{"title":"Proteasome","description":"\u003ch3 class=\"highlited\"\u003e\u003cspan\u003eAbout Proteasome:\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003eResponsible for the degradation of damaged proteins, Proteasomes complete the process of proteolysis. This chemical reaction breaks down peptide bonds. The enzymes that are responsible for this type of reaction are commonly referred to as proteases.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProteasome Mechanism and Function\u003c\/strong\u003e\u003cbr\u003eThe proteasomes are a part of the mechanism by which cells regulate the particular levels of proteins and continue to degrade proteins that have been misfolded. The cells that need to be degraded are typically tagged with a much smaller protein which will typically be known as ubiquitin. The reaction that occurs here is known as ubiquitin ligases.\u003cbr\u003eAfter a protein has been tagged with a particular ubiquitin molecule, a signal is created. It causes various other ligases to attach to additional ubiquitin molecules as well. The result of this creates the polyubiquitin chain. This is bound by the proteasome which is then encouraged to further degrade and eliminate the protein that has been tagged.\u003cbr\u003eThe mechanism here will cause peptides to be yielded and these are between seven or eight amino acids in length. These can lead to the synthesizing of brand new proteins as well. These will typically be created in the cytoplasm.\u003cbr\u003eThese processes will typically occur through cellular stress. Potential causes include heat shock, infection and oxidative damage to name just a few possibilities. During this time certain proteins are targeted for degradation and this is expressed through effective tagging. Various proteins have also been seen to cause an increase in activity through the ubiquitin-proteasome system. It is important to realize that these proteins including Hsps27 are not actually direct participants in the process though they certainly seem to play a role.\u003cbr\u003eThere are also mechanisms that exist which are used to further promote the degradation of cells that have been damaged through oxidation. This occurs through the proteasome system as well.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProteasome Interaction\u003c\/strong\u003e\u003cbr\u003eIt’s true to say that proteasome is responsible for a wide range of different interactions in the body and specific cellular processes This includes the regulations of the gene expression, the cell cycle and the response to any oxidative stress.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProteasome Structure\u003c\/strong\u003e\u003cbr\u003eThe proteasome has a cylindrical structure. This contains a unique core of four rings that are stacked together. This forms the central core. These are formed of several individual proteins. They are also made of seven different subunits that contain three to seven different proteins that are entirely individual. There are also various active sites which are located on the interior surface of the different rings.\u003cbr\u003eThis means that the target protein must enter the central pore before it is effectively degraded through the process. At the same time, the two outer rings will contain seven different subunits. The function of these is to effectively maintain the gate by which protein enters through.\u003cbr\u003eThese subunits function through the control of being bound to a ‘cap’ structure. These are also known as regulatory particles which are a key part of the degradation process.\u003c\/p\u003e","products":[{"product_id":"psma1-human","title":"PSMA1 Human","description":"\u003cp\u003eProteasome Subunit Alpha Type 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProteasome (prosome macropain) subunit alpha type 1, PROS30, HC2, NU, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome component C2, Proteasome nu chain, 30 kDa prosomal protein, protein P30-33K, PROS-30, PSC2, EC 3.4.25.1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175018102868,"sku":"ENZ-178","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175018135636,"sku":"ENZ-178","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175018168404,"sku":"ENZ-178","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psma1-human-ENZ-178.png?v=1776708141"},{"product_id":"psma2-human","title":"PSMA2 Human","description":"\u003cp\u003eProteasome Subunit Alpha Type 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProteasome subunit alpha type-2, Macropain subunit C3, Multicatalytic endopeptidase complex subunit C3, Proteasome component C3, PSMA2, HC3, PSC3, MU, PSC2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175019184212,"sku":"ENZ-175","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175019216980,"sku":"ENZ-175","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175019249748,"sku":"ENZ-175","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psma2-human-ENZ-175.png?v=1776708145"},{"product_id":"psma3-human","title":"PSMA3 Human","description":"\u003cp\u003eProteasome Subunit Alpha Type 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eproteasome (prosome, macropain) subunit alpha type-3, HC8, Macropain subunit C8, Multicatalytic endopeptidase complex subunit C8, Proteasome component C8, PSC3, PSC8, EC 3.4.25.1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175020462164,"sku":"ENZ-196","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175020494932,"sku":"ENZ-196","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175020527700,"sku":"ENZ-196","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psma3-human-ENZ-196.png?v=1776708149"},{"product_id":"psma4-human","title":"PSMA4 Human","description":"\u003cp\u003eProteasome Subunit Alpha Type 4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProteasome subunit alpha type-4, Macropain subunit C9, Multicatalytic endopeptidase complex subunit C9, Proteasome component C9, Proteasome subunit L, PSMA4, HC9, PSC9, HsT17706.