{"title":"Rho GDP Dissociation Inhibitor","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout ARHGDI \/ Rho GDP Dissociation Inhibitor:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe Rho GDP Dissociation Inhibitor (ARHGDI) is a protein that regulates the actin cytoskeleton. This protein binds to the GTP-bound form of Rho and prevents activation of Rac1 by dissociating it from its activators. ARHGDI functions as a molecular brake on Rac1 activation and can regulate:\u003cbr data-mce-fragment=\"1\"\u003e●Cell adhesion\u003cbr data-mce-fragment=\"1\"\u003e●Migration, and\u003cbr data-mce-fragment=\"1\"\u003e●Invasion through these mechanisms.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eARHGDI Mechanism of Action\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThis protein is a molecular brake that regulates the activation of Rac. ARHGDI binds to the GTP-bound form of Rho and prevents activation by dissociating it from its activators: PAK kinase or PIPKIα\/β complexes. This interaction with activated Rho disrupts the membrane localization of PAK, which in turn prevents its activation by PAK kinase.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eRho GDP Dissociation Inhibitor Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eARHGDI is a small monomer that has an N-terminal domain and a C-terminal stalk.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eARHGDI Cellular Location\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eIt associates with the cytoplasmic cell membranes, specifically at focal adhesions and regions of pseudopod extension from motile cells. The location where this protein localizes is crucial because it is at the cell adhesion and motility sites.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eSites in Which Arhgdi Regulates Rac Activation\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eFocal Adhesions - Focal adhesions are areas where integrins bind to extracellular proteins, such as fibronectin or laminins. Thus, the focal point of adhesion is where the cell binds to its substrate.\u003cbr data-mce-fragment=\"1\"\u003eRegions of Pseudopod Extension From Motile Cells- These regions on a moving cell contain focal adhesions and actin stress fibres that protrude out from the cellular body. These extensions are necessary because they are where new cell contacts with substrates usually form.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eRho GDP Dissociation Inhibitor Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eARHGDI interacts with the GTP-bound form of Rho, preventing activation by dissociating it from its activators.\u003cbr data-mce-fragment=\"1\"\u003eConclusively, the Rho GDP Dissociation Inhibitor (ARHGDI) is a protein that regulates Rac activation. Its localization sites are essential because it's at areas where new cell contacts with substrates usually form.\u003c\/p\u003e","products":[{"product_id":"arhgdia-human","title":"ARHGDIA Human","description":"\u003cp\u003eRho GDP dissociation inhibitor (GDI) alpha Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eRho GDP-dissociation inhibitor 1, Rho GDI 1, Rho-GDI alpha, ARHGDIA, GDIA1, RHOGDI, RHOGDI-1, MGC117248.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174227640404,"sku":"PRO-002","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174227673172,"sku":"PRO-002","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174227705940,"sku":"PRO-002","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-arhgdia-human-PRO-002.png?v=1776676856"},{"product_id":"arhgdib-human","title":"ARHGDIB Human","description":"\u003cp\u003eRho GDP Dissociation Inhibitor (GDI) Beta Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eRho GDP dissociation inhibitor (GDI) beta, Rho GDI 2, Rho-GDI beta, GDIA2, GDID4, Ly-GDI, RAP1GN1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174228295764,"sku":"PRO-1067","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174228328532,"sku":"PRO-1067","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174228361300,"sku":"PRO-1067","price":1100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-arhgdib-human-PRO-1067.png?v=1776440826"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_082f6aaf-03ca-4d14-aa5f-fa4a1f645547.png?v=1700646375","url":"https:\/\/prospecbio.com\/collections\/rho-gdp-dissociation-inhibitor.oembed","provider":"prospecbio","version":"1.0","type":"link"}