{"title":"Serpin","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout Serpin:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSerpin is the name given to a superfamily of proteins that all share a similar structure. These are found in virtually all forms of life and are known for their protease inhibition activities. These irreversible activities lead to a conformational change in its target site.\u003cbr data-mce-fragment=\"1\"\u003eA Serpin’s protease inhibition is involved in a range of biological processes, such as inflammation and coagulation. Typically, the inhibition will control these processes, which has led to the proteins being the focus of extensive research.\u003cbr data-mce-fragment=\"1\"\u003eMost of these proteins control proteolytic cascades, although some don't. Instead, some perform storage, among other duties.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSerpin Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eWhile Serpins all have different functions, they share the same basic structure. They each have three β-sheets, alongside either eight or nine α-helices. The most prominent parts of the structure are its A sheet and its reactive centre loop.\u003cbr data-mce-fragment=\"1\"\u003eThat’s driven by the A sheet’s dual β-strands, alongside the RCL’s initial interaction with the target protease.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSerpin Function \u0026amp; Localization\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe majority of Serpins focus on extracellular roles. They are, for example, responsible for tissue remodelling and inflammatory and immune responses in the bloodstream. By inhibiting certain proteases, they can also affect development.\u003cbr data-mce-fragment=\"1\"\u003eThe exact target and function of these intracellular processes can be difficult to determine, as some molecules often have overlapping duties. Typically, however, they protect against any inappropriate proteases within the cell.\u003cbr data-mce-fragment=\"1\"\u003eSerpins can also perform a range of non-inhibitory roles. These include the transport of multiple other hormones and molecules, such as cortisol and thyroxine. These roles can often differ from species to species, with birds often seeing slightly different effects than humans.\u003c\/p\u003e","products":[{"product_id":"serpina1-human","title":"SERPINA1","description":"\u003cp\u003eAlpha 1 Antitrypsin Human\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eAlpha-1-antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, SERPINA1, A1AT, PI, A1A, AAT, PI1, MGC9222, PRO2275, MGC23330.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"100µg","offer_id":43174126354516,"sku":"PRO-456","price":80.0,"currency_code":"USD","in_stock":true},{"title":"500µg","offer_id":43174126387284,"sku":"PRO-456","price":165.0,"currency_code":"USD","in_stock":true},{"title":"5mg","offer_id":43174126420052,"sku":"PRO-456","price":1430.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-serpina1-human-PRO-456.png?v=1776445637"},{"product_id":"serpina1-human-recombinant","title":"SERPINA1 Human","description":"\u003cp\u003eAlpha 1 Antitrypsin Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eAlpha-1-antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, SERPINA1, A1AT, PI, A1A, AAT, PI1, MGC9222, PRO2275, 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MGC23330.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"20µg","offer_id":43174128648276,"sku":"PRO-907","price":60.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174128681044,"sku":"PRO-907","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174128713812,"sku":"PRO-907","price":1050.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-serpina1-human-active-PRO-907.png?v=1776445632"},{"product_id":"serpina3-human-recombinant","title":"SERPINA3","description":"\u003cp\u003eAlpha-1 AntiChymotrypsin Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eAlpha-1-antichymotrypsin, ACT, Cell growth-inhibiting gene 24\/25 protein, SERPINA3, AACT, A1ACT, GIG24, GIG25, MGC88254.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174129827924,"sku":"PRO-750","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174129860692,"sku":"PRO-750","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174129893460,"sku":"PRO-750","price":2250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-serpina3-human-recombinant-PRO-750.png?v=1776445650"},{"product_id":"serpina3-human","title":"SERPINA3 Human","description":"\u003cp\u003eAlpha-1 AntiChymotrypsin Human\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eAlpha-1-antichymotrypsin, ACT, Cell growth-inhibiting gene 24\/25 protein, SERPINA3, AACT, A1ACT, GIG24, GIG25, MGC88254.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"20µg","offer_id":43174130909268,"sku":"PRO-378","price":60.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174130942036,"sku":"PRO-378","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174130974804,"sku":"PRO-378","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-serpina3-human-PRO-378.png?v=1776445645"},{"product_id":"serpina4-human","title":"SERPINA4 Human","description":"\u003cp\u003eKallistatin Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSerpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin) Member 4, PI4, KST, Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4, Peptidase Inhibitor 4, Kallikrein Inhibitor, Serpin A4, PI-4, Protease Inhibitor 4 (Kallistatin), Kallistatin, KLST, KAL, SERPINA4.