{"title":"Sclerostin","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout SOST \/ Sclerostin:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eSclerostin is a protein in humans that is encoded by the SOST gene. It is also identified by the following aliases: CDD, SOST1, VBCH, and DAND6. It is a glycoprotein that's secreted in the body and has a C-terminal cysteine knot-like domain. Its sequence can be compared to that of the DAN family of bone morphogenetic protein antagonists. More often than not, this protein is produced by the osteocyte, though it is found in other tissues as well.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSOST Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eSOST has a length of 213 residues and a secondary structure that has been determined by protein NMR. It is a 28% beta-sheet, with 6 stands and 32 residues. This protein is the product of the SOST gene and is found on chromosome 17q12-q21 in humans.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSclerostin Functions \u0026amp; Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eInitially, sclerostin was thought to be a non-classical bone morphogenetic protein (BMP) antagonist. However, more recent data and studies have concluded that this protein binds to LRP5\/6 receptors and inhibits the Wnt signaling pathway. As a consequence, this leads to decreased bone formation.\u003cbr data-mce-fragment=\"1\"\u003eIt is currently unclear on the precise mechanisms that are responsible for this function, but many experts believe that the antagonism of BMP-induced bone formation by sclerostin is mediated by Wnt signaling, rather than BMP signaling pathways.\u003cbr data-mce-fragment=\"1\"\u003eSclerostin is mainly expressed in osteocytes and some chondrocytes, preventing bone formation by osteoblasts. Often, the production of this protein by osteocytes is inhibited by parathyroid hormone, mechanical loading, estrogen, and various cytokines. On the other hand, the production of this protein is increased by calcitonin.\u003c\/p\u003e","products":[{"product_id":"sost-human","title":"SOST Human","description":"\u003cp\u003eSclerostin Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSclerostin, SOST, CDD, VBCH.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174325878868,"sku":"PRO-1601","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174325911636,"sku":"PRO-1601","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174325944404,"sku":"PRO-1601","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sost-human-PRO-1601.png?v=1776710674"},{"product_id":"sost-protein","title":"SOST Human, HEK","description":"\u003cp\u003eSclerostin Human Recombinant, HEK\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSclerostin, SOST, CDD, VBCH.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174327484500,"sku":"PRO-2481","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174327517268,"sku":"PRO-2481","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174327550036,"sku":"PRO-2481","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sost-protein-PRO-2481.png?v=1776710678"},{"product_id":"sostdc1-human","title":"SOSTDC1 Human","description":"\u003cp\u003eSclerostin Domain Containing 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSclerostin domain-containing protein 1, Ectodermal BMP inhibitor, Ectodin, Uterine sensitization-associated gene 1 protein, USAG-1, SOSTDC1, USAG1, CDA019.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174329319508,"sku":"PRO-426","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174329352276,"sku":"PRO-426","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174329385044,"sku":"PRO-426","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-sostdc1-human-PRO-426.png?v=1776710683"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_2395c3d2-60d9-4b0a-8190-352e4a844dc8.png?v=1700647900","url":"https:\/\/prospecbio.com\/collections\/sclerostin.oembed","provider":"prospecbio","version":"1.0","type":"link"}