{"title":"SH2 Domain","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SH2D1 \/ SH2 Domain Protein:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eA protein usually found within the Src oncoprotein, Src Homology 2 is a conserved protein domain. While it’s primarily seen in the Src oncoprotein, it also turns up in some specific intracellular signal-transducing proteins. Finding it outside of these is rare, and they shouldn’t be found outside the adaptor proteins.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSH2D1 Binding\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSH2 domains are only know to bind phosphorylated tyrosine residue, although this is typically if a target protein with a longer peptide motif. Out of the currently known pTyr-recognition domains, that makes SH2 the largest one to behave in such a way.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSH2 Domain Protein Diversity\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe prominence of SH2 domains isn’t too diverse. While they don’t turn up in yeast and things of a similar makeup, they can be found in the boundary between animalia and protozoa. It can also be found in Dictyostelium discoideum.\u003cbr data-mce-fragment=\"1\"\u003eWithin the human body, studies have shown that there are 120 domains across 115 proteins in the human genome. That highlights a rapid rate of expansion across the domains.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSH2D1 Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSH2 domains focus on recognizing tyrosine residues’ phosphorylated state. In doing so, it allows for the localization of these sites. There are multiple reactions involved in this process, such as sending a signal through membranes, which are then “sensed” by receptors. These will then result in other actions that focus on activating and localizing the site.\u003cbr data-mce-fragment=\"1\"\u003eOnce the process is completed, gene expressions and other responses should have altered patterns. In essence, the SH2 domain can be seen as a regulatory module that focuses on intracellular signalling cascades.\u003cbr data-mce-fragment=\"1\"\u003eIt typically interacts well with target peptides that contain high volumes of phosphotyrosine.\u003c\/p\u003e","products":[{"product_id":"sh2d1a-human","title":"SH2D1A Human","description":"\u003cp\u003eSH2 domain containing 1A Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSH2 domain-containing protein 1A, Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP, SH2D1A, DSHP, SAP, LYP, XLP, EBVS, IMD5, XLPD, MTCP1, FLJ18687, FLJ92177, SAP\/SH2D1A.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174184124500,"sku":"PRO-006","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174184157268,"sku":"PRO-006","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174184190036,"sku":"PRO-006","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sh2d1a-human-PRO-006.png?v=1776710140"},{"product_id":"sh2d1b-human","title":"SH2D1B Human","description":"\u003cp\u003eSH2 domain containing 1B Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSH2 Domain Containing 1B, EWS\/FLI1-Activated Transcript 2, EAT-2, EAT2, SH2 Domain-Containing Molecule EAT2, SH2 Domain-Containing Protein 1B, SH2 domain-containing protein 1B, EWS\/FLI1-activated transcript 2, EAT-2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174185009236,"sku":"PRO-2470","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174185042004,"sku":"PRO-2470","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174185074772,"sku":"PRO-2470","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sh2d1b-human-PRO-2470.png?v=1776445813"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_8f5783be-c62b-49fc-8856-1dd472c9c29c.png?v=1700647881","url":"https:\/\/prospecbio.com\/collections\/sh2-domain.oembed","provider":"prospecbio","version":"1.0","type":"link"}