{"title":"Secretagogin","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SCGN \/ Secretagogin:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSecretagogin is found in humans and is a protein that's encoded by the SCGN gene. It has numerous aliases, including the following: CALBL, DJ501N12.8, EF-hand calcium-binding protein, setagin, SECRET, and SEGN.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSCGN Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSecretagogin is a Hexa-EF-hand protein that is most commonly expressed in the pancreas, brain, and gastrointestinal tract. It presents a crystal structure with a SNAP-25 fragment that shows the SNAP-25 adopts a helical structure and binds to EF-hands 5 and 6 of SCGN. It possesses six EF-hand helix-loop-helix calcium-binding motifs. Originally, this protein was cloned from pancreatic B cells.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSecretagogin Function \u0026amp; Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThis is an encoded protein that is found in the cytoplasm and is secreted with calcium-binding properties. Calretinin and calbindin D-28K are both relatives of secretagogin. It is believed that this protein is involved in the potassium chloride-stimulated calcium flux, along with cell proliferation. Cell proliferation is the process in which a cell grows and starts dividing to produce daughter cells. In turn, this leads to a massive increase in cell number and is one of the fastest mechanisms for tissue growth.\u003cbr data-mce-fragment=\"1\"\u003eIt has also been discovered through various forms of research that secretagogin plays a crucial role in releasing stress hormones. The specific stress hormone in question is corticotropin-releasing hormone - CRH - which will then enable stress processes in the brain. Tests have been conducted on zebrafish that show that the interaction between SCGN and SNAP-25\/SNAP-23 has been shown to be critical for neuronal growth and brain development in the fish.\u003c\/p\u003e","products":[{"product_id":"scgn-human","title":"SCGN Human","description":"\u003cp\u003eSecretagogin Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSCGN, EF-hand calcium binding protein, Setagin, SEGN, CALBL, SECRET, DJ501N12.8, Secretagogin.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174071337044,"sku":"PRO-599","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174071369812,"sku":"PRO-599","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174071402580,"sku":"PRO-599","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-scgn-human-PRO-599.png?v=1776445437"},{"product_id":"scgn-rat","title":"SCGN Rat","description":"\u003cp\u003eSecretagogin Rat Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSCGN, EF-hand calcium binding protein, Setagin, SEGN, CALBL, Secretagogin.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174072156244,"sku":"PRO-657","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174072189012,"sku":"PRO-657","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174072221780,"sku":"PRO-657","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-scgn-rat-PRO-657.png?v=1776445442"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_6228fb0a-c617-4f40-bcb1-5ebd38ac75da.png?v=1700647867","url":"https:\/\/prospecbio.com\/collections\/secretagogin.oembed","provider":"prospecbio","version":"1.0","type":"link"}