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174131826772,"sku":"PRO-2036","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174131859540,"sku":"PRO-2036","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174131892308,"sku":"PRO-2036","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-serpina4-human-PRO-2036.png?v=1776445654"},{"product_id":"serpina5-human","title":"SERPINA5 Human","description":"\u003cp\u003eSerpin Peptidase Inhibitor Clade A Member 5 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003ePAI3, PCI, PROCI, PLANH3, Protein-C Inhibitor, Serpin A5, Plasminogen activator inhibitor 3, PAI-3, SERPINA5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174132908116,"sku":"PRO-749","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174132940884,"sku":"PRO-749","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174132973652,"sku":"PRO-749","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-serpina5-human-PRO-749.png?v=1776445659"},{"product_id":"serpina5-protein","title":"SERPINA5 Human, Active","description":"\u003cp\u003eSerpin Peptidase Inhibitor, Clade A Member 5 Human Recombinant, Active\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSerpin Family A Member 5, Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5, Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5, Acrosomal Serine Protease Inhibitor 3 4 Protein C Inhibitor, PLANH3, PAI-3, PROCI, PAI3, PCI, Plasminogen Activator Inhibitor III, Plasminogen Activator Inhibitor-3, Plasminogen Activator Inhibitor 3, Plasma Serine Protease Inhibitor, Serpin A5, PCI-B.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174133891156,"sku":"PRO-2523","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174133923924,"sku":"PRO-2523","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174133956692,"sku":"PRO-2523","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-serpina5-protein-PRO-2523.png?v=1776445664"},{"product_id":"serpina7-human","title":"SERPINA7 Human","description":"\u003cp\u003eSerpin Peptidase Inhibitor, Clade A Member 7 Human\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"0.2mg","offer_id":43174137200724,"sku":"PRO-2739","price":385.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174137233492,"sku":"PRO-2739","price":990.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":43174137266260,"sku":"PRO-2739","price":3850.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-serpina7-human-PRO-2739.png?v=1776710068"},{"product_id":"serpina8-human","title":"SERPINA8 Human","description":"\u003cp\u003eSerpin Peptidase Inhibitor, Clade A Member 8 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eAngiotensinogen, Serpin A8, AGT, SERPINA8, ANHU.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174138118228,"sku":"PRO-1572","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174138150996,"sku":"PRO-1572","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174138183764,"sku":"PRO-1572","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-serpina8-human-PRO-1572.png?v=1776445668"},{"product_id":"serpina9-mouse","title":"SERPINA9 Mouse","description":"\u003cp\u003eSerpin Peptidase Inhibitor, Clade A  Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSerpin A9, Serpina9, SERPINA9.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174138970196,"sku":"PRO-2366","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174139002964,"sku":"PRO-2366","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174139035732,"sku":"PRO-2366","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-serpina9-mouse-PRO-2366.png?v=1776445672"},{"product_id":"serpinb2-human","title":"SERPINB2 Human","description":"\u003cp\u003eSerpin Peptidase Inhibitor, Clade B Member 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSerpin Peptidase Inhibitor Clade B (Ovalbumin) Member 2, Serine (Or Cysteine) Proteinase Inhibitor Clade B (Ovalbumin) Member 2, Placental Plasminogen Activator Inhibitor, Plasminogen Activator Inhibitor Type II (Arginine-Serpin), PAI2, PLANH2, Monocyte Arg-Serpin, Serpin B2, HsT1201, PAI.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174139822164,"sku":"PRO-1788","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174139854932,"sku":"PRO-1788","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174139887700,"sku":"PRO-1788","price":4680.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-serpinb2-human-PRO-1788.png?v=1776445681"},{"product_id":"serpinb2-human-his","title":"SERPINB2 Human, His","description":"\u003cp\u003eSerpin Peptidase Inhibitor, Clade B Member 2 Human Recombinant, His Tag\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003ePlasminogen activator inhibitor 2, PAI-2, Plasminogen activator inhibitor 2, SERPINB2, Serpin Peptidase Inhibitor, Clade B Member 2, His Tag, PLANH2, Monocyte Arg-serpin, 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