{"title":"SLAM Family","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SLAMF \/ SLAM Family:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSLAMF stands for Signaling Lymphocytic Activation Molecule family. They’re involved in cell-to-cell adhesion, during the antigen presentation. They’re expressed in immune cells. They physically associate with SAP-related adaptors. There’s always a growing consensus that the SLAM family -- along with the SAP family -- play a prominent role in the development and maintenance of multiple immune cell types. When the SAP family is not present, the SLAM family switches function, which means they can mediate inhibitory signals that aim to suppress immune cell functions.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSLAMF Members\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThere are multiple members of the SLAM family; they are numbered Slam1 through Slam9. They work as receptors that can work directly with microbes, because they’re cell surface transmembrane. That can cause phagocytic cells to move to the area in which they are present. SLAMF1 has been observed to be a receptor for the measles virus, as well as an opsonin for other cells, such as phagocytic cells.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSLAM Family Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThey are also part of the immune cell communication process, and function as co-stimulatory molecules for both T-cells and NK cells. They also work with T helper cell proliferation; they do this by working to increase IFN-Gamma and IL-4 production.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSLAMF Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eEvery member of the SLAM family falls under the classification of type I glycoproteins and shares an amino-terminal IgV variable domain. They also fall under membrane-adjacent IgC2 constant domain, along with immunoreceptor tyrosine-based switch motifs.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSLAM Family Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThey can undergo alternative splicing, which helps to generate different isoforms. SLAM2 and SLAM4 interact with one another but all the other SLAM members are self-ligands.\u003c\/p\u003e","products":[{"product_id":"slamf1-human","title":"SLAMF1 Human","description":"\u003cp\u003eSLAMF1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSignaling lymphocytic activation molecule, CDw150, IPO-3, CD150, SLAMF1, SLAM.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174240092244,"sku":"PRO-1342","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174240125012,"sku":"PRO-1342","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174240157780,"sku":"PRO-1342","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-slamf1-human-PRO-1342.png?v=1776710244"},{"product_id":"slamf1-human-sf9","title":"SLAMF1 Human, Sf9","description":"\u003cp\u003eSLAMF1 Human Recombinant, Sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSignaling lymphocytic activation molecule, CDw150, IPO-3, CD150, SLAMF1, SLAM.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174241042516,"sku":"PRO-2393","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174241075284,"sku":"PRO-2393","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174241108052,"sku":"PRO-2393","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-slamf1-human-sf9-PRO-2393.png?v=1776710249"},{"product_id":"slamf6-human","title":"SLAMF6 Human","description":"\u003cp\u003eSLAMF6 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCD352, KALI, KALIb, Ly108, NTB-A, NTBA, Activating NK receptor, SLAM family member 6.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174242091092,"sku":"PRO-1286","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174242123860,"sku":"PRO-1286","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174242156628,"sku":"PRO-1286","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-slamf6-human-PRO-1286.png?v=1776710258"},{"product_id":"slamf6-human-sf9","title":"SLAMF6 Human, sf9","description":"\u003cp\u003eSLAMF6 Human Recombinant, sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCD352, KALI, KALIb, Ly108, NTB-A, NTBA, Activating NK receptor, SLAM family member 6.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174243893332,"sku":"PRO-2348","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174243926100,"sku":"PRO-2348","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174243958868,"sku":"PRO-2348","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-slamf6-human-sf9-PRO-2348.png?v=1776710262"},{"product_id":"slamf7-human","title":"SLAMF7 Human","description":"\u003cp\u003eSLAMF7 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSLAMF7,\nSLAM Family Member 7, CD2-Like Receptor-Activating Cytotoxic Cells, Membrane Protein FOAP-12, CD2\nSubset 1, Protein 19A, CRACC, CS1, Novel LY9\n(Lymphocyte Antigen 9) Like Protein, CD2-Like Receptor Activating Cytotoxic\nCells, 19A24 Protein, CD319 Antigen, Novel Ly9, CD319, 19A.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174244778068,"sku":"PRO-2261","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174244810836,"sku":"PRO-2261","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174244843604,"sku":"PRO-2261","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-slamf7-human-PRO-2261.png?v=1776710266"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_f1d941f6-3d9d-4ea5-8b07-aca185428884.png?v=1700647892","url":"https:\/\/prospecbio.com\/collections\/slam-family.oembed","provider":"prospecbio","version":"1.0","type":"link"}