{"title":"SIGLEC","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SIGLEC:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSialic acid-binding immunoglobulin-type lectins, perhaps best known as SIGLECs, are surface-level proteins responsible for multiple interactions. They primarily oversee sialic acid binding. Usually, they can be seen on an immune cell’s surface. These proteins are a subcategory of I-type lectins, where there being numerous different types.\u003cbr data-mce-fragment=\"1\"\u003eThese different types oversee and are involved in quite a few functions. Cell surface receptor-ligand interactions will be the main factor in determining exactly what these SIGLECs are used for.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSIGLEC Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eEvery SIGLEC has what’s known as an N-terminal V-type immunoglobulin domain. That’s responsible for ensuring adhesion and proper binding with sialic acid. On the protein’s surface, there are C2-type Ig domains, which extend beyond the protein itself. These don’t have any binding qualities, however.\u003cbr data-mce-fragment=\"1\"\u003eThe proteins also include Immunoreceptor tyrosine-based inhibitory motifs, with these contained in their cytosolic region.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSIGLEC Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eA SIGLEC’s primary function is to bind sialic acid. That interaction can be seen in multiple processes, including cell signalling and adhesion. They are, however, limited to cell distribution, making their versatility and overall use relatively restricted.\u003cbr data-mce-fragment=\"1\"\u003eBecause most of these proteins are short, their activity is restricted to the surface of cells. That also means that they can’t bind to cells other than sialic acid. That’s primarily due to mammalian cells, which typically include sialic acid-containing glycans.\u003cbr data-mce-fragment=\"1\"\u003eAs a result, the protein can only bind to the surface of these cells without being able to penetrate deeper. There are some minor exceptions, however. The most notable is Sialoadhesin. This chemical has a long, extended protein, which can aid with further interactions with the protein.\u003c\/p\u003e","products":[{"product_id":"siglec10-human","title":"SIGLEC10 Human","description":"\u003cp\u003eSialic Acid Binding Ig Like Lectin 10 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSIGLEC10, PRO940, SLG2, SIGLEC-10, Sialic acid-binding Ig-like lectin 10 isoform 3, Siglec-like protein 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Ig-Like Lectin 5, CD170 Antigen, CD170, Sialic acid-binding Ig-like lectin 5, Siglec-5, CD33 antigen-like 2, Obesity-binding protein 2, OB-BP2, OB-binding protein 2, CD170.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174210764884,"sku":"PRO-2432","price":50.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174210797652,"sku":"PRO-2432","price":130.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174210830420,"sku":"PRO-2432","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-siglec5-human-PRO-2432.png?v=1776710187"},{"product_id":"siglec6-human","title":"SIGLEC6 Human","description":"\u003cp\u003eSialic Acid Binding Ig Like Lectin 6 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSialic Acid Binding Ig Like Lectin 6, Obesity-Binding Protein 1, CD33 Antigen-Like 1, CDW327, CD33L1, CD33L, OBBP1, Sialic Acid Binding Ig-Like Lectin 6, Sialic Acid-Binding Ig-Like Lectin 6, CD327 Antigen, Siglec-6, CD33L2, OB-BP1, CD327, SIGLEC6.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174211616852,"sku":"PRO-2450","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174211649620,"sku":"PRO-2450","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174211682388,"sku":"PRO-2450","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-siglec6-human-PRO-2450.png?v=1776445903"},{"product_id":"siglec7-human","title":"SIGLEC7 Human","description":"\u003cp\u003eSialic Acid Binding Ig Like Lectin 7 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSialic Acid Binding Ig Like Lectin 7, QA79 Membrane Protein, SIGLEC-7, D-Siglec, AIRM-1, CDw328, AIRM1, P75, Sialic Acid Binding Ig-Like Lectin 19, Pseudogene, Adhesion Inhibitory Receptor Molecule 1, Siglec-7, Sialic Acid Binding Ig-Like Lectin, Pseudogene 2, Sialic Acid Binding Immunoglobulin-Like Lectin 7, Adhesion Inhibitory Receptor Molecule 1, Sialic Acid Binding Ig-Like Lectin 7, Sialic Acid-Binding Ig-Like Lectin 7, CD328 Antigen, SIGLEC19P, P75\/AIRM1, SIGLECP2, CD328, QA79.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174212370516,"sku":"PRO-2458","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174212403284,"sku":"PRO-2458","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174212436052,"sku":"PRO-2458","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-siglec7-human-PRO-2458.png?v=1776445909"},{"product_id":"siglec9-human","title":"SIGLEC9  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