{"title":"Rho Family GTPase","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout RND \/ Rho Family GTPase:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe Rho family of GTPases, also RND, is a group of regulatory proteins that coordinate the actin cytoskeleton. These proteins are involved in many processes, including:\u003cbr data-mce-fragment=\"1\"\u003e●Cell division\u003cbr data-mce-fragment=\"1\"\u003e●Muscle contraction.\u003cbr data-mce-fragment=\"1\"\u003e●Regulating the immune system.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eRND Mechanism of Action\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe mechanism of action for these proteins is not fully understood. However, they are known to activate the GTPase activity of actin. Actin polymerization and depolymerization regulate cellular functions such as endocytosis and cell locomotion. The Rho family members may facilitate the formation of stress fibers in stretched cells.\u003cbr data-mce-fragment=\"1\"\u003eRho GTPases regulate actin cytoskeleton dynamics indirectly. They activate the small guanosine triphosphatase Rac. The binding of Rho proteins with phospholipids may also play a role in regulating cell shape and adhesion.\u003cbr data-mce-fragment=\"1\"\u003eFinally, some family members can stimulate or inhibit actin polymerization, while others may activate or hinder the process.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eRho Family GTPase Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThere are 18 different members of the Rho family, which all have a very similar structure. The proteins consist of two domains: an amino-terminal domain and a carboxy-terminal GTPase domain.\u003cbr data-mce-fragment=\"1\"\u003eThe related protein Rac is composed only of one domain - it has no second C-terminus containing the autocatalytic GTPase domain. Instead, the amino-terminal domain binds to proteins and lipids, including membrane phospholipid PI(P) (phosphatidylinositol).\u003cbr data-mce-fragment=\"1\"\u003eThe carboxy terminus is a guanosine triphosphate binding site for guanine nucleotide exchange factors.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eRND Cellular Functions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eOne study showed that the RhoA protein is expressed at high levels in neutrophils and platelets, while other family members are on various cell types.\u003cbr data-mce-fragment=\"1\"\u003eChemotaxis - Cells stimulated by chemoattractants such as cytokines can respond with directional locomotion called chemotaxis. The activity of Rho GTPases regulates the directionality and speed of chemotaxis.\u003cbr data-mce-fragment=\"1\"\u003eConclusively, the Rho family of proteins are essential regulators for many cellular processes.\u003c\/p\u003e","products":[{"product_id":"rnd1-human","title":"RND1 Human","description":"\u003cp\u003eRho Family GTPase 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eRho family GTPase 1, GTP-binding protein, ras homolog gene family, member S, ARHS, RHOS, rho-related GTP-binding protein Rho6, RHO6, Rnd1, FLJ42294.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175334182996,"sku":"PRO-893","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175334215764,"sku":"PRO-893","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175334248532,"sku":"PRO-893","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-rnd1-human-PRO-893.png?v=1776709668"},{"product_id":"rnd3-human","title":"RND3 Human","description":"\u003cp\u003eRho Family GTPase 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eARHE, memB, Rho8, RhoE, Rho-related GTP-binding protein RhoE, Protein MemB, Rho family GTPase 3, Rho-related GTP-binding protein Rho8, Rnd3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175334871124,"sku":"PRO-487","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175334903892,"sku":"PRO-487","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175334936660,"sku":"PRO-487","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-rnd3-human-PRO-487.png?v=1776709675"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_a8aa71d0-f0c8-4ad6-9f3f-80d21f578722.png?v=1700647845","url":"https:\/\/prospecbio.com\/collections\/rho-family-gtpase.oembed","provider":"prospecbio","version":"1.0","type":"link"}