytochrome c oxidase assembly.\u003cbr data-mce-fragment=\"1\"\u003eMutations in SURF1 are strongly linked with Leigh syndrome. This in turn is linked with systemic cytochrome c oxidase (complex IV) deficiency, and Charcot-Marie-Tooth disease 4K (CMT4K).\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSURF Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe SURF1 protein is found in the inner mitochondrial membrane. It is believed to play a role in the biogenesis of Complex IV. Complex IV plays a vital role in oxidative phosphorylation. It attracts electrons created through previous steps in oxidative phosphorylation and protons from inside the mitochondrion. Using these, it converts oxygen to water.\u003cbr data-mce-fragment=\"1\"\u003eAdditionally, Complex IV sends protons across the specialized membrane inside the mitochondrion. This creates energy which is then converted into adenosine triphosphate (ATP). This is the form of energy mainly used for cellular processes.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSurfeit Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe SURF1 gene forms part of the surfeit gene cluster. These genes are very tightly linked but do not have similar sequences. The SURF1 gene is located in position 34.2 of the q arm of chromosome 9 (9q34.2). It has 9 exons. The SURF1 protein is a 33.3 kDa protein. It consists of 300 amino acids.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSURF Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSURF1 has a total of 11 binary protein-protein interactions. Of these, 8 are co-complex interactions. Genes known to interact with SURF1 include:\u003cbr data-mce-fragment=\"1\"\u003eCOA1\u003cbr data-mce-fragment=\"1\"\u003eCOA3\u003cbr data-mce-fragment=\"1\"\u003eCOX6C\u003cbr data-mce-fragment=\"1\"\u003eCOX14\u003cbr data-mce-fragment=\"1\"\u003ePTGES3\u003cbr data-mce-fragment=\"1\"\u003eSLC25A5\u003c\/p\u003e","products":[{"product_id":"surf1-human","title":"SURF1 Human","description":"\u003cp\u003eSurfeit-1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSURF1, SURF-1, Surfeit locus protein 1, Surfeit 1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174496010324,"sku":"PRO-764","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174496043092,"sku":"PRO-764","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174496075860,"sku":"PRO-764","price":2250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-surf1-human-PRO-764.png?v=1776711403"},{"product_id":"surf2-human","title":"SURF2 Human","description":"\u003cp\u003eSurfeit-2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSurfeit 2, SURF-2, SURF2, Surfeit locus protein 2, Surfeit-2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174496993364,"sku":"PRO-1470","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174497026132,"sku":"PRO-1470","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174497058900,"sku":"PRO-1470","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-surf2-human-PRO-1470.png?v=1776711407"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_ca143606-5527-49c7-aabe-38ab38b5b841.png?v=1700648007","url":"https:\/\/prospecbio.com\/collections\/surfeit.oembed","provider":"prospecbio","version":"1.0","type":"link"}