{"title":"Signal-Regulatory Protein","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SIRP \/ Signal-Regulatory Protein:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSignal regulatory proteins (SIRPs; also known as myeloid-paired receptors) are membrane proteins produced by leukocytes that regulate immune cells to provide an effective immune response to invaders while minimizing self-harm. They are called CD proteins (cluster of differentiation). SIRP family members' extracellular regions share substantial similarity but have distinct signaling potentials, with each family member mediating either an activating or inhibitory signal. SIRPA (SIRP; CD172a), SIRPB1 (SIRP; CD172b), SIRPB2, SIRPD, and SIRPG (SIRP; CD172g) are the five SIRP genes discovered in humans.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSIRP Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSignal regulatory protein (SIRP) is a membrane receptor that activates CD47 to provide inhibitory signals to myeloid cells. The N-terminal ligand binding domain has a unique immunoglobulin superfamily V-like fold, as shown by the high-resolution x-ray structure. CD47 seems to be bound at a surface including the BC, FG, and DE loops, which separates it from other immunoglobulin superfamily surface proteins that employ the faces of the fold yet resemble antigen receptors.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSignal-Regulatory Protein Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe SIRP interaction is restricted to a single domain, and its usage of an extended DE loop adds to the resemblance with T cell receptor binding and suggests that they are evolutionarily related. The use of loops to construct the CD47-binding surface provides a method for minor sequence alterations to modify binding specificity, explaining why SIRP family members have varied binding characteristics.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSIRP Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSIRPs work with other proteins to exert regulatory effects. One well-known relationship is that between the inhibitory SIRP protein and CD47, which functions as an immuno checkpoint. SIRP\/CD47 blockade is being used as an immuno-oncology approach, with either SIRP or CD47 being inhibited. Because of their structural similarities and the fact that each gene is polymorphic, creating monoclonal antibodies that are selective for particular SIRPs is difficult.\u003c\/p\u003e","products":[{"product_id":"sirpa-human","title":"SIRPA Human","description":"\u003cp\u003eSignal-Regulatory Protein Alpha Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSignal-Regulatory Protein Alpha, SHPS1, CD172\nAntigen-Like Family Member A, Inhibitory Receptor SHPS-1, Macrophage Fusion\nReceptor, PTPNS1, SIRP, P84, BIT, MFR, \n\nBrain-Immunoglobulin-Like Molecule With Tyrosine-Based\nActivation Motifs, Brain Ig-Like Molecule With Tyrosine-Based Activation\nMotifs, Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1, Tyrosine-Protein\nPhosphatase Non-Receptor Type Substrate 1, Tyrosine Phosphatase SHP Substrate\n1, Signal-Regulatory Protein Alpha-1 , ignal-Regulatory Protein Alpha-2, Signal-Regulatory\nProtein Alpha-3, SHP Substrate 1, CD172a Antigen, Myd-1 Antigen, MyD-1 Antigen,\nSirp-Alpha-1, Sirp-Alpha-2, Sirp-Alpha-3, CD172A, SHPS-1, MYD-1, MYD1, Tyrosine-protein\nphosphatase non-receptor type substrate 1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174220234836,"sku":"PRO-2080","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174220267604,"sku":"PRO-2080","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174220300372,"sku":"PRO-2080","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sirpa-human-PRO-2080.png?v=1776445929"},{"product_id":"cd172a-human","title":"SIRPA Human, HEK","description":"\u003cp\u003eSignal-Regulatory Protein Alpha Human Recombinant, HEK\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eTyrosine-protein phosphatase non-receptor type substrate 1 isoform 1, SHP substrate 1, SHPS-1, Brain Iglike molecule with tyrosine-based activation motifs, Bit, CD172 antigen-like family member A, MYD1, PTPNS1, SHPS1,SIRP, Inhibitory receptorSHPS-1, Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha-1, Sirp-alpha-1, Signalregulatory protein alpha-2, Sirp-alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-3, p84, CD172a, BIT, MFR.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174221250644,"sku":"PRO-2755","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174221283412,"sku":"PRO-2755","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174221316180,"sku":"PRO-2755","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cd172a-human-PRO-2755.png?v=1776440876"},{"product_id":"sirpa-rat","title":"SIRPA Rat","description":"\u003cp\u003eSignal-Regulatory Protein Alpha Rat Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eTyrosine-protein\nphosphatase non-receptor type substrate 1, SHP substrate, SHPS-1, Brain Ig-like\nmolecule with tyrosine-based activation motifs, Bit, CD172 antigen-like\nfamily member A, Inhibitory receptor\nSHPS-1, Macrophage fusion receptor, Macrophage membrane protein MFP150, Signal-regulatory\nprotein alpha-1, Sirp-alpha-1, CD172a, Sirpa, Bit, Mfr, Ptpns1, Shps1, Sirp.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174222233684,"sku":"PRO-2258","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174222266452,"sku":"PRO-2258","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174222299220,"sku":"PRO-2258","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sirpa-rat-PRO-2258.png?v=1776445934"},{"product_id":"sirpb1-human","title":"SIRPB1 Human","description":"\u003cp\u003eRecombinant Human Signal Regulatory Protein Beta 1\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSIRPB1, CD172b, SIRP-BETA-1, SIRP-Beta-1 Isoform 3, CD172b Antigen, CD172b.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174222954580,"sku":"PRO-2545","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174222987348,"sku":"PRO-2545","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174223020116,"sku":"PRO-2545","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sirpb1-human-PRO-2545.png?v=1776445940"},{"product_id":"sirpg-human-sf9","title":"SIRPG  Human, Sf9","description":"\u003cp\u003eSignal-Regulatory Protein Gamma Human Recombinant, Sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSignal Regulatory Protein Gamma, CD172 Antigen-Like Family Member B, Signal-Regulatory Protein Beta-2, Signal-Regulatory Protein Gamma, CD172g Antigen, SIRP-Gamma, SIRP-B2, SIRPB2, Signal-Regulatory Protein Beta 2, SIRP-Beta-2, SIRP Beta 2, SIRPgamma, BA77C3.1, CD172g.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174224003156,"sku":"PRO-2435","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174224035924,"sku":"PRO-2435","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174224068692,"sku":"PRO-2435","price":3800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sirpg-human-sf9-PRO-2435.png?v=1776445946"},{"product_id":"sirpg-human","title":"SIRPG Human","description":"\u003cp\u003eSignal-Regulatory Protein Gamma Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003esignal-regulatory protein gamma isoform 1 precursor, bA77C3.1, CD172g, SIRP-B2, SIRPB2, SIRPgamma, Signal-Regulatory Protein Gamma, SIRPG, SIRP-b2, SIRP-beta-2, CD_antigen: CD172g, CD172 antigen-like family member B, Signal-regulatory protein beta-2, SIRP-gamma.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174224953428,"sku":"PRO-2013","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174224986196,"sku":"PRO-2013","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174225018964,"sku":"PRO-2013","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sirpg-human-PRO-2013.png?v=1776710197"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_72760592-e220-454b-a6da-2c3175c6098f.png?v=1700647887","url":"https:\/\/prospecbio.com\/collections\/signal-regulatory-protein.oembed","provider":"prospecbio","version":"1.0","type":"link"}