{"title":"SMAD","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SMAD:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSMAD proteins are two protein families of intracellular signaling proteins that play a role in cell-cell communication. They are divided into two groups SMAD1 and SMAD2.\u003cbr data-mce-fragment=\"1\"\u003eThere is also a third group of family members, the SMAD3, which function as transcriptional regulators. They are involved in both signal transduction pathways and in gene transcription regulation.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSMAD Functions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSome common functions include inhibiting the expression of certain genes inside cells. Activating the expression of certain genes inside cells. Change the location, shape, or behavior (depending on function) of a cell.\u003cbr data-mce-fragment=\"1\"\u003eTo be more specific, the main function of the SMAD family is to transmit signals from transforming growth factor-beta (TGF-β). The TGF-beta signaling pathway is a network of molecular interactions that control cell growth and differentiation.\u003cbr data-mce-fragment=\"1\"\u003eHowever, despite their crucial role in transducing TGF-β information, all SMADs are regulated by other TGF-β family members. SMAD proteins are highly specific to the type of TGF-β they recognize; for example, only SMAD1 and 2 can be activated by TGF-β1.\u003cbr data-mce-fragment=\"1\"\u003eThese proteins are part of a pathway that is essential for many developmental processes in mammals, such as embryonic patterning (formation of body structures), limb formation, heart development, and neural crest cell migration during head development.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSMAD Mechanisms\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eOne mechanism through which these proteins function is through regulating transcription of certain genes, such as Hox genes during development. The SMAD proteins have also been found to play a role in diseases, including cancer.\u003cbr data-mce-fragment=\"1\"\u003eSMAD proteins control cell processes and behaviors without being affected by external stimuli. They can communicate over a large distance to control other cells or organs for the benefit of the organism as a whole. These proteins play an important role in many biological functions and their mechanisms are vital to the proper function of the human body.\u003c\/p\u003e","products":[{"product_id":"smad2-human","title":"SMAD2 Human","description":"\u003cp\u003eSMAD Family Member 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eJV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2, MGC22139, MGC34440, SMAD2, Mothers against decapentaplegic homolog 2, Mothers against DPP homolog 2, Mad-related protein 2, SMAD 2, SMAD family member 2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174254608468,"sku":"PRO-691","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174254641236,"sku":"PRO-691","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174254674004,"sku":"PRO-691","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-smad2-human-PRO-691.png?v=1776710312"},{"product_id":"smad3-human","title":"SMAD3 Human","description":"\u003cp\u003eMothers Against Decapentaplegic Homolog 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMADH3, JV15-2, HSPC193, HsT17436, MGC60396, DKFZp586N0721, DKFZp686J10186, SMAD3, Mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, MAD homolog 3, Mad3, hMAD-3, SMAD family member 3, SMAD 3, hSMAD3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174255427668,"sku":"PRO-751","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174255460436,"sku":"PRO-751","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174255493204,"sku":"PRO-751","price":2250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-smad3-human-PRO-751.png?v=1776710317"},{"product_id":"smad4-human","title":"SMAD4 Human","description":"\u003cp\u003eMothers Against Decapentaplegic Homolog 4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eJIP, DPC4, MADH4, SMAD-4, DPC-4, MADH-4, Mothers against decapentaplegic homolog 4, Mothers against DPP homolog 4, SMAD 4, hSMAD4, Deletion target in pancreatic carcinoma 4, SMAD4, SMAD family member 4.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43174256541780,"sku":"PRO-459","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174256574548,"sku":"PRO-459","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174256607316,"sku":"PRO-459","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-smad4-human-PRO-459.png?v=1776710321"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_3f26dc63-90b9-4700-8e78-e4dce9aac111.png?v=1700647895","url":"https:\/\/prospecbio.com\/collections\/smad.oembed","provider":"prospecbio","version":"1.0","type":"link"}