{"title":"Sorting Nexin","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SNX \/ Sorting Nexin:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSorting nexins (commonly shortened to SNX) are proteins. This is a large group, which you’ll find in the cytoplasm. They are able to associate with membranes because of their lipid-binding PX domain (this is a phospholipid-binding motif), or they can do it through protein-protein interactions, if it’s related to membrane-associated protein complexes. While the research has been limited, researchers have found that there are some members of the family that can facilitate protein sorting.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSNX Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eIn terms of structure, SNX consists of a PX domain or they’ll have a structure that consists of the PX as well as additional domains. There’s a subgroup of SNX that you’ll find in humans -- these run from SNX1 through to SNX9, and then SNX18, SNX30, SNX32, and SNX33 -- and these contain a BAR domain that you’ll find at their C-terminus. In terms of homology, they’re close to several yeast proteins, such as Vps5p and Mvp1p.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSorting Nexin Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSome of the SNX family have been shown to bind to multiple receptor tyrosine kinases -- the research shows that receptors for epidermal growth factor, platelet-derived growth factor, and also insulin. The most novel member of the sorting nexins family is SNX6, which researchers have observed will interact with members of the transforming growth factor-beta family of receptor threonine kinases. Researchers have also observed strong heteromeric interactions among SNX1, -2, -4, and -6. This indicates a possibility that there’s a formation in the vivo of oligomeric complexes. This indicates that there may be a relationship between SNX and the receptor serine-threonine kinases.\u003c\/p\u003e","products":[{"product_id":"snx1-human","title":"SNX1 Human","description":"\u003cp\u003eSorting Nexin 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eHsT17379, SNX1A, Vps5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174312050772,"sku":"PRO-665","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174312083540,"sku":"PRO-665","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174312116308,"sku":"PRO-665","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-snx1-human-PRO-665.png?v=1776710586"},{"product_id":"snx3-human","title":"SNX3 Human","description":"\u003cp\u003eSorting Nexin 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSorting nexin-3, Protein SDP3, SNX3, SDP3, Grd19, MCOPS8.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174312935508,"sku":"PRO-246","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174312968276,"sku":"PRO-246","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174313001044,"sku":"PRO-246","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-snx3-human-PRO-246.png?v=1776710590"},{"product_id":"snx5-human","title":"SNX5 Human","description":"\u003cp\u003eSorting Nexin 5 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSorting nexin-5 isoform a, Sorting nexin-5, SNX5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174314016852,"sku":"PRO-786","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174314049620,"sku":"PRO-786","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174314082388,"sku":"PRO-786","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-snx5-human-PRO-786.png?v=1776710595"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_fe9637f0-594d-4e6a-84e0-c8e52474fa74.png?v=1700647898","url":"https:\/\/prospecbio.com\/collections\/sorting-nexin.oembed","provider":"prospecbio","version":"1.0","type":"link"}