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175021379668,"sku":"ENZ-222","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175021412436,"sku":"ENZ-222","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175021445204,"sku":"ENZ-222","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psma4-human-ENZ-222.png?v=1776708153"},{"product_id":"psma5-human","title":"PSMA5 Human","description":"\u003cp\u003eProteasome Subunit Alpha Type 5 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProteasome subunit alpha type-5, Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain, PSMA5, PSC5, ZETA.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43175022493780,"sku":"ENZ-213","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43175022526548,"sku":"ENZ-213","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43175022559316,"sku":"ENZ-213","price":1100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psma5-human-ENZ-213.png?v=1776708158"},{"product_id":"psma6-human","title":"PSMA6 Human","description":"\u003cp\u003eProteasome Subunit Alpha Type 6 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProteasome (prosome, macropain) subunit alpha type 6, PROS27, p27K, IOTA, Macropain iota chain, Multicatalytic endopeptidase complex iota chain, Proteasome iota chain, 27 kDa prosomal protein.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175023607892,"sku":"ENZ-198","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175023640660,"sku":"ENZ-198","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175023673428,"sku":"ENZ-198","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psma6-human-ENZ-198.png?v=1776708163"},{"product_id":"psma7-human","title":"PSMA7 Human","description":"\u003cp\u003eProteasome Subunit Alpha Type 7 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eHSPC, RC6-1, XAPC7, MGC3755, PSMA-7, Proteasome subunit alpha type-7, Proteasome subunit RC6-1, Proteasome subunit XAPC7, PSMA7, C6.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43175024689236,"sku":"ENZ-403","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43175024722004,"sku":"ENZ-403","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175024754772,"sku":"ENZ-403","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psma7-human-ENZ-403.png?v=1776708167"},{"product_id":"psma8-human","title":"PSMA8 Human","description":"\u003cp\u003eProteasome Subunit Alpha Type 8 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProteasome subunit alpha type-7-like, PSMA8, PSMA7L.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175026393172,"sku":"ENZ-203","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175026425940,"sku":"ENZ-203","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175026458708,"sku":"ENZ-203","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psma8-human-ENZ-203.png?v=1776708172"},{"product_id":"psmb1-human","title":"PSMB1 Human","description":"\u003cp\u003eProteasome Subunit Beta Type 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eHC5, PSC5, PMSB1, FLJ25321, KIAA1838, PSMB1, Proteasome subunit beta type-1, Proteasome component C5, Macropain subunit C5, Multicatalytic endopeptidase complex subunit C5, Proteasome gamma chain.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175027343444,"sku":"ENZ-405","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175027376212,"sku":"ENZ-405","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175027408980,"sku":"ENZ-405","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psmb1-human-ENZ-405.png?v=1776708177"},{"product_id":"psmb10-human","title":"PSMB10 Human","description":"\u003cp\u003eProteasome Beta Type 10 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProteasome subunit beta type-10, Low molecular mass protein 10, Macropain subunit MECl-1, Multicatalytic endopeptidase complex subunit MECl-1, Proteasome MECl-1, Proteasome subunit beta-2i, PSMB10, LMP10, MECL1, beta2i, MGC1665, FLJ00366.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43175028392020,"sku":"PRO-931","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43175028424788,"sku":"PRO-931","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43175028457556,"sku":"PRO-931","price":1100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psmb10-human-PRO-931.png?v=1776708183"},{"product_id":"psmb2-human","title":"PSMB2 Human","description":"\u003cp\u003eProteasome Subunit Beta Type 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProteasome subunit beta type-2, Macropain subunit C7-I, Multicatalytic endopeptidase complex subunit C7-I, Proteasome component C7-I, PSMB2, HC7-I.