{"title":"Prohibitin","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout PHB \/ Prohibitin:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThere are two forms of prohibitin: prohibitin 1 (PHB1) and prohibitin 2 (PHB2). These proteins are ubiquitously expressed and can be found in the nucleus, cytosol and mitochondria of a cell. Of course, these proteins have significant functions (differing depending on their cellular localization) and research suggests that they play a vital role within the mitochondria. This reflects in the fact that you will find that PHB proteins are highly expressed in cells that heavily depend on mitochondrial function.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003ePHB Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eWithin mitochondria, these two proteins will assemble at the inner membrane to form a supra-macromolecular structure. This will then work as a scaffold for proteins and lipids regulating mitochondrial metabolism This scaffold can then play a role in bioenergetics, biogenesis and dynamics, going on to determine the cell fate, death or life.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eProhibitin Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003ePHB has been found when researching conditions such as aging, cancer, neurodegenerative diseases, cardiac diseases, kidney diseases and other diseases in which significant mitochondrial impairments have been observed.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003ePHB Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003ePHB1 has a molecular weight of 23kDa and PHB2 has a molecular weight 34 kDa. Both proteins are composed of an N-terminal transmembrane domain that is an evolutionarily conserved prohibitin domain. This domain is common to other scaffold proteins (including stomatin, stomatin-like proteins 1, 2, 3, flotillin, and HflK\/C) and a C-terminal coiled-coil domain. This domain is involved in protein–protein interactions, including the interaction between themselves and with transcriptional regulators.\u003cbr data-mce-fragment=\"1\"\u003eIn terms of structure, PHB1 and 2 form a ring-like structure of approximately 1 MDa. This consists of about 12–20 PHB heterodimers, at the mitochondrial inner membrane.\u003c\/p\u003e","products":[{"product_id":"phb-human","title":"PHB Human","description":"\u003cp\u003eProhibitin Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003ePHB1, Prohibitin.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174669713492,"sku":"PRO-1381","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174669746260,"sku":"PRO-1381","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174669779028,"sku":"PRO-1381","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-phb-human-PRO-1381.png?v=1776705820"},{"product_id":"phb2-human","title":"PHB2 Human","description":"\u003cp\u003eProhibitin 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eBAP, Bap37, BCAP37, p22, PNAS-141, REA, Prohibitin-2, B-cell receptor-associated protein BAP37, D-prohibitin, Repressor of estrogen receptor activity, PHB2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174670794836,"sku":"PRO-1533","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174670827604,"sku":"PRO-1533","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174670860372,"sku":"PRO-1533","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-phb2-human-PRO-1533.png?v=1776705828"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_3907ba6f-0a49-4088-895e-cb231730569d.png?v=1700647768","url":"https:\/\/prospecbio.com\/collections\/prohibitin.oembed","provider":"prospecbio","version":"1.0","type":"link"}