{"title":"Serine Peptidase Inhibitor","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SPIN \/ Serine Peptidase Inhibitor:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSerine peptidase inhibitor, also known as SPIN, encoded by the SPINT2 gene, and also called Kunitz-type protease inhibitor 2, is an enzyme inhibitor.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSPIN Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSPIN is a transmembrane protein, meaning it spans the entirety of the cell membrane, acting as gateways to inhibit the movement of serine proteases. Serine proteases cleave peptide bonds in proteins. As such, SPIN may act as a tumor suppressor, preventing the passages of HGF activator which, in turn, prevents the formation of hepatocyte growth factor, which is secreted by mesenchymal cells and targets epithelial cells, endothelial cells, hemopoietic progenitor cells, and T cells.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSerine Peptidase Inhibitor Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSPIN mechanisms have been observed in suppressing OSCC cell migration and invasion, where it was seen that it contains gelatinolytic bands sensitive to GM6001, suggesting the presence of pro-matrix metalloprotease (MMP)-2 and -9. There is also evidence that the primary target protease for HAI-2 in the epithelial cell is prostasin.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSPIN Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSPIN interacts with a range of other proteins, including AP5M1 AP-5 complex subunit mu-1 ), PRSS3 (Serine Protease 3), C19orf33 (Chromosome 19 Open Reading Frame 33), SLC26A3 (Solute Carrier Family 26 Member 3), EPCAM (Epithelial Cell Adhesion Molecule), MYO5B (Myosin VB), PRSS8 (Serine Protease 8), ST14 (ST14 Transmembrane Serine Protease Matriptase), and MST1 (Macrophage Stimulating 1) .\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSerine Peptidase Inhibitor Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSPIN has a size of 252 amino acids and a molecular mass of 28228 Da.\u003c\/p\u003e","products":[{"product_id":"spink7-human","title":"SPINK7 Human","description":"\u003cp\u003eSerine Peptidase Inhibitor Kazal Type 7 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSerine peptidase inhibitor Kazal type 7, ECG2, ECRG2, Serine protease inhibitor Kazal-type 7, Esophagus cancer-related gene 2 protein, ECRG-2, SPINK7.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174355238996,"sku":"PRO-1507","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174355271764,"sku":"PRO-1507","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174355304532,"sku":"PRO-1507","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-spink7-human-PRO-1507.png?v=1776710800"},{"product_id":"spint2-human","title":"SPINT2 Human","description":"\u003cp\u003eSerine Peptidase Inhibitor, Kunitz Type 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eDIAR3, FLJ45571, HAI-2, HAI2, Kop, PB, Kunitz-type protease inhibitor 2, Hepatocyte growth factor activator inhibitor type 2, Placental bikunin, SPINT2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174356058196,"sku":"PRO-1296","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174356090964,"sku":"PRO-1296","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174356123732,"sku":"PRO-1296","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-spint2-human-PRO-1296.png?v=1776710804"},{"product_id":"spint2-human-sf9","title":"SPINT2 Human, Sf9","description":"\u003cp\u003eSerine Peptidase Inhibitor, Kunitz Type 2 Human Recombinant, Sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSerine Peptidase Inhibitor, Kunitz Type, 2, Placental\nBikunin, Hepatocyte Growth Factor Activator Inhibitor Type 2, Serine Protease\nInhibitor, Kunitz Type, 2, HAI-2, HAI2, Kop, Kunitz-Type Protease Inhibitor 2, Placental,\nBikunin, DIAR3, PB, Kunitz-type protease inhibitor 2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174356975700,"sku":"PRO-2219","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174357008468,"sku":"PRO-2219","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174357041236,"sku":"PRO-2219","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-spint2-human-sf9-PRO-2219.png?v=1776710809"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_6d2538e2-aa37-4536-a1df-546e0b230742.png?v=1700647906","url":"https:\/\/prospecbio.com\/collections\/serine-peptidase-inhibitor.oembed","provider":"prospecbio","version":"1.0","type":"link"}