{"title":"Retinoblastoma","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout RBBP \/ Retinoblastoma:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eRetinoblastoma refers to a tumor that originates in the retina of a child's eye.\u003cbr data-mce-fragment=\"1\"\u003eIt is one form of cancer that develops when cells grow and multiply uncontrollably within a tissue, often leading to damage or changes in organs or tissues' normal anatomy and function. Notably, this condition affects activities such as eyesight.\u003cbr data-mce-fragment=\"1\"\u003eThe cause of retinoblastoma varies significantly across cases. Still, it can potentially result from; genetic mutations, exposure to radiation, infection with oncogenic viruses like HPV, genetics syndromes, pre-existing conditions including diabetes mellitus type II, and metabolic disorders, which may lead to hyperglycemia levels acting as an environmental risk factor for developing RBBP.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eRBBP Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eRetinoblastoma is cancer that affects the eye. It occurs when cells in the retina divide uncontrollably and form new, abnormal growths called retinoblasts (thus Retinoblastoma). Although there are many different types of Retinoblastomas, they all share one thing: uncontrolled cell division.\u003cbr data-mce-fragment=\"1\"\u003eA single gene mutation can be responsible for this change; some signs include defects in chromosomes 13 or 18. The cause of these mutations is still unknown, but it's believed that environmental influences may also play a role. This type of cancer can affect both eyes simultaneously or just one at a time, with an equal chance for either occurrence happening if only one parent has had RBBP previously diagnosed on them.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eRetinoblastoma Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe outer layer of the retina is made up of photoreceptors and nerve cells connected to the brain through optic nerves.\u003cbr data-mce-fragment=\"1\"\u003eThis structure allows our visual system to work by interpreting light, colour, shape, motion, depth, and other features to understand what we see around us at any given time. The inner layer of the eye consists mainly of blood vessels that supply oxygen-rich blood flow to various parts essential for sight, such as near-sightedness or farsightedness.\u003cbr data-mce-fragment=\"1\"\u003eUnderneath this vascular tissue sits a membrane called retinal pigment epithelium (RPE), where new rods and cones are formed constantly throughout life, with every part being renewed for about 100 days. This process happens so quickly because there's a constant supply of oxygen and nutrients from the blood vessels.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eRBBP Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eRetinoblastoma interacts with a lot of different tissues and cells in the body. One source, Genetic Disease Gene Database (GDD), cites that Retinoblastomas cause interactions between tumour cells and blood vessels by secreting substances like vascular endothelial growth factor A (VEGF-A). This interaction is required to grow new tumours that keep growing through angiogenesis.\u003c\/p\u003e","products":[{"product_id":"rb1-human","title":"RB1 Human","description":"\u003cp\u003eRetinoblastoma Associated Protein Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eRB, OSRC, RB-1, RB1, p105-Rb, OSTEOSARCOMA, RETINOBLASTOMA-RELATED,PP110, Retinoblastoma-associated protein.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43175237189716,"sku":"PRO-584","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43175237222484,"sku":"PRO-584","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175237255252,"sku":"PRO-584","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-rb1-human-PRO-584.png?v=1776709215"},{"product_id":"rbbp4-human","title":"RBBP4 Human","description":"\u003cp\u003eRetinoblastoma Binding Protein 4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eHistone-binding protein RBBP4, Chromatin assembly factor 1 subunit C, CAF-1 subunit C, Chromatin assembly factor I p48 subunit, CAF-I 48 kDa subunit, CAF-I p48, Nucleosome-remodeling factor subunit RBAP48, Retinoblastoma-binding protein 4, RBBP-4, Retinoblastoma-binding protein p48, RBBP4, RBAP48, NURF55.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175238303828,"sku":"PRO-1168","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175238336596,"sku":"PRO-1168","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175238369364,"sku":"PRO-1168","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-rbbp4-human-PRO-1168.png?v=1776709220"},{"product_id":"rbbp9-human","title":"RBBP9 Human","description":"\u003cp\u003eRetinoblastoma Binding Protein 9 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eRetinoblastoma binding protein 9, RBBP-9, Retinoblastoma-binding protein 10, RBBP-10, BOG, B5T-overexpressed gene protein, putative hydrolase RBBP9, retinoma-binding protein 9.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175239352404,"sku":"PRO-991","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175239385172,"sku":"PRO-991","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175239417940,"sku":"PRO-991","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-rbbp9-human-PRO-991.png?v=1776709224"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_89e13e04-b236-4d7f-b8ad-049d2362789d.png?v=1700647829","url":"https:\/\/prospecbio.com\/collections\/retinoblastoma.oembed","provider":"prospecbio","version":"1.0","type":"link"}