{"title":"Reticulocalbin","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout RCN \/ Reticulocalbin:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eReticulocalbin refers to a family of proteins that are important to the immune system. They help trigger a response from white blood cells and serve as an initial point for other responses.\u003cbr data-mce-fragment=\"1\"\u003eRCN is not only involved in immunity. It also plays a role in inflammation as well as neuron growth.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eRCN Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eReticulocalbin is one of the many small proteins that are found in all living organisms. It has many functions, including transporting nutrients to cells and food particles from inside a cell out into the gut. It also takes waste material from the gut back up through your body and removes it when you defecate or urinate.\u003cbr data-mce-fragment=\"1\"\u003eIn addition, Reticulocalbin is essential for eliminating cholesterol by breaking down bile acids in humans. Without enough RCN in our bodies, we would not break down fats efficiently, leading to health problems such as gallstones or liver disease.\u003cbr data-mce-fragment=\"1\"\u003eReticulocalbin's mechanism can differ depending on what type of food it is interacting with. When bacteria are present, reticulocalbin will bind to them and pull the waste material away from other cells in your body for disposal elsewhere.\u003cbr data-mce-fragment=\"1\"\u003eIn contrast, when there are no bacteria around, a different mechanism called endocytosis occurs where food particles taken up by cells on one side of the membrane use RCN as an anchor to bring them back across into another cell or part of the organism's surface area. These two mechanisms mean that without enough RCN, our bodies would not remove fat efficiently, which could cause problems such as gallstones or liver disease.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eReticulocalbin Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eReticulocalbin contains two domains. One that is involved in nucleotide binding and the other that binds to phospholipids. It also has an N-terminal domain for targeting, a C-terminal domain for substrate recognition, and an SBD or secondary binding site which recognizes cholesterol esters. Reticulocalbin interacts with different membrane lipids by recognizing headgroups like acyl chains of sphingomyelin through its second interaction sites. The interactions affect both structure and conformation due to conformational changes as well as lipid translocation into preformed multivesicular bodies or MVBs.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eRCN Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThere are a few different interactions that reticulocalbin can have with other proteins. For example, it has been shown to bind and inhibit the interaction of protein phosphatase-phosphodiesterases (PDE) with both cyclin D and CDKs in vitro but not in vivo. PDE is rapidly endocytosed during cell cycle progression after being released from its inhibitor binding site on RCN.\u003cbr data-mce-fragment=\"1\"\u003eIt also increased levels of PDE expression through an unknown mechanism without any effect on p38 or ERK activation suggesting there may be another unidentified regulator controlling this process. Reticulocalbin was also found to interact directly with Hsp27 at lysine residues 114\/115, resulting in increased Hsp27 protein stability.\u003cbr data-mce-fragment=\"1\"\u003eReticulocalbin can bind and inhibit the interaction of PDE with cyclin D and CDKs as well as increase Hsp27 expression through direct binding to it at lysine residues 114\/115.\u003c\/p\u003e","products":[{"product_id":"rcn1-human","title":"RCN1 Human","description":"\u003cp\u003eReticulocalbin 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003ePIG20, RCAL, RCN.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175260979284,"sku":"PRO-544","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175261012052,"sku":"PRO-544","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175261044820,"sku":"PRO-544","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-rcn1-human-PRO-544.png?v=1776709312"},{"product_id":"rcn2-human","title":"RCN2 Human","description":"\u003cp\u003eReticulocalbin 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eReticulocalbin-2, Calcium-binding protein ERC-55, E6-binding protein, 6BP, RCN2, ERC55, E6BP, ERC-55, TCBP49.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175261831252,"sku":"PRO-189","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175261864020,"sku":"PRO-189","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175261896788,"sku":"PRO-189","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-rcn2-human-PRO-189.png?v=1776709316"},{"product_id":"rcn3-human","title":"RCN3 Human","description":"\u003cp\u003eReticulocalbin 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eReticulocalbin-3, EF-hand calcium-binding protein RLP49, RCN3, RLP49.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175262748756,"sku":"PRO-1049","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175262781524,"sku":"PRO-1049","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175262814292,"sku":"PRO-1049","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-rcn3-human-PRO-1049.png?v=1776709320"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_90a0bc8c-5124-470f-ad57-c52ce24549e0.png?v=1700647835","url":"https:\/\/prospecbio.com\/collections\/reticulocalbin.oembed","provider":"prospecbio","version":"1.0","type":"link"}