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175029309524,"sku":"ENZ-204","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175029342292,"sku":"ENZ-204","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175029375060,"sku":"ENZ-204","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psmb2-human-ENZ-204.png?v=1776708188"},{"product_id":"psmb3-human","title":"PSMB3 Human","description":"\u003cp\u003eProteasome Subunit Beta Type 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProteasome (prosome, macropain) subunit beta type 3, Proteasome chain 13, HC10-II, Proteasome component C10-II, Proteasome theta chain, EC 3.4.25.1, MGC4147.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175030358100,"sku":"ENZ-200","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175030390868,"sku":"ENZ-200","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175030423636,"sku":"ENZ-200","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psmb3-human-ENZ-200.png?v=1776708192"},{"product_id":"psmb4-human","title":"PSMB4 Human","description":"\u003cp\u003eProteasome Subunit Beta Type 4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProteasome (prosome, macropain) subunit beta type 4, PROS26, HN3, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome chain 3, 26 kDa prosomal protein, HsN3, PROS-26, hsBPROS26, EC 3.4.25.1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175031111764,"sku":"ENZ-197","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175031144532,"sku":"ENZ-197","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175031177300,"sku":"ENZ-197","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psmb4-human-ENZ-197.png?v=1776708197"},{"product_id":"psmb5-human","title":"PSMB5 Human","description":"\u003cp\u003eProteasome Subunit Beta Type 5 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProteasome subunit beta type-5, Macropain epsilon chain, Multicatalytic endopeptidase complex epsilon chain, Proteasome chain 6, Proteasome epsilon chain, Proteasome subunit MB1, Proteasome subunit X, PSMB5, LMPX, MB1, X, MGC104214.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175032062036,"sku":"ENZ-050","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175032094804,"sku":"ENZ-050","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175032127572,"sku":"ENZ-050","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psmb5-human-ENZ-050.png?v=1776708202"},{"product_id":"psmb6-human","title":"PSMB6 Human","description":"\u003cp\u003eProteasome Subunit Beta Type 6 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProteasome subunit beta type-6, Macropain delta chain, Multicatalytic endopeptidase complex delta chain, Proteasome delta chain, Proteasome subunit Y, PSMB6, LMPY, Y, DELTA.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175033241684,"sku":"ENZ-223","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175033274452,"sku":"ENZ-223","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175033307220,"sku":"ENZ-223","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psmb6-human-ENZ-223.png?v=1776708208"},{"product_id":"psmb7-human","title":"PSMB7 Human","description":"\u003cp\u003eProteasome Subunit Beta Type 7 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProteasome subunit beta type-7, Macropain chain Z, Multicatalytic endopeptidase complex chain Z, Proteasome subunit Z, PSMB7, Z.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43175034617940,"sku":"ENZ-577","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43175034650708,"sku":"ENZ-577","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43175034683476,"sku":"ENZ-577","price":1100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psmb7-human-ENZ-577.png?v=1776708212"},{"product_id":"psmb8-human","title":"PSMB8 Human","description":"\u003cp\u003eProteasome Subunit Beta Type 8 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eD6S216, D6S216E, LMP7, MGC1491, PSMB5i , Low molecular mass protein 7 Macropain subunit C13, Multicatalytic endopeptidase complex subunit C13,Proteasome component C13, Proteasome subunit beta-5i, Really interesting new gene 10 protein.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175035699284,"sku":"ENZ-670","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175035732052,"sku":"ENZ-670","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175035764820,"sku":"ENZ-670","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psmb8-human-ENZ-670.png?v=1776708217"},{"product_id":"psmb9-human","title":"PSMB9 Human","description":"\u003cp\u003eProteasome Subunit Beta Type 9 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProteasome subunit beta type-9, Low molecular mass protein 2, Macropain chain 7, Multicatalytic endopeptidase complex chain 7, Proteasome chain 7, Proteasome subunit beta-1i, Really interesting new gene 12 protein, PSMB9, LMP2, PSMB6i, RING12, beta1i, MGC70470.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175036878932,"sku":"ENZ-105","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175036911700,"sku":"ENZ-105","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175036944468,"sku":"ENZ-105","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-psmb9-human-ENZ-105.png?v=1776708223"},{"product_id":"psmd10-human","title":"PSMD10 Human","description":"\u003cp\u003eGankyrin Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003e26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit p28, Gankyrin, PSMD10, p28, 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