{"title":"Secreted Frizzled-Related Protein","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SFRP \/ Secreted Frizzled-Related Protein:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSecreted Frizzled-Related Protein is a family of proteins that contain two main proteins: SFRP2 and SFRP4. Both SFRP2 and SFRP4 have a multitude of aliases, the ones for secreted frizzle-related protein 2 are as follows: FRP-2, SARP1, and SDF-5. For secreted frizzled-related protein 4, the aliases are FRP-4, FRPHE, sFRP-4, PYL, and FRZB-2.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSFRP Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThis family consists of a cysteine-rich domain homologous to the putative Wnt-binding site of the Frizzled proteins.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSecreted Frizzled-Related Protein Function \u0026amp; Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe SFRP family is believed to act as soluble modulators of the Wnt signaling process. Methylation of this dene is also linked to colorectal cancer. Specifically, studies show that this can be a potential marker for the presence of this cancer.\u003cbr data-mce-fragment=\"1\"\u003eSFRP2 gene is very commonly detected in an overexpressed state in human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. Consequently, this protein has a high chance of being associated with tumorigenesis.\u003cbr data-mce-fragment=\"1\"\u003eSFRP4 is expressed in the ventricular myocardium and is a hub gene in a type 2 diabetes-associated gene co-expression module in human islets. Studies show that one of its functions is to decrease B-cell exocytosis, which reduces glucose-induced insulation secretion. Further research has also indicated that SFRP4 is elevated several years before people have been diagnosed with Type 2 Diabetes. People with higher-than-average levels of SFRP4 in their blood are shown to be five times more likely to develop diabetes than those with normal or below-average levels. Furthermore, the concentration of this protein is also deemed to correlate with obesity and systemic insulin resistance.\u003c\/p\u003e","products":[{"product_id":"sfrp2-human","title":"SFRP2 Human","description":"\u003cp\u003eSecreted Frizzled-Related Protein 2  Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eFRP-2, SARP1, SDF-5, Secreted frizzled-related protein 2,\nUNQ361\/PRO697, FKSG12, FKSG12.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174170198100,"sku":"PRO-1905","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174170230868,"sku":"PRO-1905","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174170263636,"sku":"PRO-1905","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sfrp2-human-PRO-1905.png?v=1776445776"},{"product_id":"sfrp2-mouse","title":"SFRP2 Mouse","description":"\u003cp\u003eSecreted Frizzled-Related Protein 2 Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSecreted frizzled-related protein 2, sFRP-2, sFRP2, Sfrp2, Protein SDF5, Sdf5, AI851596, sdf, SDF-5, FRP2secreted apoptosis related protein 1, Secreted apoptosis-related protein 1, SARP-1, Sarp1, SARP1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174171115604,"sku":"pro-2669","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174171148372,"sku":"pro-2669","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174171181140,"sku":"pro-2669","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/product_image.jpg?v=1772485009"},{"product_id":"sfrp4-human-sf9","title":"SFRP4  Human, sf9","description":"\u003cp\u003eSecreted Frizzled-Related Protein 4 Human Recombinant, sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSecreted Frizzled Related Protein 4, Secreted\nFrizzled-Related Protein 4, Frizzled Protein, Human Endometrium, SFRP-4, FRPHE\nSecreted Frizzled-Related Protein 4; Secreted Frizzled-Related Protein 4,\nFRP-4, PYL, SFRP4, FRPHE.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174172065876,"sku":"PRO-2368","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174172098644,"sku":"PRO-2368","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174172131412,"sku":"PRO-2368","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sfrp4-human-sf9-PRO-2368.png?v=1776445786"},{"product_id":"sfrp4-human","title":"SFRP4 Human","description":"\u003cp\u003eSecreted Frizzled-Related Protein 4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSecreted frizzled-related protein 4, sFRP-4, Frizzled protein, human endometrium, FrpHE, SFRP4, FRPHE, FRP-4.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174173540436,"sku":"PRO-1604","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174173573204,"sku":"PRO-1604","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174173605972,"sku":"PRO-1604","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sfrp4-human-PRO-1604.png?v=1776445781"},{"product_id":"sfrp5-human","title":"SFRP5 Human","description":"\u003cp\u003eSecreted Frizzled-Related Protein 5 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSecreted Frizzled-Related Protein 5, SARP3, Secreted Apoptosis Related Protein 3, Secreted Apoptosis-Related Protein 3, Frizzled-Related Protein 1b, FRP-1b, SARP-3, SFRP-5, FRP1B, SFRP5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174174457940,"sku":"PRO-2171","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174174490708,"sku":"PRO-2171","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174174523476,"sku":"PRO-2171","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sfrp5-human-PRO-2171.png?v=1776710117"},{"product_id":"fzd10-human","title":"FZD10 Human","description":"\u003cp\u003eFrizzled Class Receptor 10 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eFZ-10, CD350, Fz10, FzE7, frizzled-10, hFz10, FZD10, frizzled class receptor 10.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174760153172,"sku":"PRO-2819","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174760185940,"sku":"PRO-2819","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174760218708,"sku":"PRO-2819","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fzd10-human-PRO-2819.png?v=1776694701"},{"product_id":"fzd4-human","title":"FZD4 Human","description":"\u003cp\u003eFrizzled Class Receptor 4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eFrizzled-4, Fz-4, hFz4, FzE4, CD344, FZD4.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174761136212,"sku":"PRO-2464","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174761168980,"sku":"PRO-2464","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174761201748,"sku":"PRO-2464","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fzd4-human-PRO-2464.png?v=1776694705"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_22f696c2-400d-44f8-94f8-557a45fcad67.png?v=1700647447","url":"https:\/\/prospecbio.com\/collections\/secreted-frizzled-related-protein.oembed","provider":"prospecbio","version":"1.0","type":"link"}