{"title":"PCNA","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout PCNA \/ Proliferating Cell Nuclear Antigen Protein:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eCell nuclear antigen protein PCNA is a DNA polymerase that helps initiate the synthesis of DNA. It also assists in both DNA repair and replication processes.\u003cbr data-mce-fragment=\"1\"\u003ePCNA is a nucleotide-binding protein with three domains:\u003cbr data-mce-fragment=\"1\"\u003e●An N-terminal region for ATP binding\u003cbr data-mce-fragment=\"1\"\u003e●A middle part responsible for catalysis\u003cbr data-mce-fragment=\"1\"\u003e●The C-terminus which binds to DNA\u003cbr data-mce-fragment=\"1\"\u003eThis enzyme can be in various locations throughout the cell, such as chromatin during mitosis or after UV irradiation.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMechanism of PCNA\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003ePCNA binds to the single-stranded DNA on one side and, with ATP present, it helps direct the second strand of DNA. PCNA also facilitates the removal of RNA primers in replication and is involved in maintaining fidelity during replication.\u003cbr data-mce-fragment=\"1\"\u003eThis protein is essential for genome stability and sensitivity to UV irradiation as well as for DNA repair.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eFunctions of Proliferating Cell Nuclear Antigen Protein\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003ePCNA has an extensive range of functions in the cell and is involved with processes such as replication, transcription, recombination, and meiosis.\u003cbr data-mce-fragment=\"1\"\u003eIt helps maintain genome stability by repairing single-stranded breaks that can lead to mutations or rearrangements. Cells need an increased PCNA level when exposed to UV-light or cisplatin.\u003cbr data-mce-fragment=\"1\"\u003ePCNA is a vital component of the DNA replication process; it interacts with the primase complex to form an elongating RNA primer and helps maintain fidelity during replication by removing RNA primers from newly synthesized strands of DNA before they copy.\u003cbr data-mce-fragment=\"1\"\u003eIt also assists in recombination reactions that produce genetic diversity, and it is involved in meiosis and mitosis.\u003cbr data-mce-fragment=\"1\"\u003eIn conclusion, PCNA is a protein that helps initiate the synthesis of DNA. It assists in both DNA repair and replication processes, as well as maintaining genome stability.\u003c\/p\u003e","products":[{"product_id":"pcna-human","title":"PCNA Human","description":"\u003cp\u003eProliferating Cell Nuclear Antigen Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProliferating cell nuclear antigen, PCNA, Cyclin, MGC8367.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174517538900,"sku":"PRO-615","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174517571668,"sku":"PRO-615","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174517604436,"sku":"PRO-615","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-pcna-human-PRO-615.png?v=1776704939"},{"product_id":"pcna-human-sf9","title":"PCNA Human, Sf9","description":"\u003cp\u003eProliferating Cell Antigen Human Recombinant, Sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eProliferating cell nuclear antigen, PCNA, Cyclin, MGC8367.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174519799892,"sku":"PRO-303","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174519832660,"sku":"PRO-303","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174519865428,"sku":"PRO-303","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-pcna-human-sf9-PRO-303.png?v=1776704945"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_6bed7ee6-2c89-494e-a060-b08e0eec0e5c.png?v=1700647748","url":"https:\/\/prospecbio.com\/collections\/pcna.oembed","provider":"prospecbio","version":"1.0","type":"link"}