{"title":"Polymerase (RNA) (DNA directed) Polypeptide","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout POL \/ Polymerase (RNA) (DNA directed) Polypeptide:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eRNA polymerase (abbreviated RNAP or RNApol, and officially DNA-directed (dependent) RNA polymerase) is a molecular biology enzyme synthesizing RNA from a DNA template.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003ePOL Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eRNAP locally opens the double-stranded DNA using the enzyme helicase. One strand of the exposed nucleotides can be utilized as a template for RNA production, a process known as transcription. Before RNAP can begin unwinding the DNA at that place, a transcription factor and its accompanying transcription mediator complex must be linked to a DNA binding site known as a promoter region. RNAP not only begins RNA transcription, but it also guides nucleotides into position, aids attachment and elongation, has inherent proofreading and replacement capabilities, and termination recognition capability. RNAP can form chains as long as 2.4 million nucleotides in eukaryotes.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003ePolymerase (RNA) (DNA directed) Polypeptide Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eA single RNA polymerase species transcribes all kinds of RNA in most prokaryotes. The \"core\" of E. coli RNA polymerase is made up of five subunits: two alpha () subunits of 36 kDa, a beta () subunit of 150 kDa, a beta prime subunit (′) of 155 kDa, and a tiny omega () subunit. A sigma () factor attaches to the core, resulting in the formation of the holoenzyme. After transcription begins, the factor might unbind and let the core enzyme continue its activity. The core RNA polymerase complex takes the shape of a \"crab claw\" or \"clamp-jaw\" structure, with an internal channel running the length of it. Although they have many more subunits, eukaryotic and archaeal RNA polymerases have a similar fundamental structure and function.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003ePOL Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eControl of the gene transcription process affects gene expression patterns, allowing a cell to adapt to a changing environment, perform specialized roles within an organism, and sustain essential metabolic processes required for survival. As a result, it is not surprising that RNAP activity is protracted, complex, and highly regulated. More than 100 transcription factors have been found in Escherichia coli bacteria that affect the activity of RNAP.\u003c\/p\u003e","products":[{"product_id":"pole3-human","title":"POLE3 Human","description":"\u003cp\u003ePolymerase (DNA Directed), Epsilon 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCHARAC17, CHRAC17, p17, YBL1,DNA polymerase epsilon subunit 3, Arsenic-transactivated protein,AsTP, Chromatin accessibility complex 17 kDa protein, HuCHRAC17, DNA polymerase II subunit 3, DNA polymerase epsilon subunit p17, POLE3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174804258900,"sku":"PRO-1496","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174804291668,"sku":"PRO-1496","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174804324436,"sku":"PRO-1496","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-pole3-human-PRO-1496.png?v=1776706811"},{"product_id":"polr1c-human","title":"POLR1C Human","description":"\u003cp\u003ePolymerase (RNA) I (DNA directed) Polypeptide C Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eDNA-directed RNA polymerases I and III subunit RPAC1, POLR1C, POLR1E, RPC40, Polymerase (RNA) I (DNA directed) Polypeptide C, RPA40, RPA39, DNA-directed RNA polymerases I and III 40 kDa polypeptide, RNA polymerases I and III subunit AC1, AC40, DNA-directed RNA polymerase I subunit C, RP3-337H4.4, RPA5, RPAC1, TCS3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174806323284,"sku":"PRO-2018","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174806356052,"sku":"PRO-2018","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174806388820,"sku":"PRO-2018","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-polr1c-human-PRO-2018.png?v=1776706830"},{"product_id":"polr2c-human","title":"POLR2C Human","description":"\u003cp\u003ePolymerase (RNA) II (DNA directed) Polypeptide C Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003ehRPB33, hsRPB3, RPB3, RPB31, DNA-directed RNA polymerase II subunit RPB3, RNA polymerase II subunit 3, RNA polymerase II subunit B3, DNA-directed RNA polymerase II 33 kDa polypeptide, RPB33, DNA-directed RNA polymerase II subunit C, POLR2C.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174807404628,"sku":"PRO-1994","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174807437396,"sku":"PRO-1994","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174807470164,"sku":"PRO-1994","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-polr2c-human-PRO-1994.png?v=1776706839"},{"product_id":"polr2h-human","title":"POLR2H Human","description":"\u003cp\u003ePolymerase (RNA) II (DNA directed) Polypeptide H Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eDNA-directed RNA polymerases I, II, and III subunit RPABC3, RNA polymerases I, II, and III subunit ABC3, DNA-directed RNA polymerase II subunit H, DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide, RPB17, RPB8 homolog, hRPB8, POLR2H, polymerase (RNA) II (DNA directed) polypeptide H, RPB8, RPABC3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174811795540,"sku":"PRO-1443","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174811828308,"sku":"PRO-1443","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174811861076,"sku":"PRO-1443","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-polr2h-human-PRO-1443.png?v=1776706870"},{"product_id":"polr2j-human","title":"POLR2J Human","description":"\u003cp\u003ePolymerase (RNA) II (DNA directed) Polypeptide J Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eDNA-directed RNA polymerase II subunit RPB11-a, RNA polymerase II subunit B11-a, RPB11a, DNA-directed RNA polymerase II subunit J-1, RNA polymerase II 13.3 kDa subunit, POLR2J, POLR2J1, RPB11, RPB11m, hRPB14.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174813827156,"sku":"PRO-1260","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174813859924,"sku":"PRO-1260","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174813892692,"sku":"PRO-1260","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-polr2j-human-PRO-1260.png?v=1776706889"},{"product_id":"polr2k-human","title":"POLR2K Human","description":"\u003cp\u003ePolymerase (RNA) II (DNA directed) Polypeptide K Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003ePolymerase (RNA) II (DNA Directed) Polypeptide K, 7.0kDa, RNA Polymerases I, II, And III Subunit ABC4, DNA-Directed RNA Polymerase II Subunit K, RNA Polymerase II 7.0 KDa Subunit, ABC10-Alpha, RPB10alpha, RPB7.0, RPB12,DNA Directed RNA Polymerases I, II, And III 7.0 Kda Polypeptide, DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4, Polymerase (RNA) II (DNA Directed) Polypeptide K (7.0kD), HsRPB10a, HRPB7.0, RPABC4, POLR2K.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174817202260,"sku":"PRO-2131","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174817235028,"sku":"PRO-2131","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174817267796,"sku":"PRO-2131","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-polr2k-human-PRO-2131.png?v=1776706912"},{"product_id":"polr3h-human","title":"POLR3H Human","description":"\u003cp\u003ePolymerase (RNA) III (DNA directed) Polypeptide H Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eDNA-directed RNA polymerase III subunit RPC8, RNA polymerase III subunit C8, DNA-directed RNA polymerase III subunit H, RNA polymerase III subunit 22.9 kDa subunit, RPC22.9, POLR3H, KIAA1665, RPC8.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174819430484,"sku":"PRO-1250","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174819463252,"sku":"PRO-1250","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174819496020,"sku":"PRO-1250","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-polr3h-human-PRO-1250.png?v=1776706931"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_09f3d511-8c0b-430b-ae4b-64e4f809c975.png?v=1700647783","url":"https:\/\/prospecbio.com\/collections\/polymerase-rna-dna-directed-polypeptide.oembed","provider":"prospecbio","version":"1.0","type":"link"}