{"title":"RAN Binding Protein","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout RANBP \/ RAN Binding Protein:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe RAN binding protein is an enzyme. It is present in humans, where it is encoded by the RANBP1 gene. The RANBP will interact exclusively with GTP-charged Ran. It encodes the 23-kD protein, which binds to RAn complexed -- not with GDP, but with GTP. It will not activate the GTPase activity of RAN. However, it will have a big impact on GTP hydrolysis by the RANGTPase-activating protein. Furthermore, the RANBP1 cDNA will encode a 201-amino acid protein if it is 92% similar to its mouse homolog. The RANBP1 will act as a negative regulator of RCC1 by inhibiting RCC!-stimulate guanine nucleotide release from RAN. It will bind to two different types of effector that you’ll find within the cell. The RAN-binding proteins play a role in ending export processes from the nucleus to the cytoplasm. Researchers have also found that they have importin-beta-like molecules -- these help to bind cargo proteins during nuclear transport.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eRANBP Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eYou’ll find the ran-binding domain, which is a conserved sequence motif, in several proteins that are involved in the transport processes. RanBP2 contains four domains, which means it is responsible for a significant portion of the cytoplasmic fibrils, which come from the nuclear-pore complex. In terms of structure, the ran bound to a non-hydrolysable GTP analogue in complex with the first ran-binding domain -- in the human RanBP2 -- shows that the RanBD1 has a pleckstrin-homology domain fold. It has also been shown that the switch-I region of Ran x GppNHp is similar to the canonical Ras GppNHp structure.\u003c\/p\u003e","products":[{"product_id":"ranbp1-human","title":"RANBP1 Human","description":"\u003cp\u003eRAN Binding Protein 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eRAN binding protein 1, HTF9A, ran-specific GTPase-activating protein, RanBP1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175199539284,"sku":"PRO-1064","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43175199572052,"sku":"PRO-1064","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175199604820,"sku":"PRO-1064","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-ranbp1-human-PRO-1064.png?v=1776709061"},{"product_id":"ranbp3-human","title":"RANBP3 Human","description":"\u003cp\u003eRAN Binding Protein 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eRAN binding protein 3, RanBP3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175202095188,"sku":"PRO-1986","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175202127956,"sku":"PRO-1986","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175202160724,"sku":"PRO-1986","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-ranbp3-human-PRO-1986.png?v=1776709073"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_fb7fee23-6011-4d7d-b2a0-ec17e0d805b4.png?v=1700647821","url":"https:\/\/prospecbio.com\/collections\/ran-binding-protein.oembed","provider":"prospecbio","version":"1.0","type":"link"}