{"title":"Serglycin","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SRGN \/ Serglycin:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSerglycin is a protein found in humans that is encoded by the SRNG gene, and is also known as SRNG for short. It is also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSRGN Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe primary function of this gene is to encode the protein known as a hematopoietic cell granule proteoglycan. These glycosylated proteins are contained in hematopoietic cells, stem cells that give rise to other blood cells through hematopoiesis. Their purpose in these cells may be to neutralize hydrolytic enzymes.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSerglycin Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe specifics of the exact molecular mechanism of serglycin are unclear at the current time of writing. It is known that serglycin secretory mechanisms show that it is secreted in monocytes or macrophages, myeloma cells, and human endothelial cells and that it is stored in secretory granules and secreted after cells activation in neutrophils and mast cells.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSRGN Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSerglycin interacts with different compounds depending on which cells they were in. In mast cells, they interact with carboxypeptidase, chymase, histamine, and trypaste. In neutrophils, they interact with elasatae. In cytotoxic T cells, they interact with granzyme B. In endothelial cells, they react with tissue-type plasminogen activators. Lastly, in macrophages, they interact with tumor necrosis factor-alpha.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSerglycin Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSerglycin is currently the only known intracellular proteoglycan. It is located in chromosome 10q.22.1 in humans, and consists of 1.b kb of 5’-flanking DNA and three exons.\u003c\/p\u003e","products":[{"product_id":"srgn-human","title":"SRGN Human","description":"\u003cp\u003eSerglycin Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSerglycin, PRG, PRG1, PPG, Proteoglycan 1 secretory granule, Hematopoetic proteoglycan core protein, Platelet proteoglycan core protein, proteoglycan protein core for mast cell secretory granule.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174384894036,"sku":"PRO-965","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174384926804,"sku":"PRO-965","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174384959572,"sku":"PRO-965","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-srgn-human-PRO-965.png?v=1776710909"},{"product_id":"srgn-human-hek","title":"SRGN Human, HEK","description":"\u003cp\u003eSerglycin Human Recombinant, HEK\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSerglycin, PRG, PRG1, PPG, Proteoglycan 1 secretory granule, Hematopoetic proteoglycan core protein, Platelet proteoglycan core protein, proteoglycan protein core for mast cell secretory granule.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174385778772,"sku":"PRO-2046","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174385811540,"sku":"PRO-2046","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174385844308,"sku":"PRO-2046","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-srgn-human-hek-PRO-2046.png?v=1776710904"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_5e1141c9-8706-4899-88eb-6c2a7c93787e.png?v=1700647910","url":"https:\/\/prospecbio.com\/collections\/serglycin.oembed","provider":"prospecbio","version":"1.0","type":"link"}